| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | 1,568,266 | +379,642 | 4.23 | 4.48 | +0.25 | buy |
| Rock Springs Capital Management LP | 225,179 | 277,087 | +51,908 | 0.93 | 0.85 | -0.08 | buy |
| HighVista Strategies LLC | 52,464 | 87,060 | +34,596 | 1.02 | 1.25 | +0.23 | buy |
| J. Goldman & Co LP | 14,541 | 26,800 | +12,259 | 0.03 | 0.04 | +0.01 | buy |
| RTW INVESTMENTS, LP | 3,346,025 | 3,357,059 | +11,034 | 2.34 | 1.80 | -0.53 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 19,704 | 23,796 | +4,092 | 0.03 | 0.02 | -0.00 | buy |
| Clearbridge Investments, LLC | 545,351 | 549,387 | +4,036 | 0.03 | 0.03 | -0.00 | buy |
| E. Ohman J:or Asset Management AB | 42,087 | 45,794 | +3,707 | 0.08 | 0.07 | -0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 4,687 | 8,004 | +3,317 | 0.05 | 0.08 | +0.03 | buy |
| Valeo Financial Advisors, LLC | 3,842 | 3,838 | -4 | 0.01 | 0.01 | -0.00 | sell |
| 1620 INVESTMENT ADVISORS, INC. | 1,784 | 1,721 | -63 | 0.08 | 0.07 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 7,552 | 6,847 | -705 | 0.04 | 0.03 | -0.01 | sell |
| MPM BioImpact LLC | 329,750 | 322,007 | -7,743 | 1.79 | 1.24 | -0.55 | sell |
| TimesSquare Capital Management, LLC | 388,590 | 369,377 | -19,213 | 100.00 | 100.00 | 0.00 | sell |
| Artisan Partners Limited Partnership | 307,307 | 284,899 | -22,408 | 0.03 | 0.03 | -0.01 | sell |
| Voleon Capital Management LP | 68,935 | 43,405 | -25,530 | 0.10 | 0.05 | -0.05 | sell |
| PDT Partners, LLC | 63,026 | 32,292 | -30,734 | 0.26 | 0.11 | -0.15 | sell |
| PFM Health Sciences, LP | 80,226 | 40,579 | -39,647 | 0.51 | 0.22 | -0.29 | sell |
| Cormorant Asset Management, LP | 225,000 | 100,000 | -125,000 | 0.79 | 0.32 | -0.47 | sell |