| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 10,360,945 | 10,360,945 | 0 | 42.03 | 40.40 | -1.64 | hold |
| Patient Square Capital LP | 0 | 7,182,532 | +7,182,532 | 0.00 | 45.11 | +45.11 | buy |
| VANGUARD GROUP INC | 2,843,922 | 2,887,274 | +43,352 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 2,698,324 | 2,248,324 | -450,000 | 3.67 | 3.69 | +0.02 | sell |
| FINDELL CAPITAL MANAGEMENT LLC | 2,086,000 | 2,105,000 | +19,000 | 15.80 | 16.81 | +1.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 2,055,000 | +2,055,000 | 0.00 | 0.18 | +0.18 | buy |
| Vestal Point Capital, LP | 1,025,000 | 2,000,000 | +975,000 | 1.31 | 2.44 | +1.13 | buy |
| STATE STREET CORP | 959,167 | 1,226,178 | +267,011 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,042,909 | 1,130,232 | +87,323 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,006,357 | 685,439 | -320,918 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 558,658 | 558,658 | 0 | 0.23 | 0.23 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 268,888 | 486,788 | +217,900 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 40,024 | 459,402 | +419,378 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 416,697 | 446,084 | +29,387 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 422,499 | +422,499 | 0.00 | 0.02 | +0.02 | buy |
| Eversept Partners, LP | 688,926 | 396,187 | -292,739 | 0.81 | 0.44 | -0.38 | sell |
| Opaleye Management Inc. | 445,000 | 395,000 | -50,000 | 1.42 | 1.27 | -0.15 | sell |
| HARBERT FUND ADVISORS, INC. | 339,158 | 339,158 | 0 | 2.80 | 3.44 | +0.65 | hold |
| Whitefort Capital Management, LP | 231,558 | 337,607 | +106,049 | 1.78 | 3.03 | +1.26 | buy |
| JANE STREET GROUP, LLC | 30,916 | 306,942 | +276,026 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 351,315 | 292,855 | -58,460 | 0.01 | 0.01 | +0.00 | sell |
| LB Partners LLC | 282,947 | 282,947 | 0 | 3.73 | 4.29 | +0.56 | hold |
| TWO SIGMA ADVISERS, LP | 299,800 | 273,400 | -26,400 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 432,356 | 264,461 | -167,895 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 104,933 | 230,248 | +125,315 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 228,514 | +228,514 | 0.00 | 0.53 | +0.53 | buy |
| Cubist Systematic Strategies, LLC | 271,780 | 187,176 | -84,604 | 0.04 | 0.03 | -0.01 | sell |
| Walleye Capital LLC | 319,233 | 182,078 | -137,155 | 0.05 | 0.03 | -0.02 | sell |
| Bank of New York Mellon Corp | 172,402 | 175,885 | +3,483 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 161,617 | +161,617 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 481,395 | 161,421 | -319,974 | 0.01 | 0.00 | -0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 167,268 | 155,475 | -11,793 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 70,538 | 151,965 | +81,427 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.23 | +0.23 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 150,000 | +150,000 | 0.00 | 0.16 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 131,764 | 133,044 | +1,280 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 547,654 | 119,780 | -427,874 | 0.01 | 0.00 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 119,000 | +119,000 | 0.00 | 0.01 | +0.01 | buy |
| Sigma Planning Corp | 39,635 | 105,890 | +66,255 | 0.04 | 0.05 | +0.01 | buy |
| GTS SECURITIES LLC | 42,486 | 102,652 | +60,166 | 0.01 | 0.04 | +0.03 | buy |
| Walleye Trading LLC | 191,998 | 97,661 | -94,337 | 0.03 | 0.02 | -0.01 | sell |
| SkyView Investment Advisors, LLC | 111,571 | 93,253 | -18,318 | 0.34 | 0.25 | -0.08 | sell |
| Swiss National Bank | 0 | 89,800 | +89,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 103,021 | 89,124 | -13,897 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 56,240 | 82,317 | +26,077 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 6,903 | 77,703 | +70,800 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 75,978 | +75,978 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,331 | 71,293 | +962 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,955 | 68,554 | +63,599 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 179,173 | 68,204 | -110,969 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 222,211 | 67,912 | -154,299 | 1.63 | 0.56 | -1.07 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 66,600 | +66,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 62,002 | +62,002 | 0.00 | 0.00 | +0.00 | buy |
| Kepos Capital LP | 0 | 60,000 | +60,000 | 0.00 | 0.23 | +0.23 | buy |
| ALLIANCEBERNSTEIN L.P. | 56,760 | 56,760 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 21,071 | 53,634 | +32,563 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,915 | 53,468 | +8,553 | 0.00 | 0.01 | +0.00 | buy |
| Advisory Services Network, LLC | 43,535 | 52,935 | +9,400 | 0.01 | 0.02 | +0.00 | buy |
| Boston Partners | 0 | 51,642 | +51,642 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 160,641 | 48,905 | -111,736 | 0.06 | 0.02 | -0.04 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 48,317 | +48,317 | 0.00 | 0.41 | +0.41 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,812 | 46,181 | +38,369 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 17,174 | 36,462 | +19,288 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 36,010 | +36,010 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 34,659 | +34,659 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 34,122 | +34,122 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 33,250 | +33,250 | 0.00 | 0.01 | +0.01 | buy |
| Bleakley Financial Group, LLC | 31,193 | 33,250 | +2,057 | 0.01 | 0.01 | +0.00 | buy |
| Mariner, LLC | 10,454 | 30,516 | +20,062 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 29,692 | +29,692 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 27,540 | +27,540 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 27,223 | +27,223 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 31,148 | 26,040 | -5,108 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 25,586 | 25,586 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 23,591 | 24,806 | +1,215 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 75,081 | 24,732 | -50,349 | 0.08 | 0.02 | -0.05 | sell |
| CITIGROUP INC | 6,705 | 24,390 | +17,685 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 51,138 | 24,224 | -26,914 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 0 | 24,000 | +24,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 21,401 | 22,625 | +1,224 | 0.00 | 0.00 | +0.00 | buy |
| Catalina Capital Group, LLC | 10,615 | 21,416 | +10,801 | 0.10 | 0.14 | +0.04 | buy |
| Mirae Asset Global Investments Co., Ltd. | 19,771 | 19,771 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 31,402 | 19,591 | -11,811 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 18,820 | 19,422 | +602 | 0.03 | 0.05 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,312 | 19,277 | -35 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 18,429 | +18,429 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,832 | 18,134 | -698 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 100,451 | 17,513 | -82,938 | 0.04 | 0.01 | -0.03 | sell |
| Quantbot Technologies LP | 19,887 | 16,957 | -2,930 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,580 | 16,662 | +3,082 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,056 | 15,891 | -4,165 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,342 | 14,341 | +2,999 | 0.00 | 0.00 | +0.00 | buy |
| GREENLEAF TRUST | 13,623 | 13,719 | +96 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 32,367 | 13,696 | -18,671 | 0.01 | 0.00 | -0.00 | sell |
| McAdam, LLC | 14,244 | 13,491 | -753 | 0.01 | 0.01 | +0.00 | sell |
| Arizona State Retirement System | 0 | 12,501 | +12,501 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 12,700 | 11,885 | -815 | 0.10 | 0.09 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 11,342 | +11,342 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 11,091 | +11,091 | 0.00 | 0.03 | +0.03 | buy |