| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 8,118,592 | 8,118,892 | +300 | 24.99 | 19.64 | -5.35 | buy |
| BlackRock, Inc. | 4,731,960 | 4,892,135 | +160,175 | 0.00 | 0.00 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,990,956 | 4,238,762 | +247,806 | 0.32 | 0.24 | -0.08 | buy |
| VANGUARD GROUP INC | 3,466,640 | 3,593,558 | +126,918 | 0.00 | 0.00 | -0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 2,890,000 | 3,000,000 | +110,000 | 20.50 | 18.32 | -2.18 | buy |
| Opaleye Management Inc. | 2,260,000 | 2,475,000 | +215,000 | 7.42 | 6.24 | -1.18 | buy |
| GOLDMAN SACHS GROUP INC | 861,231 | 2,417,005 | +1,555,774 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,787,707 | 1,830,701 | +42,994 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,639,351 | 1,631,948 | -7,403 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,616,778 | 1,616,778 | 0 | 0.47 | 0.37 | -0.11 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,373,248 | 1,405,747 | +32,499 | 0.00 | 0.00 | -0.00 | buy |
| Whitefort Capital Management, LP | 1,050,180 | 1,331,602 | +281,422 | 7.29 | 6.42 | -0.87 | buy |
| Tyro Capital Management LLC | 0 | 1,241,839 | +1,241,839 | 0.00 | 6.07 | +6.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,200,000 | 1,143,759 | -56,241 | 0.98 | 0.72 | -0.26 | sell |
| CenterBook Partners LP | 121,072 | 1,103,850 | +982,778 | 0.11 | 0.76 | +0.65 | buy |
| Patient Square Capital LP | 1,522,452 | 1,020,000 | -502,452 | 9.29 | 4.58 | -4.71 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 750,787 | 999,609 | +248,822 | 0.02 | 0.02 | +0.00 | buy |
| FMR LLC | 920,239 | 914,488 | -5,751 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 434,090 | 746,998 | +312,908 | 0.01 | 0.02 | +0.00 | buy |
| Shay Capital LLC | 0 | 705,758 | +705,758 | 0.00 | 2.00 | +2.00 | buy |
| MARSHALL WACE, LLP | 416,527 | 660,762 | +244,235 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 662,873 | 658,888 | -3,985 | 0.34 | 0.25 | -0.09 | sell |
| Hudson Bay Capital Management LP | 0 | 588,556 | +588,556 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 584,256 | 582,065 | -2,191 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 187,718 | 482,822 | +295,104 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 500,000 | 451,232 | -48,768 | 0.30 | 0.59 | +0.29 | sell |
| MORGAN STANLEY | 691,330 | 440,892 | -250,438 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 421,000 | 434,900 | +13,900 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 300,160 | 400,160 | +100,000 | 0.03 | 0.03 | -0.00 | buy |
| CITADEL ADVISORS LLC | 506,558 | 370,951 | -135,607 | 0.01 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 150,480 | 358,828 | +208,348 | 0.25 | 0.45 | +0.20 | buy |
| TWO SIGMA ADVISERS, LP | 287,800 | 324,400 | +36,600 | 0.01 | 0.01 | -0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 250,900 | 321,200 | +70,300 | 0.18 | 0.17 | -0.01 | buy |
| UBS Group AG | 207,418 | 274,648 | +67,230 | 0.00 | 0.00 | +0.00 | buy |
| HARBERT FUND ADVISORS, INC. | 339,158 | 259,811 | -79,347 | 5.80 | 9.71 | +3.91 | sell |
| Velan Capital Investment Management LP | 300,000 | 239,260 | -60,740 | 4.55 | 2.98 | -1.57 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 196,226 | 203,978 | +7,752 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 194,131 | 202,745 | +8,614 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 633,802 | 200,047 | -433,755 | 0.80 | 0.27 | -0.53 | sell |
| LB Partners LLC | 200,000 | 200,000 | 0 | 2.12 | 1.59 | -0.53 | hold |
| BANK OF AMERICA CORP /DE/ | 746,872 | 189,537 | -557,335 | 0.00 | 0.00 | -0.00 | sell |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 30,000 | 170,000 | +140,000 | 0.00 | 0.02 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 201,103 | 161,685 | -39,418 | 0.14 | 0.08 | -0.06 | sell |
| BARCLAYS PLC | 84,722 | 156,360 | +71,638 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 179,085 | 154,630 | -24,455 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 86,158 | 148,601 | +62,443 | 1.51 | 0.99 | -0.52 | buy |
| D. E. Shaw & Co., Inc. | 164,374 | 146,439 | -17,935 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 144,826 | +144,826 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 98,400 | 122,200 | +23,800 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 203,510 | 120,641 | -82,869 | 1.16 | 0.55 | -0.60 | sell |
| SIMPLEX TRADING, LLC | 79,027 | 120,309 | +41,282 | 0.04 | 0.04 | -0.00 | buy |
| Verition Fund Management LLC | 31,246 | 120,000 | +88,754 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 119,179 | +119,179 | 0.00 | 0.06 | +0.06 | buy |
| DG Capital Management, LLC | 0 | 118,995 | +118,995 | 0.00 | 0.70 | +0.70 | buy |
| Alpine Global Management, LLC | 76,955 | 109,707 | +32,752 | 0.30 | 0.31 | +0.01 | buy |
| Legal & General Group Plc | 83,041 | 94,152 | +11,111 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 33,521 | 93,328 | +59,807 | 0.01 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 85,463 | 91,689 | +6,226 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 90,049 | 90,672 | +623 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 0 | 90,000 | +90,000 | 0.00 | 0.51 | +0.51 | buy |
| Pale Fire Capital SE | 0 | 85,700 | +85,700 | 0.00 | 0.11 | +0.11 | buy |
| Advisory Services Network, LLC | 67,180 | 76,065 | +8,885 | 0.02 | 0.02 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 153,482 | 75,876 | -77,606 | 2.63 | 1.32 | -1.31 | sell |
| SAPIENT CAPITAL LLC | 122,200 | 75,750 | -46,450 | 0.04 | 0.02 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 120,369 | 74,401 | -45,968 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 73,034 | +73,034 | 0.00 | 0.00 | +0.00 | buy |
| Greenland Capital Management LP | 45,000 | 72,500 | +27,500 | 0.11 | 0.12 | +0.00 | buy |
| Anson Funds Management LP | 0 | 71,451 | +71,451 | 0.00 | 0.16 | +0.16 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 71,071 | +71,071 | 0.00 | 1.10 | +1.10 | buy |
| AWH Capital, L.P. | 0 | 69,500 | +69,500 | 0.00 | 1.01 | +1.01 | buy |
| Russell Investments Group, Ltd. | 91,997 | 69,263 | -22,734 | 0.00 | 0.00 | -0.00 | sell |
| Sigma Planning Corp | 65,275 | 69,185 | +3,910 | 0.03 | 0.03 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,150 | 66,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF MONTREAL /CAN/ | 65,686 | 65,587 | -99 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 62,235 | +62,235 | 0.00 | 0.02 | +0.02 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 170,176 | 61,682 | -108,494 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 11,936 | 61,584 | +49,648 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 33,709 | 58,140 | +24,431 | 0.05 | 0.07 | +0.02 | buy |
| SG Americas Securities, LLC | 61,735 | 56,363 | -5,372 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 293,627 | 55,013 | -238,614 | 0.01 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,928 | 51,285 | -643 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.61 | +0.61 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 121,756 | 47,896 | -73,860 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 41,999 | 42,090 | +91 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 30,979 | 41,280 | +10,301 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 45,670 | 40,386 | -5,284 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 58,495 | 40,167 | -18,328 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 38,077 | 39,008 | +931 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 38,091 | +38,091 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 0 | 37,793 | +37,793 | 0.00 | 0.04 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 37,894 | 37,638 | -256 | 0.01 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 53,575 | 37,515 | -16,060 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,065 | 36,453 | +388 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,681 | 35,188 | -2,493 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 649,037 | 34,630 | -614,407 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,879 | 32,698 | -37,181 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,377 | 32,057 | +4,680 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 62,523 | 32,030 | -30,493 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 29,922 | +29,922 | 0.00 | 0.12 | +0.12 | buy |
| Caption Management, LLC | 0 | 29,100 | +29,100 | 0.00 | 0.03 | +0.03 | buy |