| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,025,000 | 2,863,406 | +1,838,406 | 0.97 | 3.66 | +2.69 | buy |
| JENNISON ASSOCIATES LLC | 0 | 1,330,938 | +1,330,938 | 0.00 | 0.03 | +0.03 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 74,000 | 898,000 | +824,000 | 0.01 | 0.11 | +0.11 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 609,104 | +609,104 | 0.00 | 4.48 | +4.48 | buy |
| Integral Health Asset Management, LLC | 100,000 | 590,000 | +490,000 | 0.29 | 2.11 | +1.81 | buy |
| MORGAN STANLEY | 1,957,688 | 2,398,918 | +441,230 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 347,683 | +347,683 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 437,891 | 727,891 | +290,000 | 0.02 | 0.05 | +0.03 | buy |
| Walleye Capital LLC | 0 | 272,498 | +272,498 | 0.00 | 0.11 | +0.11 | buy |
| Artisan Partners Limited Partnership | 390,011 | 627,430 | +237,419 | 0.01 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 1,595,501 | 1,826,632 | +231,131 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 518,519 | 710,277 | +191,758 | 2.87 | 7.02 | +4.15 | buy |
| STEMPOINT CAPITAL LP | 30,990 | 222,253 | +191,263 | 0.17 | 2.16 | +1.99 | buy |
| CITADEL ADVISORS LLC | 43,037 | 219,278 | +176,241 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 161,163 | +161,163 | 0.00 | 0.06 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 40,527 | 196,512 | +155,985 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 150,000 | +150,000 | 0.00 | 0.04 | +0.04 | buy |
| CIBC WORLD MARKET INC. | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| Baird Financial Group, Inc. | 0 | 128,272 | +128,272 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 97,873 | 223,569 | +125,696 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,152,341 | 3,272,341 | +120,000 | 1.00 | 1.76 | +0.76 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 111,422 | +111,422 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 100,658 | +100,658 | 0.00 | 0.57 | +0.57 | buy |
| Laurion Capital Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.10 | +0.10 | buy |
| J. Goldman & Co LP | 72,344 | 163,347 | +91,003 | 0.08 | 0.27 | +0.19 | buy |
| LORD, ABBETT & CO. LLC | 0 | 82,226 | +82,226 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 71,940 | 147,826 | +75,886 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,772 | 175,512 | +63,740 | 0.08 | 0.18 | +0.10 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,204,797 | 2,254,797 | +50,000 | 4.13 | 8.53 | +4.41 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.22 | +0.22 | buy |
| TD ASSET MANAGEMENT INC | 0 | 48,588 | +48,588 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 674,831 | 717,090 | +42,259 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 3,632 | 37,853 | +34,221 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 33,867 | +33,867 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 77 | 30,036 | +29,959 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 29,577 | +29,577 | 0.00 | 0.38 | +0.38 | buy |
| Jump Financial, LLC | 0 | 29,470 | +29,470 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 25,570 | 53,339 | +27,769 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 5,828 | 33,363 | +27,535 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 22,720 | +22,720 | 0.00 | 0.00 | +0.00 | buy |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 0 | 20,964 | +20,964 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 609,736 | 629,692 | +19,956 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 19,156 | 38,275 | +19,119 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,334 | 30,170 | +18,836 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,696 | +18,696 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 14,378 | 32,804 | +18,426 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 15,465 | +15,465 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 82,197 | 96,409 | +14,212 | 0.00 | 0.00 | +0.00 | buy |
| Alpha DNA Investment Management LLC | 0 | 13,913 | +13,913 | 0.00 | 0.28 | +0.28 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,518 | 39,479 | +12,961 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 11,620 | +11,620 | 0.00 | 0.06 | +0.06 | buy |
| Quantbot Technologies LP | 0 | 11,266 | +11,266 | 0.00 | 0.02 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 11,229 | +11,229 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 10,537 | +10,537 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,195 | +10,195 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 9,878 | +9,878 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 8,596 | +8,596 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,368 | 22,838 | +8,470 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,918 | 16,166 | +8,248 | 0.00 | 0.02 | +0.01 | buy |
| UBS Group AG | 30,493 | 38,340 | +7,847 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 7,631 | +7,631 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 66,300 | 73,900 | +7,600 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 7,197 | +7,197 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 90,083 | 97,047 | +6,964 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 20,660 | 27,300 | +6,640 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 6,595 | +6,595 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 6,147 | +6,147 | 0.00 | 0.01 | +0.01 | buy |
| Simplicity Wealth,LLC | 0 | 6,133 | +6,133 | 0.00 | 0.01 | +0.01 | buy |
| NATIONS FINANCIAL GROUP INC, /IA/ /ADV | 0 | 6,000 | +6,000 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 0 | 5,914 | +5,914 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 5,729 | +5,729 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 53,450 | 58,367 | +4,917 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 187,414 | 192,303 | +4,889 | 0.01 | 0.01 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 4,709 | +4,709 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 21,827 | 26,448 | +4,621 | 0.00 | 0.01 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 20,950 | 24,650 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 218,662 | 221,997 | +3,335 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 17,061 | 19,928 | +2,867 | 0.22 | 0.38 | +0.17 | buy |
| China Universal Asset Management Co., Ltd. | 3,832 | 6,567 | +2,735 | 0.02 | 0.03 | +0.02 | buy |
| Aquatic Capital Management LLC | 4,700 | 7,200 | +2,500 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 11,980 | 14,122 | +2,142 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,863 | 11,874 | +2,011 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,620 | 43,590 | +1,970 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 1,900 | +1,900 | 0.00 | 0.17 | +0.17 | buy |
| Trexquant Investment LP | 39,497 | 41,038 | +1,541 | 0.02 | 0.03 | +0.01 | buy |
| Swiss National Bank | 41,833 | 42,433 | +600 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 11,051 | 11,519 | +468 | 0.00 | 0.00 | +0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 0 | 224 | +224 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 1,617 | 1,759 | +142 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 21 | 132 | +111 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 14,263 | 14,352 | +89 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 66 | 133 | +67 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 10 | 41 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 0 | 2 | +2 | 0.00 | 0.00 | 0.00 | buy |