| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rock Springs Capital Management LP | 110,889 | 354,376 | +243,487 | 0.23 | 1.04 | +0.81 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,254,797 | 2,454,797 | +200,000 | 8.26 | 6.98 | -1.28 | buy |
| Cutter Capital Management, LP | 112,500 | 205,000 | +92,500 | 2.55 | 4.59 | +2.03 | buy |
| RTW INVESTMENTS, LP | 3,236,549 | 3,316,032 | +79,483 | 2.71 | 2.61 | -0.10 | buy |
| Paradigm Biocapital Advisors LP | 2,531,896 | 2,610,197 | +78,301 | 4.88 | 6.17 | +1.29 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 82,300 | 7,000 | +75,300 | 0.00 | 0.00 | 0.00 | sell |
| LORD, ABBETT & CO. LLC | 1,279,987 | 1,331,701 | +51,714 | 0.22 | 0.24 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 148,735 | 120,805 | +27,930 | 0.01 | 0.01 | 0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 65,955 | 81,331 | +15,376 | 0.82 | 0.87 | +0.06 | buy |
| GILDER GAGNON HOWE & CO LLC | 404,237 | 416,811 | +12,574 | 0.24 | 0.28 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 181,122 | 168,721 | +12,401 | 0.02 | 0.02 | 0.00 | sell |
| J. Goldman & Co LP | 130,195 | 140,288 | +10,093 | 0.19 | 0.18 | -0.01 | buy |
| E. Ohman J:or Asset Management AB | 34,781 | 42,981 | +8,200 | 0.04 | 0.06 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,504 | 9,802 | +2,298 | 0.07 | 0.08 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 22,113 | 20,768 | +1,345 | 0.05 | 0.05 | 0.00 | sell |
| Bayesian Capital Management, LP | 4,114 | 5,214 | +1,100 | 0.03 | 0.04 | +0.02 | buy |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 4,745 | 5,510 | +765 | 0.02 | 0.02 | +0.00 | buy |
| Quarry LP | 3,000 | 3,599 | +599 | 0.03 | 0.05 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 803 | 978 | +175 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 8,436 | 8,405 | -31 | 0.02 | 0.02 | +0.00 | sell |
| Rafferty Asset Management, LLC | 6,804 | 6,580 | -224 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,106 | 7,698 | -408 | 0.04 | 0.04 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 54,988 | 52,492 | -2,496 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 20,300 | 17,250 | -3,050 | 0.75 | 0.69 | -0.06 | sell |
| ALPS ADVISORS INC | 30,906 | 27,836 | -3,070 | 0.01 | 0.01 | -0.00 | sell |
| Numerai GP LLC | 18,668 | 14,459 | -4,209 | 0.28 | 0.14 | -0.14 | sell |
| JENNISON ASSOCIATES LLC | 2,500,132 | 2,492,640 | -7,492 | 0.08 | 0.09 | +0.01 | sell |
| Woodline Partners LP | 108,986 | 100,149 | -8,837 | 0.04 | 0.03 | -0.01 | sell |
| Legato Capital Management LLC | 45,656 | 31,958 | -13,698 | 0.33 | 0.22 | -0.11 | sell |
| Informed Momentum Co LLC | 71,815 | 52,413 | -19,402 | 0.56 | 0.47 | -0.10 | sell |
| TFG Asset Management GP Ltd | 200,000 | 178,470 | -21,530 | 2.83 | 2.09 | -0.74 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 79,760 | 54,447 | -25,313 | 0.79 | 0.58 | -0.21 | sell |
| Lisanti Capital Growth, LLC | 96,935 | 70,180 | -26,755 | 1.29 | 1.07 | -0.22 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 460,773 | 433,171 | -27,602 | 0.00 | 0.00 | -0.00 | sell |
| Atika Capital Management LLC | 177,200 | 144,400 | -32,800 | 1.04 | 1.04 | +0.00 | sell |
| Aberdeen Group plc | 93,650 | 51,869 | -41,781 | 0.01 | 0.01 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 173,144 | 127,932 | -45,212 | 8.22 | 5.92 | -2.30 | sell |
| Artisan Partners Limited Partnership | 691,299 | 603,214 | -88,085 | 0.06 | 0.05 | -0.01 | sell |
| Cormorant Asset Management, LP | 500,000 | 400,000 | -100,000 | 1.52 | 1.55 | +0.02 | sell |
| Ikarian Capital, LLC | 607,689 | 485,021 | -122,668 | 9.61 | 8.12 | -1.49 | sell |
| Integral Health Asset Management, LLC | 350,000 | 200,000 | -150,000 | 1.71 | 1.14 | -0.58 | sell |
| Frazier Life Sciences Management, L.P. | 1,587,527 | 1,397,527 | -190,000 | 3.65 | 3.28 | -0.37 | sell |