| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 8,656,038 | 8,656,038 | 0 | 1.55 | 1.94 | +0.39 | hold |
| Caligan Partners LP | 8,118,892 | 8,118,892 | 0 | 25.63 | 21.67 | -3.96 | hold |
| BlackRock, Inc. | 5,488,363 | 5,489,144 | +781 | 0.00 | 0.00 | +0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 2,851,449 | 3,502,112 | +650,663 | 32.68 | 38.93 | +6.25 | buy |
| Opaleye Management Inc. | 2,435,000 | 2,545,000 | +110,000 | 11.21 | 11.70 | +0.49 | buy |
| BANK OF AMERICA CORP /DE/ | 1,927,420 | 2,287,792 | +360,372 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,620,811 | 1,928,969 | +308,158 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,808,859 | 1,881,599 | +72,740 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,400,869 | 1,405,158 | +4,289 | 5.53 | 4.10 | -1.43 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 262,106 | 1,001,081 | +738,975 | 0.01 | 0.05 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,111 | 953,151 | +916,040 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,667,382 | 873,065 | -794,317 | 0.04 | 0.03 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 704,097 | 811,990 | +107,893 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 417,638 | 795,884 | +378,246 | 0.02 | 0.03 | +0.02 | buy |
| Eversept Partners, LP | 509,443 | 677,392 | +167,949 | 0.99 | 1.68 | +0.70 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 613,548 | 625,048 | +11,500 | 0.54 | 0.54 | +0.00 | buy |
| FMR LLC | 378,344 | 582,200 | +203,856 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 560,829 | 579,875 | +19,046 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 350,048 | 563,233 | +213,185 | 0.02 | 0.02 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 561,745 | 557,200 | -4,545 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 420,621 | 481,446 | +60,825 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 486,333 | 438,767 | -47,566 | 0.03 | 0.03 | -0.00 | sell |
| Trexquant Investment LP | 279,138 | 409,259 | +130,121 | 0.09 | 0.11 | +0.03 | buy |
| TCG Crossover Management, LLC | 1,710,084 | 403,048 | -1,307,036 | 1.95 | 0.44 | -1.52 | sell |
| Pale Fire Capital SE | 379,392 | 388,377 | +8,985 | 1.69 | 1.29 | -0.40 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 329,200 | 372,100 | +42,900 | 0.42 | 0.41 | -0.00 | buy |
| MORGAN STANLEY | 473,532 | 344,671 | -128,861 | 0.00 | 0.00 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 355,200 | 296,000 | -59,200 | 2.13 | 1.72 | -0.41 | sell |
| MARSHALL WACE, LLP | 145,639 | 289,439 | +143,800 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 306,957 | 279,475 | -27,482 | 0.01 | 0.01 | -0.00 | sell |
| Capricorn Fund Managers Ltd | 0 | 247,405 | +247,405 | 0.00 | 1.46 | +1.46 | buy |
| UBS Group AG | 111,762 | 207,237 | +95,475 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 112,380 | 204,060 | +91,680 | 0.06 | 0.12 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 233,144 | 199,060 | -34,084 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 121,661 | 195,116 | +73,455 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 198,693 | 193,920 | -4,773 | 0.00 | 0.00 | +0.00 | sell |
| Diametric Capital, LP | 91,489 | 167,760 | +76,271 | 0.85 | 1.66 | +0.81 | buy |
| RAYMOND JAMES FINANCIAL INC | 84,426 | 162,456 | +78,030 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 67,894 | 161,689 | +93,795 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 151,163 | 152,225 | +1,062 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 800,196 | 151,014 | -649,182 | 0.02 | 0.00 | -0.01 | sell |
| Greenland Capital Management LP | 131,500 | 150,000 | +18,500 | 0.66 | 1.13 | +0.48 | buy |
| Insight Wealth Strategies, LLC | 141,818 | 142,402 | +584 | 0.56 | 0.60 | +0.04 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 157,241 | 142,241 | -15,000 | 0.04 | 0.04 | -0.00 | sell |
| Aquatic Capital Management LLC | 26,362 | 140,331 | +113,969 | 0.03 | 0.15 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 187,814 | 137,652 | -50,162 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 118,800 | 120,400 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON ASSOCIATES LLP | 155,006 | 117,075 | -37,931 | 0.11 | 0.10 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 147,256 | 116,614 | -30,642 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 124,982 | 114,909 | -10,073 | 0.21 | 0.23 | +0.02 | sell |
| LGT Fund Management Co Ltd. | 0 | 110,250 | +110,250 | 0.00 | 0.18 | +0.18 | buy |
| Woodline Partners LP | 100,160 | 100,160 | 0 | 0.01 | 0.01 | +0.00 | hold |
| HighVista Strategies LLC | 156,003 | 99,744 | -56,259 | 1.39 | 1.04 | -0.35 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 7,984 | 98,357 | +90,373 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 96,717 | +96,717 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 146,569 | 94,750 | -51,819 | 0.00 | 0.00 | -0.00 | sell |
| AWH Capital, L.P. | 92,500 | 92,500 | 0 | 2.94 | 3.17 | +0.23 | hold |
| PATHWAY CAPITAL MANAGEMENT, LP | 0 | 91,384 | +91,384 | 0.00 | 80.26 | +80.26 | buy |
| Russell Investments Group, Ltd. | 74,778 | 86,890 | +12,112 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 168,176 | 86,687 | -81,489 | 0.02 | 0.01 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 459,766 | 80,280 | -379,486 | 0.02 | 0.00 | -0.02 | sell |
| RHUMBLINE ADVISERS | 78,489 | 80,000 | +1,511 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 78,171 | +78,171 | 0.00 | 0.47 | +0.47 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 532,425 | 75,602 | -456,823 | 0.06 | 0.01 | -0.05 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 57,670 | 72,895 | +15,225 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,953 | 72,438 | +14,485 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 68,650 | 69,653 | +1,003 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 85,646 | 69,640 | -16,006 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 72,665 | 64,935 | -7,730 | 0.04 | 0.03 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 62,195 | 61,019 | -1,176 | 0.00 | 0.01 | +0.00 | sell |
| Verition Fund Management LLC | 75,000 | 60,111 | -14,889 | 0.01 | 0.02 | +0.01 | sell |
| Sigma Planning Corp | 63,030 | 60,085 | -2,945 | 0.06 | 0.06 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,673 | 58,265 | +22,592 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 56,700 | +56,700 | 0.00 | 0.01 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 55,938 | +55,938 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 101,848 | 53,625 | -48,223 | 0.04 | 0.03 | -0.02 | sell |
| WCG Wealth Advisors LLC | 54,411 | 51,901 | -2,510 | 0.05 | 0.05 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 49,041 | +49,041 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,966 | 48,986 | +35,020 | 0.00 | 0.00 | +0.00 | buy |
| BURNEY CO/ | 0 | 48,481 | +48,481 | 0.00 | 0.06 | +0.06 | buy |
| Exome Asset Management LLC | 91,148 | 45,796 | -45,352 | 1.55 | 1.02 | -0.54 | sell |
| TD ASSET MANAGEMENT INC | 0 | 41,944 | +41,944 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40,135 | 40,595 | +460 | 0.10 | 0.12 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 56,741 | 40,263 | -16,478 | 0.01 | 0.01 | -0.00 | sell |
| Creative Planning | 35,828 | 40,031 | +4,203 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 39,423 | +39,423 | 0.00 | 0.01 | +0.01 | buy |
| SAPIENT CAPITAL LLC | 49,600 | 37,000 | -12,600 | 0.02 | 0.02 | -0.00 | sell |
| MetLife Investment Management, LLC | 36,899 | 36,685 | -214 | 0.01 | 0.01 | +0.00 | sell |
| SEI INVESTMENTS CO | 8,776 | 35,655 | +26,879 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 63,176 | 35,406 | -27,770 | 0.19 | 0.08 | -0.10 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 34,222 | +34,222 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 33,190 | 34,123 | +933 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,081 | 34,093 | +6,012 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 54,696 | 34,088 | -20,608 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 131,814 | 32,807 | -99,007 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,850 | 30,809 | +959 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 20,275 | 29,999 | +9,724 | 0.01 | 0.02 | +0.01 | buy |
| Whitcomb & Hess, Inc. | 28,232 | 29,945 | +1,713 | 0.25 | 0.26 | +0.01 | buy |
| LGL PARTNERS, LLC | 14,500 | 29,000 | +14,500 | 0.21 | 0.45 | +0.24 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 30,489 | 28,745 | -1,744 | 0.00 | 0.00 | +0.00 | sell |