| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 564,579 | 1,427,124 | +862,545 | 0.03 | 0.06 | +0.03 | buy |
| Vestal Point Capital, LP | 200,000 | 1,050,000 | +850,000 | 0.39 | 1.54 | +1.15 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 427,008 | +427,008 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | 1,568,266 | +379,642 | 4.23 | 4.48 | +0.25 | buy |
| WASATCH ADVISORS LP | 0 | 368,568 | +368,568 | 0.00 | 0.15 | +0.15 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 335,834 | +335,834 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,552,612 | 3,856,137 | +303,525 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 439,626 | 742,693 | +303,067 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,562,154 | 2,775,649 | +213,495 | 3.67 | 3.27 | -0.40 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 191,428 | +191,428 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 150,000 | +150,000 | 0.00 | 0.97 | +0.97 | buy |
| JPMORGAN CHASE & CO | 30,478 | 139,981 | +109,503 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 99,845 | +99,845 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 978,212 | 1,072,951 | +94,739 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 36,448 | 120,700 | +84,252 | 0.12 | 0.27 | +0.15 | buy |
| CITADEL ADVISORS LLC | 163,997 | 241,737 | +77,740 | 0.01 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 252,588 | 328,340 | +75,752 | 2.49 | 2.54 | +0.05 | buy |
| Freestone Grove Partners LP | 0 | 68,389 | +68,389 | 0.00 | 0.03 | +0.03 | buy |
| Deep Track Capital, LP | 3,600,000 | 3,666,768 | +66,768 | 5.21 | 3.40 | -1.81 | buy |
| Eversept Partners, LP | 0 | 55,710 | +55,710 | 0.00 | 0.19 | +0.19 | buy |
| Squarepoint Ops LLC | 241,033 | 295,824 | +54,791 | 0.04 | 0.04 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 53,636 | +53,636 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 225,179 | 277,087 | +51,908 | 0.93 | 0.85 | -0.08 | buy |
| XTX Topco Ltd | 51,634 | 95,130 | +43,496 | 0.06 | 0.08 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,210 | 54,671 | +43,461 | 0.01 | 0.07 | +0.05 | buy |
| Invesco Ltd. | 742,497 | 785,808 | +43,311 | 0.01 | 0.00 | -0.00 | buy |
| Atika Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.25 | +0.25 | buy |
| ORBIMED ADVISORS LLC | 0 | 35,581 | +35,581 | 0.00 | 0.04 | +0.04 | buy |
| HighVista Strategies LLC | 52,464 | 87,060 | +34,596 | 1.02 | 1.25 | +0.23 | buy |
| NORTHERN TRUST CORP | 352,957 | 386,611 | +33,654 | 0.00 | 0.00 | -0.00 | buy |
| Vontobel Holding Ltd. | 9,754 | 40,000 | +30,246 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 9,643 | 38,090 | +28,447 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 24,583 | +24,583 | 0.00 | 0.06 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 16,085 | 40,202 | +24,117 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 89,293 | 111,639 | +22,346 | 0.00 | 0.00 | -0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 22,053 | +22,053 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 23,661 | 44,152 | +20,491 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,078 | 36,038 | +16,960 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 16,672 | +16,672 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,635 | 33,290 | +16,655 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 49,094 | 65,096 | +16,002 | 0.01 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 15,219 | +15,219 | 0.00 | 0.01 | +0.01 | buy |
| WESBANCO BANK INC | 0 | 14,000 | +14,000 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 54,335 | 67,298 | +12,963 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 14,541 | 26,800 | +12,259 | 0.05 | 0.06 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,453 | 42,003 | +11,550 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 3,346,025 | 3,357,059 | +11,034 | 2.34 | 1.80 | -0.53 | buy |
| Verition Fund Management LLC | 4,460 | 15,000 | +10,540 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,616 | 51,029 | +10,413 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 9,541 | +9,541 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 34,647 | 43,365 | +8,718 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 28,004 | 36,658 | +8,654 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 8,800 | 17,300 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,378 | 18,771 | +8,393 | 0.20 | 0.28 | +0.07 | buy |
| Brevan Howard Capital Management LP | 0 | 7,993 | +7,993 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 106,782 | 114,458 | +7,676 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,162 | 335,834 | +7,672 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 0 | 7,121 | +7,121 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 4,021 | 10,864 | +6,843 | 0.02 | 0.04 | +0.03 | buy |
| RHUMBLINE ADVISERS | 46,958 | 52,718 | +5,760 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 24,669 | 29,659 | +4,990 | 0.09 | 0.10 | +0.01 | buy |
| Yorktown Management & Research Co Inc | 0 | 4,950 | +4,950 | 0.00 | 0.19 | +0.19 | buy |
| Quadrature Capital Ltd | 0 | 4,880 | +4,880 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 16,800 | 21,000 | +4,200 | 0.25 | 0.30 | +0.05 | buy |
| Pale Fire Capital SE | 5,652 | 9,802 | +4,150 | 0.03 | 0.04 | +0.01 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 19,704 | 23,796 | +4,092 | 0.03 | 0.02 | -0.00 | buy |
| Clearbridge Investments, LLC | 545,351 | 549,387 | +4,036 | 0.03 | 0.03 | -0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 4,018 | +4,018 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 3,808 | +3,808 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 3,712 | +3,712 | 0.00 | 0.01 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 42,087 | 45,794 | +3,707 | 0.08 | 0.07 | -0.01 | buy |
| Blueshift Asset Management, LLC | 0 | 3,697 | +3,697 | 0.00 | 0.05 | +0.05 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 3,799 | 7,429 | +3,630 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 1 | 3,446 | +3,445 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 35,918 | 39,303 | +3,385 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 4,687 | 8,004 | +3,317 | 0.05 | 0.08 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 3,242 | +3,242 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,896 | 27,743 | +2,847 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 21,794 | 24,493 | +2,699 | 0.01 | 0.01 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 2,431 | +2,431 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,272 | 13,285 | +2,013 | 0.71 | 0.58 | -0.12 | buy |
| Engineers Gate Manager LP | 2,855 | 4,755 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 7,479 | 9,357 | +1,878 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 3,367 | 5,111 | +1,744 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 1,643 | +1,643 | 0.00 | 0.01 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 12,769 | 14,275 | +1,506 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,986 | 12,354 | +1,368 | 0.01 | 0.01 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 363 | 1,644 | +1,281 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 2,960 | 4,190 | +1,230 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 13,800 | 15,000 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 11,604 | 12,696 | +1,092 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 4,022 | 4,993 | +971 | 0.01 | 0.01 | -0.00 | buy |
| Bayforest Capital Ltd | 703 | 1,641 | +938 | 0.06 | 0.10 | +0.04 | buy |
| JONES FINANCIAL COMPANIES LLLP | 5,156 | 6,083 | +927 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,404 | 38,198 | +794 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 6,225 | 6,930 | +705 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,556 | 19,206 | +650 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 634 | +634 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 3,272 | 3,801 | +529 | 0.01 | 0.01 | -0.00 | buy |
| XPONANCE, INC. | 3,684 | 4,128 | +444 | 0.00 | 0.00 | -0.00 | buy |