| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 4,238,762 | 8,565,638 | +4,326,876 | 0.24 | 1.10 | +0.86 | buy |
| Caligan Partners LP | 8,118,892 | 8,118,892 | 0 | 19.64 | 25.62 | +5.98 | hold |
| BlackRock, Inc. | 4,892,135 | 5,228,806 | +336,671 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,593,558 | 3,961,217 | +367,659 | 0.00 | 0.00 | +0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 3,000,000 | 2,830,000 | -170,000 | 18.32 | 29.38 | +11.07 | sell |
| GOLDMAN SACHS GROUP INC | 2,417,005 | 2,782,285 | +365,280 | 0.00 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 2,475,000 | 2,615,000 | +140,000 | 6.24 | 8.41 | +2.17 | buy |
| STATE STREET CORP | 1,830,701 | 1,913,856 | +83,155 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 1,710,084 | +1,710,084 | 0.00 | 1.91 | +1.91 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,405,747 | 1,607,598 | +201,851 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 146,439 | 1,487,901 | +1,341,462 | 0.00 | 0.03 | +0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,143,759 | 1,143,759 | 0 | 0.72 | 1.00 | +0.28 | hold |
| MORGAN STANLEY | 440,892 | 1,006,707 | +565,815 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,579 | 974,703 | +954,124 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 914,488 | 907,679 | -6,809 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 999,609 | 870,013 | -129,596 | 0.02 | 0.03 | +0.01 | sell |
| JANE STREET GROUP, LLC | 55,013 | 773,296 | +718,283 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 189,537 | 765,346 | +575,809 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 658,888 | 696,194 | +37,306 | 0.25 | 0.40 | +0.15 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 482,822 | 651,274 | +168,452 | 0.00 | 0.01 | +0.01 | buy |
| Whitefort Capital Management, LP | 1,331,602 | 607,409 | -724,193 | 6.42 | 4.57 | -1.85 | sell |
| NORTHERN TRUST CORP | 582,065 | 596,902 | +14,837 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 434,900 | 562,605 | +127,705 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 552,831 | +552,831 | 0.00 | 0.04 | +0.04 | buy |
| Eversept Partners, LP | 358,828 | 486,021 | +127,193 | 0.45 | 0.85 | +0.40 | buy |
| CenterBook Partners LP | 1,103,850 | 484,849 | -619,001 | 0.76 | 0.54 | -0.22 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 484,753 | +484,753 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 370,951 | 449,564 | +78,613 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 746,998 | 434,101 | -312,897 | 0.02 | 0.02 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 420,800 | +420,800 | 0.00 | 2.11 | +2.11 | buy |
| UBS Group AG | 274,648 | 412,380 | +137,732 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 405,654 | +405,654 | 0.00 | 0.10 | +0.10 | buy |
| Patient Square Capital LP | 1,020,000 | 400,000 | -620,000 | 4.58 | 2.43 | -2.15 | sell |
| MARSHALL WACE, LLP | 660,762 | 332,289 | -328,473 | 0.01 | 0.01 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 321,200 | 321,200 | 0 | 0.17 | 0.28 | +0.11 | hold |
| FEDERATED HERMES, INC. | 0 | 320,597 | +320,597 | 0.00 | 0.01 | +0.01 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 451,232 | 247,405 | -203,827 | 0.59 | 0.49 | -0.10 | sell |
| Pale Fire Capital SE | 85,700 | 240,721 | +155,021 | 0.11 | 0.60 | +0.49 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 203,978 | 239,580 | +35,602 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 324,400 | 229,400 | -95,000 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 202,745 | 210,119 | +7,374 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 200,000 | +200,000 | 0.00 | 0.74 | +0.74 | buy |
| LB Partners LLC | 200,000 | 200,000 | 0 | 1.59 | 2.92 | +1.33 | hold |
| Greenland Capital Management LP | 72,500 | 189,728 | +117,228 | 0.12 | 0.63 | +0.52 | buy |
| HighVista Strategies LLC | 120,641 | 176,485 | +55,844 | 0.55 | 0.98 | +0.43 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 170,000 | 165,820 | -4,180 | 0.02 | 0.03 | +0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 161,685 | 161,685 | 0 | 0.08 | 0.06 | -0.03 | hold |
| Divisadero Street Capital Management, LP | 0 | 158,004 | +158,004 | 0.00 | 0.17 | +0.17 | buy |
| HARBERT FUND ADVISORS, INC. | 259,811 | 154,811 | -105,000 | 9.71 | 22.97 | +13.26 | sell |
| Nuveen, LLC | 154,630 | 154,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Capital LLC | 93,328 | 153,845 | +60,517 | 0.01 | 0.03 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,896 | 153,315 | +105,419 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 122,200 | 124,200 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| BLUEFIN CAPITAL MANAGEMENT, LLC | 0 | 120,944 | +120,944 | 0.00 | 1.19 | +1.19 | buy |
| JW Asset Management, LLC | 0 | 110,000 | +110,000 | 0.00 | 1.20 | +1.20 | buy |
| Diametric Capital, LP | 148,601 | 109,536 | -39,065 | 0.99 | 0.92 | -0.06 | sell |
| BARCLAYS PLC | 156,360 | 107,866 | -48,494 | 0.00 | 0.00 | +0.00 | sell |
| Knott David M Jr | 90,000 | 107,783 | +17,783 | 0.51 | 1.03 | +0.52 | buy |
| Woodline Partners LP | 400,160 | 100,160 | -300,000 | 0.03 | 0.01 | -0.02 | sell |
| Exome Asset Management LLC | 20,500 | 94,235 | +73,735 | 0.21 | 1.41 | +1.20 | buy |
| Legal & General Group Plc | 94,152 | 94,105 | -47 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 93,959 | +93,959 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 91,689 | 91,342 | -347 | 0.00 | 0.00 | +0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 89,086 | +89,086 | 0.00 | 0.15 | +0.15 | buy |
| AWH Capital, L.P. | 69,500 | 85,000 | +15,500 | 1.01 | 2.02 | +1.01 | buy |
| CITIGROUP INC | 40,167 | 82,352 | +42,185 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 120,000 | 80,476 | -39,524 | 0.01 | 0.01 | +0.00 | sell |
| Caption Management, LLC | 29,100 | 79,847 | +50,747 | 0.03 | 0.11 | +0.07 | buy |
| Invesco Ltd. | 34,630 | 79,612 | +44,982 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,285 | 79,080 | +27,795 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 38,091 | 77,580 | +39,489 | 0.01 | 0.03 | +0.02 | buy |
| Russell Investments Group, Ltd. | 69,263 | 74,678 | +5,415 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,698 | 74,129 | +41,431 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 69,185 | 70,935 | +1,750 | 0.03 | 0.05 | +0.02 | buy |
| Advisory Services Network, LLC | 76,065 | 69,080 | -6,985 | 0.02 | 0.02 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 67,557 | +67,557 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,150 | 67,050 | +900 | 0.00 | 0.00 | +0.00 | buy |
| SAPIENT CAPITAL LLC | 75,750 | 64,600 | -11,150 | 0.02 | 0.02 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 32,057 | 60,013 | +27,956 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 61,682 | 58,681 | -3,001 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 58,140 | 56,485 | -1,655 | 0.07 | 0.10 | +0.03 | sell |
| ExodusPoint Capital Management, LP | 0 | 51,375 | +51,375 | 0.00 | 0.02 | +0.02 | buy |
| Rangeley Capital, LLC | 0 | 51,000 | +51,000 | 0.00 | 1.09 | +1.09 | buy |
| Soleus Capital Management, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 40,386 | 46,363 | +5,977 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 705,758 | 44,500 | -661,258 | 2.00 | 0.18 | -1.82 | sell |
| MARK ASSET MANAGEMENT LP | 25,500 | 43,756 | +18,256 | 0.04 | 0.10 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 41,280 | 41,306 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 90,672 | 40,150 | -50,522 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 37,515 | 39,064 | +1,549 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,008 | 39,008 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 38,621 | +38,621 | 0.00 | 0.07 | +0.07 | buy |
| Cetera Investment Advisers | 42,090 | 37,638 | -4,452 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 56,363 | 37,289 | -19,074 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,453 | 36,375 | -78 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 37,638 | 32,229 | -5,409 | 0.00 | 0.01 | +0.00 | sell |
| Jump Financial, LLC | 0 | 32,080 | +32,080 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 588,556 | 30,180 | -558,376 | 0.05 | 0.00 | -0.04 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,188 | 29,836 | -5,352 | 0.00 | 0.00 | +0.00 | sell |
| Whitcomb & Hess, Inc. | 27,827 | 28,385 | +558 | 0.10 | 0.17 | +0.07 | buy |