| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 10,757,000 | 13,061,411 | +2,304,411 | 0.51 | 0.60 | +0.09 | buy |
| TCG Crossover Management, LLC | 8,536,196 | 12,762,094 | +4,225,898 | 3.53 | 3.74 | +0.21 | buy |
| Boxer Capital Management, LLC | 9,771,485 | 10,876,219 | +1,104,734 | 26.16 | 21.09 | -5.07 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,511,000 | 10,607,924 | +8,096,924 | 0.03 | 0.14 | +0.11 | buy |
| Woodline Partners LP | 6,029,928 | 10,072,225 | +4,042,297 | 0.24 | 0.35 | +0.11 | buy |
| BlackRock, Inc. | 5,646,919 | 8,540,797 | +2,893,878 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 5,883,188 | 8,165,374 | +2,282,186 | 1.93 | 2.16 | +0.22 | buy |
| TRV GP IV, LLC | 13,863,975 | 7,874,574 | -5,989,401 | 42.51 | 27.35 | -15.16 | sell |
| Nextech Invest, Ltd. | 5,533,980 | 7,266,081 | +1,732,101 | 7.08 | 6.22 | -0.85 | buy |
| VANGUARD GROUP INC | 5,052,003 | 6,750,977 | +1,698,974 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,365,205 | 6,218,567 | +2,853,362 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,472,207 | 5,278,580 | +1,806,373 | 0.06 | 0.09 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,509,475 | 4,942,414 | +3,432,939 | 0.00 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 950,000 | 4,200,000 | +3,250,000 | 0.79 | 2.48 | +1.69 | buy |
| Bellevue Group AG | 0 | 3,927,670 | +3,927,670 | 0.00 | 0.66 | +0.66 | buy |
| Caligan Partners LP | 0 | 3,729,895 | +3,729,895 | 0.00 | 3.03 | +3.03 | buy |
| Nantahala Capital Management, LLC | 1,809,948 | 3,572,633 | +1,762,685 | 0.94 | 1.89 | +0.95 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 2,906,946 | +2,906,946 | 0.00 | 0.33 | +0.33 | buy |
| FMR LLC | 6,426 | 2,867,548 | +2,861,122 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 2,662,227 | +2,662,227 | 0.00 | 0.59 | +0.59 | buy |
| JANUS HENDERSON GROUP PLC | 2,302,274 | 2,644,237 | +341,963 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,882,777 | 2,553,656 | +670,879 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 1,454,562 | 2,454,562 | +1,000,000 | 0.34 | 0.50 | +0.16 | buy |
| Vivo Capital, LLC | 776,699 | 2,154,780 | +1,378,081 | 0.53 | 1.23 | +0.71 | buy |
| Point72 Asset Management, L.P. | 2,919,450 | 1,974,035 | -945,415 | 0.05 | 0.03 | -0.03 | sell |
| RTW INVESTMENTS, LP | 0 | 1,491,228 | +1,491,228 | 0.00 | 0.13 | +0.13 | buy |
| MORGAN STANLEY | 251,793 | 1,421,794 | +1,170,001 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 926,904 | 1,398,057 | +471,153 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 430,379 | 1,025,553 | +595,174 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.64 | +0.64 | buy |
| UBS Group AG | 160,478 | 990,458 | +829,980 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 957,282 | +957,282 | 0.00 | 0.22 | +0.22 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 658,292 | 840,992 | +182,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 605,561 | 803,199 | +197,638 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 708,812 | 708,812 | 0 | 0.03 | 0.03 | +0.00 | hold |
| BESSEMER GROUP INC | 708,398 | 708,398 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 708,385 | 708,385 | 0 | 0.11 | 0.14 | +0.03 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,712,008 | 653,493 | -2,058,515 | 1.51 | 0.44 | -1.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,295,401 | 593,004 | -702,397 | 0.01 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 544,563 | +544,563 | 0.00 | 1.01 | +1.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 513,035 | +513,035 | 0.00 | 0.08 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 672,735 | 487,076 | -185,659 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 155,447 | 478,062 | +322,615 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,526,359 | 446,213 | -3,080,146 | 0.02 | 0.00 | -0.02 | sell |
| Rock Springs Capital Management LP | 0 | 386,915 | +386,915 | 0.00 | 0.18 | +0.18 | buy |
| BARCLAYS PLC | 365,680 | 368,187 | +2,507 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 192,348 | 343,840 | +151,492 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,489,518 | 329,231 | -1,160,287 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 0 | 318,676 | +318,676 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 928,012 | 300,441 | -627,571 | 0.00 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 423,851 | 294,303 | -129,548 | 0.03 | 0.02 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 282,732 | +282,732 | 0.00 | 1.70 | +1.70 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 384,207 | 255,127 | -129,080 | 0.01 | 0.01 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 228,120 | 234,628 | +6,508 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 253,288 | 233,857 | -19,431 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 145,316 | 226,601 | +81,285 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| TRV GP VI, LLC | 194,174 | 194,174 | 0 | 1.49 | 1.16 | -0.33 | hold |
| Fisher Asset Management, LLC | 210,352 | 187,693 | -22,659 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 1,031,917 | 177,610 | -854,307 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 173,936 | +173,936 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 151,880 | +151,880 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 144,432 | 144,432 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 0 | 140,021 | +140,021 | 0.00 | 0.09 | +0.09 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 129,476 | +129,476 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,839 | 129,107 | +21,268 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 24,752 | 121,781 | +97,029 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 55,005 | 121,186 | +66,181 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 118,593 | +118,593 | 0.00 | 0.09 | +0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 102,270 | 106,490 | +4,220 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 199,081 | 105,268 | -93,813 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 0 | 87,800 | +87,800 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,288 | 83,759 | +52,471 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 79,175 | 82,233 | +3,058 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 59,149 | 74,203 | +15,054 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 53,572 | 68,251 | +14,679 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 17,185 | 64,243 | +47,058 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,398 | 62,634 | +22,236 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 47,726 | 59,692 | +11,966 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 36,963 | 59,330 | +22,367 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 40,669 | 58,434 | +17,765 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 33,916 | 56,835 | +22,919 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 10,045 | 53,927 | +43,882 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 51,319 | +51,319 | 0.00 | 0.02 | +0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 50,400 | +50,400 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,788 | 48,210 | +43,422 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,465 | 47,811 | +34,346 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 35,244 | 41,907 | +6,663 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 41,453 | +41,453 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,445 | 39,430 | +32,985 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,152 | 38,941 | +10,789 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 37,838 | +37,838 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 18,102 | 36,236 | +18,134 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 36,000 | 36,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,839 | 35,216 | -53,623 | 0.00 | 0.00 | -0.00 | sell |
| Philadelphia Financial Management of San Francisco, LLC | 0 | 33,291 | +33,291 | 0.00 | 0.06 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 81,238 | 32,897 | -48,341 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,694 | 32,342 | +9,648 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 30,599 | +30,599 | 0.00 | 0.00 | +0.00 | buy |