| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,511,000 | 10,607,924 | +8,096,924 | 0.03 | 0.14 | +0.11 | buy |
| TCG Crossover Management, LLC | 8,536,196 | 12,762,094 | +4,225,898 | 3.53 | 3.74 | +0.21 | buy |
| Logos Global Management LP | 950,000 | 4,200,000 | +3,250,000 | 0.79 | 2.48 | +1.69 | buy |
| Siren, L.L.C. | 5,883,188 | 8,165,374 | +2,282,186 | 1.93 | 2.16 | +0.22 | buy |
| Nantahala Capital Management, LLC | 1,809,948 | 3,572,633 | +1,762,685 | 0.53 | 1.05 | +0.52 | buy |
| Nextech Invest, Ltd. | 5,533,980 | 7,266,081 | +1,732,101 | 7.08 | 6.22 | -0.85 | buy |
| Vivo Capital, LLC | 776,699 | 2,154,780 | +1,378,081 | 0.53 | 1.23 | +0.71 | buy |
| Boxer Capital Management, LLC | 9,771,485 | 10,876,219 | +1,104,734 | 26.16 | 21.09 | -5.07 | buy |
| Deep Track Capital, LP | 1,454,562 | 2,454,562 | +1,000,000 | 0.34 | 0.50 | +0.16 | buy |
| Rafferty Asset Management, LLC | 145,316 | 226,601 | +81,285 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,288 | 83,759 | +52,471 | 0.01 | 0.02 | 0.00 | buy |
| AXQ CAPITAL, LP | 13,468 | 20,268 | +6,800 | 0.04 | 0.04 | -0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 228,120 | 234,628 | +6,508 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 22,532 | 28,452 | +5,920 | 0.05 | 0.07 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 19,502 | 21,946 | +2,444 | 0.01 | 0.01 | +0.00 | buy |
| TFC Financial Management, Inc. | 800 | 1,300 | +500 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,394 | 2,646 | +252 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 423,851 | 294,303 | -129,548 | 0.03 | 0.02 | -0.01 | sell |
| Soleus Capital Management, L.P. | 300,000 | 10,000 | -290,000 | 0.13 | 0.00 | -0.13 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 653,493 | -2,058,515 | 1.51 | 0.44 | -1.07 | sell |
| T. Rowe Price Investment Management, Inc. | 3,526,359 | 446,213 | -3,080,146 | 0.02 | 0.00 | -0.02 | sell |
| TRV GP IV, LLC | 13,863,975 | 7,874,574 | -5,989,401 | 42.51 | 27.35 | -15.16 | sell |