| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 1,484,266 | +1,484,266 | 0.00 | 2.47 | +2.47 | buy |
| CITADEL ADVISORS LLC | 79,341 | 992,642 | +913,301 | 0.00 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 717,853 | +717,853 | 0.00 | 0.36 | +0.36 | buy |
| ORBIMED ADVISORS LLC | 0 | 653,743 | +653,743 | 0.00 | 0.81 | +0.81 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 510,000 | +510,000 | 0.00 | 0.05 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 12,482 | 512,960 | +500,478 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 391,061 | +391,061 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 110,889 | 354,376 | +243,487 | 0.23 | 1.04 | +0.81 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,254,797 | 2,454,797 | +200,000 | 8.26 | 6.98 | -1.28 | buy |
| Qube Research & Technologies Ltd | 97,996 | 246,844 | +148,848 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 2,167 | 134,617 | +132,450 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,115,162 | 2,226,595 | +111,433 | 0.00 | 0.00 | +0.00 | buy |
| Cutter Capital Management, LP | 112,500 | 205,000 | +92,500 | 2.55 | 4.59 | +2.03 | buy |
| BANK OF AMERICA CORP /DE/ | 337,856 | 429,144 | +91,288 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 5,130 | 84,697 | +79,567 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,236,549 | 3,316,032 | +79,483 | 2.71 | 2.61 | -0.10 | buy |
| Paradigm Biocapital Advisors LP | 2,531,896 | 2,610,197 | +78,301 | 4.88 | 6.17 | +1.29 | buy |
| MACQUARIE GROUP LTD | 815,912 | 892,781 | +76,869 | 0.05 | 0.06 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 74,920 | +74,920 | 0.00 | 0.13 | +0.13 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 71,592 | +71,592 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,848 | 75,708 | +70,860 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 59,674 | +59,674 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 1,279,987 | 1,331,701 | +51,714 | 0.22 | 0.24 | +0.02 | buy |
| Squarepoint Ops LLC | 6,004 | 57,656 | +51,652 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 48,800 | +48,800 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 365,544 | 410,676 | +45,132 | 0.02 | 0.03 | +0.00 | buy |
| MORGAN STANLEY | 1,969,071 | 2,012,777 | +43,706 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 4,031 | 44,320 | +40,289 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.18 | +0.18 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 35,393 | +35,393 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 61,307 | 92,687 | +31,380 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 28,173 | +28,173 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 838,804 | 865,434 | +26,630 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 16,020 | +16,020 | 0.00 | 0.03 | +0.03 | buy |
| Waverly Advisors, LLC | 0 | 16,009 | +16,009 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 65,955 | 81,331 | +15,376 | 0.82 | 0.87 | +0.06 | buy |
| GILDER GAGNON HOWE & CO LLC | 404,237 | 416,811 | +12,574 | 0.24 | 0.28 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 47,685 | 58,914 | +11,229 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 9,760 | 20,652 | +10,892 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 130,195 | 140,288 | +10,093 | 0.25 | 0.26 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,777 | 55,837 | +9,060 | 0.00 | 0.00 | +0.00 | buy |
| OmniStar Financial Group, Inc. | 0 | 8,367 | +8,367 | 0.00 | 0.34 | +0.34 | buy |
| CIBC WORLD MARKETS CORP | 0 | 8,260 | +8,260 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 34,781 | 42,981 | +8,200 | 0.04 | 0.06 | +0.01 | buy |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | 7,076 | +7,076 | 0.00 | 1.74 | +1.74 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,025 | +7,025 | 0.00 | 0.10 | +0.10 | buy |
| Engineers Gate Manager LP | 0 | 6,727 | +6,727 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 6,500 | +6,500 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 357,616 | 363,432 | +5,816 | 0.00 | 0.00 | -0.00 | buy |
| Valmark Advisers, Inc. | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 5,284 | +5,284 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,213 | 37,456 | +5,243 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 5,228 | +5,228 | 0.00 | 0.04 | +0.04 | buy |
| Sandia Investment Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.75 | +0.75 | buy |
| AlphaQuest LLC | 0 | 3,672 | +3,672 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 52,333 | 55,533 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 9,800 | 12,701 | +2,901 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 57,004 | 59,843 | +2,839 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,504 | 9,802 | +2,298 | 0.07 | 0.08 | +0.01 | buy |
| RHUMBLINE ADVISERS | 49,534 | 51,682 | +2,148 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 3,161 | 5,223 | +2,062 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,468 | 8,025 | +1,557 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,826 | 71,220 | +1,394 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,926 | 22,143 | +1,217 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 13,177 | 14,303 | +1,126 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 4,114 | 5,214 | +1,100 | 0.03 | 0.04 | +0.02 | buy |
| Legal & General Group Plc | 26,595 | 27,594 | +999 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 38,250 | 39,054 | +804 | 0.00 | 0.00 | +0.00 | buy |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 4,745 | 5,510 | +765 | 0.02 | 0.02 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 504 | 1,263 | +759 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,681 | 15,391 | +710 | 0.01 | 0.01 | +0.00 | buy |
| Quarry LP | 3,000 | 3,599 | +599 | 0.03 | 0.05 | +0.01 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 579 | +579 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 571 | +571 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 7,712 | 8,182 | +470 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 5,200 | 5,600 | +400 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 19,999 | 20,367 | +368 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 149 | 457 | +308 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 979 | 1,274 | +295 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 143 | 373 | +230 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 36 | 256 | +220 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 130,097 | 130,289 | +192 | 0.08 | 0.08 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 184 | +184 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 803 | 978 | +175 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 4,934 | 5,088 | +154 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 56 | 118 | +62 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 41 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 107 | 137 | +30 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 173 | 196 | +23 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 50 | 70 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,274 | 1,284 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Stephens Consulting, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 7 | 14 | +7 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 285 | 285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,848 | 3,848 | 0 | 0.01 | 0.01 | -0.00 | hold |