| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CenterBook Partners LP | 121,072 | 1,103,850 | +982,778 | 0.11 | 0.76 | +0.65 | buy |
| TWO SIGMA INVESTMENTS, LP | 434,090 | 746,998 | +312,908 | 0.02 | 0.02 | 0.00 | buy |
| Whitefort Capital Management, LP | 1,050,180 | 1,331,602 | +281,422 | 7.29 | 6.42 | -0.87 | buy |
| Opaleye Management Inc. | 2,260,000 | 2,475,000 | +215,000 | 7.42 | 6.24 | -1.18 | buy |
| Eversept Partners, LP | 150,480 | 358,828 | +208,348 | 0.23 | 0.41 | +0.19 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 30,000 | 170,000 | +140,000 | 0.00 | 0.02 | +0.02 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 2,890,000 | 3,000,000 | +110,000 | 20.50 | 18.32 | -2.18 | buy |
| Woodline Partners LP | 300,160 | 400,160 | +100,000 | 0.03 | 0.03 | -0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 250,900 | 321,200 | +70,300 | 0.18 | 0.17 | -0.01 | buy |
| Diametric Capital, LP | 86,158 | 148,601 | +62,443 | 1.51 | 0.99 | -0.52 | buy |
| Alpine Global Management, LLC | 76,955 | 109,707 | +32,752 | 0.30 | 0.31 | +0.01 | buy |
| Greenland Capital Management LP | 45,000 | 72,500 | +27,500 | 0.11 | 0.12 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 33,709 | 58,140 | +24,431 | 0.04 | 0.07 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 1,639,351 | 1,631,948 | +7,403 | 0.01 | 0.01 | 0.00 | sell |
| Whitcomb & Hess, Inc. | 21,300 | 27,827 | +6,527 | 0.10 | 0.10 | +0.00 | buy |
| Quarry LP | 5,389 | 7,434 | +2,045 | 0.02 | 0.02 | 0.00 | buy |
| Ballentine Partners, LLC | 11,020 | 12,139 | +1,119 | 0.00 | 0.00 | -0.00 | buy |
| Caligan Partners LP | 8,118,592 | 8,118,892 | +300 | 24.99 | 19.64 | -5.35 | buy |
| GREENLEAF TRUST | 14,016 | 14,087 | +71 | 0.00 | 0.00 | -0.00 | buy |
| Bleakley Financial Group, LLC | 25,308 | 25,230 | -78 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 12,699 | 12,212 | -487 | 0.01 | 0.01 | -0.00 | sell |
| DMC Group, LLC | 16,881 | 15,719 | -1,162 | 0.20 | 0.15 | -0.05 | sell |
| Significant Wealth Partners LLC | 14,396 | 11,240 | -3,156 | 0.11 | 0.07 | -0.04 | sell |
| Virtus Investment Advisers, LLC | 14,910 | 6,507 | -8,403 | 0.06 | 0.03 | -0.03 | sell |
| Cinctive Capital Management LP | 60,499 | 27,786 | -32,713 | 0.07 | 0.02 | -0.05 | sell |
| SAPIENT CAPITAL LLC | 122,200 | 75,750 | -46,450 | 0.04 | 0.02 | -0.02 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 500,000 | 451,232 | -48,768 | 0.30 | 0.58 | +0.28 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,200,000 | 1,143,759 | -56,241 | 0.98 | 0.72 | -0.26 | sell |
| Velan Capital Investment Management LP | 300,000 | 239,260 | -60,740 | 4.55 | 2.98 | -1.57 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 153,482 | 75,876 | -77,606 | 2.63 | 1.32 | -1.31 | sell |
| HARBERT FUND ADVISORS, INC. | 339,158 | 259,811 | -79,347 | 5.67 | 9.71 | +4.04 | sell |
| HighVista Strategies LLC | 203,510 | 120,641 | -82,869 | 1.16 | 0.55 | -0.60 | sell |
| Kynam Capital Management, LP | 633,802 | 200,047 | -433,755 | 0.80 | 0.27 | -0.53 | sell |
| Patient Square Capital LP | 1,522,452 | 1,020,000 | -502,452 | 9.29 | 4.58 | -4.71 | sell |