| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 8,118,592 | 8,118,592 | 0 | 25.73 | 29.26 | +3.52 | hold |
| BlackRock, Inc. | 4,205,723 | 4,661,563 | +455,840 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,441,929 | 3,557,296 | +115,367 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,290,956 | 3,290,956 | 0 | 0.18 | 0.20 | +0.02 | hold |
| FINDELL CAPITAL MANAGEMENT LLC | 3,193,539 | 3,080,000 | -113,539 | 16.62 | 16.55 | -0.08 | sell |
| Kynam Capital Management, LP | 2,266,328 | 2,266,328 | 0 | 1.76 | 1.76 | +0.00 | hold |
| Whitefort Capital Management, LP | 1,702,025 | 1,987,245 | +285,220 | 7.75 | 11.18 | +3.43 | buy |
| Patient Square Capital LP | 7,182,532 | 1,860,371 | -5,322,161 | 26.66 | 8.18 | -18.48 | sell |
| STATE STREET CORP | 2,175,378 | 1,811,753 | -363,625 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 1,500,000 | 1,760,000 | +260,000 | 1.18 | 1.23 | +0.04 | buy |
| Opaleye Management Inc. | 1,698,142 | 1,698,142 | 0 | 2.83 | 3.49 | +0.66 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,237,657 | 1,339,254 | +101,597 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 1,100,000 | +300,000 | 0.57 | 0.86 | +0.28 | buy |
| GOLDMAN SACHS GROUP INC | 260,467 | 778,276 | +517,809 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 25,231 | 700,171 | +674,940 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 493,540 | 589,921 | +96,381 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 137,949 | 571,305 | +433,356 | 0.11 | 0.69 | +0.59 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 558,658 | 558,658 | 0 | 0.17 | 0.20 | +0.03 | hold |
| JANUS HENDERSON GROUP PLC | 33,800 | 535,552 | +501,752 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 500,000 | +500,000 | 0.00 | 0.54 | +0.54 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 390,257 | 428,570 | +38,313 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 230,000 | 427,411 | +197,411 | 1.20 | 2.70 | +1.51 | buy |
| Woodline Partners LP | 414,892 | 421,683 | +6,791 | 0.04 | 0.03 | -0.00 | buy |
| MORGAN STANLEY | 334,845 | 413,347 | +78,502 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 147,444 | 392,564 | +245,120 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 314,103 | 381,237 | +67,134 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,153 | 346,654 | +155,501 | 0.00 | 0.01 | +0.00 | buy |
| HARBERT FUND ADVISORS, INC. | 339,158 | 339,158 | 0 | 2.73 | 3.47 | +0.74 | hold |
| Velan Capital Investment Management LP | 300,000 | 300,000 | 0 | 3.26 | 3.04 | -0.21 | hold |
| UBS Group AG | 62,657 | 287,327 | +224,670 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 148,696 | 286,289 | +137,593 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 250,900 | 250,900 | 0 | 0.13 | 0.14 | +0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 228,000 | +228,000 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 180,947 | 203,510 | +22,563 | 0.62 | 0.89 | +0.27 | buy |
| BANK OF AMERICA CORP /DE/ | 595,113 | 200,740 | -394,373 | 0.00 | 0.00 | -0.00 | sell |
| Maven Securities LTD | 400,000 | 200,000 | -200,000 | 0.45 | 0.38 | -0.07 | sell |
| LB Partners LLC | 200,000 | 200,000 | 0 | 1.74 | 1.76 | +0.03 | hold |
| Bank of New York Mellon Corp | 182,550 | 188,584 | +6,034 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 187,400 | 181,800 | -5,600 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 179,923 | 179,999 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 152,001 | 172,172 | +20,171 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 100,000 | 150,000 | +50,000 | 0.24 | 0.52 | +0.28 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 73,500 | 137,709 | +64,209 | 0.60 | 1.63 | +1.03 | buy |
| Diametric Capital, LP | 124,332 | 132,028 | +7,696 | 0.61 | 1.05 | +0.43 | buy |
| SAPIENT CAPITAL LLC | 133,600 | 122,200 | -11,400 | 0.03 | 0.03 | +0.00 | sell |
| BARCLAYS PLC | 99,984 | 117,085 | +17,101 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 110,233 | 110,459 | +226 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 89,500 | 107,900 | +18,400 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 83,289 | 105,734 | +22,445 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 235,887 | 98,834 | -137,053 | 0.09 | 0.04 | -0.05 | sell |
| Squarepoint Ops LLC | 107,156 | 98,189 | -8,967 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 106,359 | 91,541 | -14,818 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 75,000 | 90,500 | +15,500 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 257,945 | 89,651 | -168,294 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 140,190 | 86,882 | -53,308 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 84,376 | +84,376 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 49,059 | 83,305 | +34,246 | 0.03 | 0.03 | +0.01 | buy |
| Legal & General Group Plc | 73,063 | 83,286 | +10,223 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 80,933 | +80,933 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 77,911 | 80,652 | +2,741 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 75,201 | +75,201 | 0.00 | 0.07 | +0.07 | buy |
| Aquatic Capital Management LLC | 0 | 73,650 | +73,650 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 61,476 | 68,436 | +6,960 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 66,600 | 66,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Advisory Services Network, LLC | 57,790 | 66,445 | +8,655 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,150 | 66,150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 50,779 | 65,294 | +14,515 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 63,095 | 65,210 | +2,115 | 0.02 | 0.02 | +0.00 | buy |
| Cinctive Capital Management LP | 44,416 | 61,528 | +17,112 | 0.03 | 0.04 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 29,743 | 60,770 | +31,027 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 52,363 | +52,363 | 0.00 | 0.09 | +0.09 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,203 | 51,928 | +7,725 | 0.00 | 0.00 | +0.00 | buy |
| Anson Funds Management LP | 176,403 | 51,403 | -125,000 | 0.24 | 0.07 | -0.17 | sell |
| DEUTSCHE BANK AG\ | 33,285 | 51,075 | +17,790 | 0.00 | 0.00 | +0.00 | buy |
| SkyView Investment Advisors, LLC | 50,000 | 50,000 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Greenland Capital Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.12 | +0.12 | buy |
| Schonfeld Strategic Advisors LLC | 54,475 | 47,800 | -6,675 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 44,753 | +44,753 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 45,279 | 44,633 | -646 | 0.03 | 0.04 | +0.01 | sell |
| SIMPLEX TRADING, LLC | 13,562 | 40,234 | +26,672 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,544 | 39,348 | +19,804 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 38,619 | +38,619 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,551 | 38,520 | +4,969 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,566 | 35,981 | +4,415 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 34,580 | +34,580 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 32,302 | 31,791 | -511 | 0.02 | 0.03 | +0.01 | sell |
| Corebridge Financial, Inc. | 30,822 | 31,516 | +694 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 29,966 | 31,243 | +1,277 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,753 | 30,020 | +12,267 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 542,351 | 29,293 | -513,058 | 0.06 | 0.00 | -0.05 | sell |
| JPMORGAN CHASE & CO | 235,393 | 28,205 | -207,188 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,678 | 24,623 | +5,945 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 25,692 | 23,785 | -1,907 | 0.01 | 0.01 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,708 | 22,772 | +4,064 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,206 | 21,867 | -339 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,736 | 20,633 | +18,897 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,597 | 20,463 | -1,134 | 0.00 | 0.00 | +0.00 | sell |
| TORONTO DOMINION BANK | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 22,368 | 19,688 | -2,680 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,324 | 19,324 | 0 | 0.00 | 0.00 | +0.00 | hold |