| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,025,000 | 2,863,406 | +1,838,406 | 0.97 | 3.66 | +2.69 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 74,000 | 898,000 | +824,000 | 0.01 | 0.11 | +0.10 | buy |
| Integral Health Asset Management, LLC | 100,000 | 590,000 | +490,000 | 0.29 | 2.11 | +1.81 | buy |
| Artisan Partners Limited Partnership | 390,011 | 627,430 | +237,419 | 0.01 | 0.03 | +0.02 | buy |
| Ikarian Capital, LLC | 518,519 | 710,277 | +191,758 | 2.87 | 7.02 | +4.15 | buy |
| STEMPOINT CAPITAL LP | 30,990 | 222,253 | +191,263 | 0.17 | 2.16 | +1.99 | buy |
| RTW INVESTMENTS, LP | 3,152,341 | 3,272,341 | +120,000 | 1.00 | 1.76 | +0.76 | buy |
| J. Goldman & Co LP | 72,344 | 163,347 | +91,003 | 0.06 | 0.19 | +0.13 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,204,797 | 2,254,797 | +50,000 | 4.13 | 8.53 | +4.41 | buy |
| ExodusPoint Capital Management, LP | 232,900 | 215,958 | +16,942 | 0.06 | 0.10 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 90,083 | 97,047 | +6,964 | 0.01 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 21,827 | 26,448 | +4,621 | 0.00 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 17,061 | 19,928 | +2,867 | 0.22 | 0.38 | +0.17 | buy |
| China Universal Asset Management Co., Ltd. | 3,832 | 6,567 | +2,735 | 0.02 | 0.03 | +0.02 | buy |
| Sargent Investment Group, LLC | 11,117 | 8,240 | -2,877 | 0.05 | 0.07 | +0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20,000 | 15,200 | -4,800 | 0.04 | 0.04 | +0.00 | sell |
| Exome Asset Management LLC | 84,400 | 66,300 | -18,100 | 1.69 | 2.06 | +0.37 | sell |
| Cormorant Asset Management, LP | 2,221,422 | 2,139,102 | -82,320 | 2.15 | 3.41 | +1.26 | sell |
| Sands Capital Alternatives, LLC | 260,000 | 170,000 | -90,000 | 1.46 | 1.49 | +0.03 | sell |
| Nantahala Capital Management, LLC | 375,276 | 150,321 | -224,955 | 0.45 | 0.31 | -0.14 | sell |
| TCG Crossover Management, LLC | 1,142,857 | 793,829 | -349,028 | 2.57 | 2.28 | -0.29 | sell |
| TFG Asset Management GP Ltd | 800,000 | 450,000 | -350,000 | 3.90 | 3.71 | -0.20 | sell |
| Vivo Capital, LLC | 1,784,006 | 565,550 | -1,218,456 | 2.96 | 1.62 | -1.34 | sell |