| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,152,341 | 3,272,341 | +120,000 | 1.00 | 1.76 | +0.76 | buy |
| Paradigm Biocapital Advisors LP | 1,025,000 | 2,863,406 | +1,838,406 | 0.97 | 3.66 | +2.69 | buy |
| MORGAN STANLEY | 1,957,688 | 2,398,918 | +441,230 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,204,797 | 2,254,797 | +50,000 | 4.13 | 8.53 | +4.41 | buy |
| Cormorant Asset Management, LP | 2,221,422 | 2,139,102 | -82,320 | 2.15 | 3.43 | +1.27 | sell |
| VANGUARD GROUP INC | 1,595,501 | 1,826,632 | +231,131 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,787,527 | 1,787,527 | 0 | 1.94 | 2.74 | +0.81 | hold |
| JENNISON ASSOCIATES LLC | 0 | 1,330,938 | +1,330,938 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 1,296,416 | 0 | 0.59 | 0.83 | +0.24 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 74,000 | 898,000 | +824,000 | 0.01 | 0.11 | +0.11 | buy |
| TCG Crossover Management, LLC | 1,142,857 | 793,829 | -349,028 | 2.57 | 2.28 | -0.29 | sell |
| Ensign Peak Advisors, Inc | 437,891 | 727,891 | +290,000 | 0.02 | 0.05 | +0.03 | buy |
| STATE STREET CORP | 674,831 | 717,090 | +42,259 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 518,519 | 710,277 | +191,758 | 2.87 | 7.02 | +4.15 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 609,736 | 629,692 | +19,956 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 390,011 | 627,430 | +237,419 | 0.01 | 0.03 | +0.02 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 609,104 | +609,104 | 0.00 | 4.48 | +4.48 | buy |
| Integral Health Asset Management, LLC | 100,000 | 590,000 | +490,000 | 0.29 | 2.11 | +1.81 | buy |
| Vivo Capital, LLC | 1,784,006 | 565,550 | -1,218,456 | 2.96 | 1.62 | -1.34 | sell |
| TFG Asset Management GP Ltd | 800,000 | 450,000 | -350,000 | 4.11 | 4.50 | +0.39 | sell |
| DIMENSIONAL FUND ADVISORS LP | 430,127 | 424,830 | -5,297 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 347,683 | +347,683 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 272,498 | +272,498 | 0.00 | 0.11 | +0.11 | buy |
| Jefferies Financial Group Inc. | 380,758 | 270,758 | -110,000 | 0.12 | 0.20 | +0.08 | sell |
| NORTHERN TRUST CORP | 248,750 | 247,177 | -1,573 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 238,823 | 229,492 | -9,331 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 97,873 | 223,569 | +125,696 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 30,990 | 222,253 | +191,263 | 0.17 | 2.16 | +1.99 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 218,662 | 221,997 | +3,335 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 43,037 | 219,278 | +176,241 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 232,900 | 215,958 | -16,942 | 0.06 | 0.10 | +0.04 | sell |
| GOLDMAN SACHS GROUP INC | 237,439 | 203,730 | -33,709 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 40,527 | 196,512 | +155,985 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 187,414 | 192,303 | +4,889 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,772 | 175,512 | +63,740 | 0.08 | 0.18 | +0.10 | buy |
| Sands Capital Alternatives, LLC | 260,000 | 170,000 | -90,000 | 1.46 | 1.49 | +0.03 | sell |
| J. Goldman & Co LP | 72,344 | 163,347 | +91,003 | 0.08 | 0.27 | +0.19 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 161,163 | +161,163 | 0.00 | 0.06 | +0.06 | buy |
| NORGES BANK | 160,100 | 160,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 375,276 | 150,321 | -224,955 | 0.76 | 0.54 | -0.23 | sell |
| CIBC WORLD MARKETS CORP | 0 | 150,000 | +150,000 | 0.00 | 0.04 | +0.04 | buy |
| MACQUARIE GROUP LTD | 150,000 | 150,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CIBC WORLD MARKET INC. | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 71,940 | 147,826 | +75,886 | 0.00 | 0.01 | +0.01 | buy |
| Baird Financial Group, Inc. | 0 | 128,272 | +128,272 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 111,422 | +111,422 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 100,658 | +100,658 | 0.00 | 0.57 | +0.57 | buy |
| Laurion Capital Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.10 | +0.10 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 90,083 | 97,047 | +6,964 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 82,197 | 96,409 | +14,212 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 82,226 | +82,226 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 66,300 | 73,900 | +7,600 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 72,032 | 72,032 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Exome Asset Management LLC | 84,400 | 66,300 | -18,100 | 1.69 | 2.06 | +0.37 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,423 | 60,994 | -30,429 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 53,450 | 58,367 | +4,917 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,570 | 53,339 | +27,769 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.22 | +0.22 | buy |
| TD ASSET MANAGEMENT INC | 0 | 48,588 | +48,588 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,620 | 43,590 | +1,970 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 41,833 | 42,433 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 39,497 | 41,038 | +1,541 | 0.02 | 0.03 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,518 | 39,479 | +12,961 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 30,493 | 38,340 | +7,847 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 19,156 | 38,275 | +19,119 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 3,632 | 37,853 | +34,221 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 33,867 | +33,867 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 5,828 | 33,363 | +27,535 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 14,378 | 32,804 | +18,426 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 47,259 | 30,308 | -16,951 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,334 | 30,170 | +18,836 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 77 | 30,036 | +29,959 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 29,577 | +29,577 | 0.00 | 0.38 | +0.38 | buy |
| Jump Financial, LLC | 0 | 29,470 | +29,470 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 20,660 | 27,300 | +6,640 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 21,827 | 26,448 | +4,621 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 198,454 | 25,644 | -172,810 | 0.00 | 0.00 | -0.00 | sell |
| E. Ohman J:or Asset Management AB | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| Cambridge Investment Research Advisors, Inc. | 20,950 | 24,650 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,368 | 22,838 | +8,470 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 22,831 | 22,831 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 22,720 | +22,720 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,590 | 22,281 | -1,309 | 0.00 | 0.00 | +0.00 | sell |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 0 | 20,964 | +20,964 | 0.00 | 0.07 | +0.07 | buy |
| Janney Montgomery Scott LLC | 24,227 | 20,901 | -3,326 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 17,061 | 19,928 | +2,867 | 0.22 | 0.38 | +0.17 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,696 | +18,696 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 17,754 | 17,754 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 7,918 | 16,166 | +8,248 | 0.00 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 15,540 | 15,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 179,514 | 15,531 | -163,983 | 0.03 | 0.00 | -0.03 | sell |
| FEDERATED HERMES, INC. | 0 | 15,465 | +15,465 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20,000 | 15,200 | -4,800 | 0.04 | 0.04 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 14,263 | 14,352 | +89 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,980 | 14,122 | +2,142 | 0.00 | 0.00 | +0.00 | buy |
| Alpha DNA Investment Management LLC | 0 | 13,913 | +13,913 | 0.00 | 0.28 | +0.28 | buy |
| WELLS FARGO & COMPANY/MN | 9,863 | 11,874 | +2,011 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 11,620 | +11,620 | 0.00 | 0.06 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 11,051 | 11,519 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 11,266 | +11,266 | 0.00 | 0.02 | +0.02 | buy |