| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,489,144 | 10,788,586 | +5,299,442 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 8,656,038 | 8,365,038 | -291,000 | 1.94 | 3.90 | +1.97 | sell |
| Caligan Partners LP | 8,118,892 | 8,118,892 | 0 | 21.67 | 31.23 | +9.56 | hold |
| FINDELL CAPITAL MANAGEMENT LLC | 3,502,112 | 3,502,112 | 0 | 38.93 | 46.03 | +7.10 | hold |
| STATE STREET CORP | 1,881,599 | 3,030,395 | +1,148,796 | 0.00 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 2,545,000 | 2,447,500 | -97,500 | 11.70 | 17.67 | +5.97 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,928,969 | 2,121,290 | +192,321 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,287,792 | 1,991,566 | -296,226 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 953,151 | 1,940,364 | +987,213 | 0.00 | 0.02 | +0.01 | buy |
| MPM BioImpact LLC | 1,405,158 | 1,386,174 | -18,984 | 4.10 | 6.74 | +2.64 | sell |
| D. E. Shaw & Co., Inc. | 873,065 | 1,267,706 | +394,641 | 0.03 | 0.06 | +0.04 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 0 | 1,209,604 | +1,209,604 | 0.00 | 0.26 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 811,990 | 958,892 | +146,902 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 438,767 | 816,187 | +377,420 | 0.03 | 0.09 | +0.07 | buy |
| NORTHERN TRUST CORP | 579,875 | 709,063 | +129,188 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 674,033 | +674,033 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 557,200 | 674,033 | +116,833 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 344,671 | 658,441 | +313,770 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 625,048 | 622,716 | -2,332 | 0.54 | 0.93 | +0.38 | sell |
| UBS Group AG | 207,237 | 606,558 | +399,321 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 582,200 | 595,629 | +13,429 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 542,131 | +542,131 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,001,081 | 471,067 | -530,014 | 0.05 | 0.03 | -0.02 | sell |
| Eversept Partners, LP | 677,392 | 428,652 | -248,740 | 1.68 | 1.86 | +0.18 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 372,100 | 406,400 | +34,300 | 0.41 | 0.67 | +0.25 | buy |
| Invesco Ltd. | 481,446 | 405,090 | -76,356 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 193,920 | 372,434 | +178,514 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 343,444 | +343,444 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 152,225 | 316,498 | +164,273 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 279,475 | 301,432 | +21,957 | 0.01 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 563,233 | 266,829 | -296,404 | 0.02 | 0.02 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 241,376 | +241,376 | 0.00 | 0.05 | +0.05 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 240,752 | +240,752 | 0.00 | 0.07 | +0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 239,557 | +239,557 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 8,100 | 232,353 | +224,253 | 0.00 | 0.03 | +0.03 | buy |
| RAYMOND JAMES FINANCIAL INC | 162,456 | 225,868 | +63,412 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 96,717 | 210,365 | +113,648 | 0.02 | 0.09 | +0.07 | buy |
| ALGERT GLOBAL LLC | 204,060 | 191,841 | -12,219 | 0.12 | 0.18 | +0.07 | sell |
| Capricorn Fund Managers Ltd | 247,405 | 182,205 | -65,200 | 1.46 | 1.16 | -0.29 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 199,060 | 176,135 | -22,925 | 0.00 | 0.00 | +0.00 | sell |
| Greenland Capital Management LP | 150,000 | 172,000 | +22,000 | 1.13 | 2.59 | +1.46 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 170,386 | +170,386 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 94,750 | 166,891 | +72,141 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 137,652 | 163,621 | +25,969 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 80,000 | 161,976 | +81,976 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 69,640 | 159,790 | +90,150 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 195,116 | 145,612 | -49,504 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 86,890 | 142,918 | +56,028 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 795,884 | 141,541 | -654,343 | 0.03 | 0.01 | -0.03 | sell |
| APIS CAPITAL ADVISORS, LLC | 296,000 | 140,000 | -156,000 | 1.72 | 1.09 | -0.64 | sell |
| BARCLAYS PLC | 32,807 | 130,863 | +98,056 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 120,400 | 128,100 | +7,700 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 100,160 | 125,160 | +25,000 | 0.01 | 0.03 | +0.02 | buy |
| Insight Wealth Strategies, LLC | 142,402 | 124,067 | -18,335 | 0.60 | 0.96 | +0.36 | sell |
| PRUDENTIAL FINANCIAL INC | 80,280 | 122,836 | +42,556 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 116,614 | 121,911 | +5,297 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 117,620 | +117,620 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 409,259 | 110,628 | -298,631 | 0.11 | 0.05 | -0.06 | sell |
| Diametric Capital, LP | 167,760 | 105,781 | -61,979 | 1.66 | 0.90 | -0.76 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,019 | 98,858 | +37,839 | 0.01 | 0.02 | +0.01 | buy |
| HighVista Strategies LLC | 99,744 | 97,896 | -1,848 | 1.04 | 1.78 | +0.74 | sell |
| ALLIANCEBERNSTEIN L.P. | 69,653 | 96,553 | +26,900 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON ASSOCIATES LLP | 117,075 | 92,656 | -24,419 | 0.10 | 0.14 | +0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 14,691 | 87,896 | +73,205 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,986 | 85,415 | +36,429 | 0.00 | 0.00 | +0.00 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 142,241 | 78,789 | -63,452 | 0.04 | 0.04 | +0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 78,171 | 74,743 | -3,428 | 0.47 | 0.78 | +0.31 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 58,265 | 74,702 | +16,437 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,438 | 74,095 | +1,657 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 289,439 | 73,289 | -216,150 | 0.01 | 0.00 | -0.01 | sell |
| AWH Capital, L.P. | 92,500 | 73,000 | -19,500 | 3.17 | 3.99 | +0.82 | sell |
| LGT Fund Management Co Ltd. | 110,250 | 70,800 | -39,450 | 0.18 | 0.24 | +0.05 | sell |
| WELLS FARGO & COMPANY/MN | 25,653 | 67,217 | +41,564 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 98,357 | 63,875 | -34,482 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 34,123 | 61,694 | +27,571 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 17,610 | 60,962 | +43,352 | 0.00 | 0.02 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 57,800 | +57,800 | 0.00 | 0.01 | +0.01 | buy |
| Sigma Planning Corp | 60,085 | 57,590 | -2,495 | 0.06 | 0.12 | +0.05 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 21,031 | 54,603 | +33,572 | 0.00 | 0.02 | +0.01 | buy |
| BURNEY CO/ | 48,481 | 53,008 | +4,527 | 0.06 | 0.11 | +0.06 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 51,462 | +51,462 | 0.00 | 0.01 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 15,402 | 50,802 | +35,400 | 0.01 | 0.05 | +0.04 | buy |
| Creative Planning | 40,031 | 50,051 | +10,020 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 64,935 | 48,150 | -16,785 | 0.03 | 0.04 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 41,944 | 47,398 | +5,454 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 46,133 | +46,133 | 0.00 | 0.01 | +0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 13,306 | 45,502 | +32,196 | 0.03 | 0.19 | +0.16 | buy |
| Verition Fund Management LLC | 60,111 | 45,233 | -14,878 | 0.02 | 0.03 | +0.00 | sell |
| Mariner, LLC | 22,791 | 43,647 | +20,856 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 42,666 | +42,666 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 41,405 | +41,405 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 36,685 | 41,056 | +4,371 | 0.01 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 140,331 | 39,623 | -100,708 | 0.15 | 0.11 | -0.04 | sell |
| Exome Asset Management LLC | 45,796 | 39,224 | -6,572 | 1.02 | 1.93 | +0.91 | sell |
| Engineers Gate Manager LP | 53,625 | 36,213 | -17,412 | 0.03 | 0.04 | +0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 72,895 | 35,917 | -36,978 | 0.01 | 0.01 | -0.00 | sell |
| FIFTH THIRD BANCORP | 224 | 35,159 | +34,935 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 56,700 | 33,800 | -22,900 | 0.01 | 0.00 | -0.00 | sell |
| WCG Wealth Advisors LLC | 51,901 | 33,655 | -18,246 | 0.05 | 0.06 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,809 | 32,501 | +1,692 | 0.00 | 0.00 | +0.00 | buy |