| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 3,004,034 | 3,600,000 | +595,966 | 5.61 | 5.21 | -0.40 | buy |
| BlackRock, Inc. | 3,790,557 | 3,552,612 | -237,945 | 0.01 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 3,335,320 | 3,346,025 | +10,705 | 2.74 | 2.34 | -0.40 | buy |
| Paradigm Biocapital Advisors LP | 2,562,154 | 2,562,154 | 0 | 5.62 | 3.67 | -1.94 | hold |
| JANUS HENDERSON GROUP PLC | 1,930,325 | 2,240,963 | +310,638 | 0.07 | 0.08 | +0.00 | buy |
| MORGAN STANLEY | 2,040,742 | 1,944,272 | -96,470 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 2,230,069 | 1,712,124 | -517,945 | 0.11 | 0.08 | -0.03 | sell |
| Assenagon Asset Management S.A. | 1,127,730 | 1,280,194 | +152,464 | 0.14 | 0.14 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 758,106 | 1,194,377 | +436,271 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | 1,188,624 | 0 | 4.81 | 4.23 | -0.57 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 947,763 | 1,121,091 | +173,328 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 929,059 | 978,212 | +49,153 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,172,427 | 926,125 | -246,302 | 0.65 | 0.48 | -0.17 | sell |
| LORD, ABBETT & CO. LLC | 855,645 | 842,313 | -13,332 | 0.21 | 0.19 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 615,156 | 791,146 | +175,990 | 0.04 | 0.04 | +0.01 | buy |
| Invesco Ltd. | 1,012,357 | 742,497 | -269,860 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 647,114 | 733,334 | +86,220 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 728,644 | 728,644 | 0 | 1.60 | 1.32 | -0.29 | hold |
| MILLENNIUM MANAGEMENT LLC | 117,004 | 564,579 | +447,575 | 0.01 | 0.03 | +0.02 | buy |
| Clearbridge Investments, LLC | 506,089 | 545,351 | +39,262 | 0.03 | 0.03 | +0.00 | buy |
| TORONTO DOMINION BANK | 510,253 | 510,253 | 0 | 0.07 | 0.07 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 378,704 | 439,626 | +60,922 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 441,873 | 407,836 | -34,037 | 0.04 | 0.04 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 332,446 | 388,590 | +56,144 | 0.41 | 0.46 | +0.05 | buy |
| NORTHERN TRUST CORP | 342,486 | 352,957 | +10,471 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 337,016 | 333,676 | -3,340 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 474,050 | 332,982 | -141,068 | 0.07 | 0.04 | -0.03 | sell |
| MPM BioImpact LLC | 328,869 | 329,750 | +881 | 3.08 | 1.79 | -1.29 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333,111 | 328,162 | -4,949 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 401,241 | 324,014 | -77,227 | 0.05 | 0.03 | -0.01 | sell |
| Nuveen, LLC | 322,527 | 315,290 | -7,237 | 0.01 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 436,576 | 307,307 | -129,269 | 0.05 | 0.04 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 356,105 | 303,509 | -52,596 | 0.02 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 518,780 | 274,804 | -243,976 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 0 | 265,715 | +265,715 | 0.00 | 0.62 | +0.62 | buy |
| Tri Locum Partners LP | 0 | 252,588 | +252,588 | 0.00 | 2.49 | +2.49 | buy |
| Squarepoint Ops LLC | 21,833 | 241,033 | +219,200 | 0.00 | 0.04 | +0.03 | buy |
| Point72 Asset Management, L.P. | 37,628 | 226,251 | +188,623 | 0.00 | 0.03 | +0.02 | buy |
| Rock Springs Capital Management LP | 260,344 | 225,179 | -35,165 | 1.09 | 0.93 | -0.16 | sell |
| Cormorant Asset Management, LP | 250,000 | 225,000 | -25,000 | 1.16 | 0.80 | -0.36 | sell |
| Integral Health Asset Management, LLC | 200,000 | 200,000 | 0 | 0.83 | 0.74 | -0.09 | hold |
| Vestal Point Capital, LP | 0 | 200,000 | +200,000 | 0.00 | 0.39 | +0.39 | buy |
| M&G Plc | 0 | 166,364 | +166,364 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 0 | 163,997 | +163,997 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 151,100 | 152,200 | +1,100 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 153,760 | 145,926 | -7,834 | 0.01 | 0.01 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 130,380 | 131,612 | +1,232 | 0.02 | 0.02 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 111,770 | 122,911 | +11,141 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 118,229 | 121,862 | +3,633 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 118,810 | 118,810 | 0 | 0.08 | 0.10 | +0.02 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 173,275 | 111,437 | -61,838 | 0.04 | 0.02 | -0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 161,830 | 108,800 | -53,030 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 107,760 | 106,782 | -978 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 100,154 | 100,443 | +289 | 0.03 | 0.03 | -0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,857 | 90,663 | -19,194 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 119,058 | 89,293 | -29,765 | 0.00 | 0.00 | -0.00 | sell |
| Sands Capital Alternatives, LLC | 85,000 | 85,000 | 0 | 1.34 | 1.42 | +0.07 | hold |
| UBS Group AG | 66,899 | 82,124 | +15,225 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 68,295 | 80,892 | +12,597 | 0.01 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 80,859 | +80,859 | 0.00 | 5.64 | +5.64 | buy |
| PFM Health Sciences, LP | 27,338 | 80,226 | +52,888 | 0.23 | 0.59 | +0.37 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 64,100 | 73,400 | +9,300 | 0.01 | 0.01 | -0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 114,460 | 71,135 | -43,325 | 0.10 | 0.06 | -0.04 | sell |
| Voleon Capital Management LP | 77,375 | 68,935 | -8,440 | 0.14 | 0.10 | -0.03 | sell |
| Cinctive Capital Management LP | 28,838 | 68,769 | +39,931 | 0.14 | 0.32 | +0.18 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,912 | 67,087 | +35,175 | 0.01 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 63,026 | 63,026 | 0 | 0.33 | 0.26 | -0.07 | hold |
| Swiss National Bank | 62,433 | 62,933 | +500 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,335 | 62,706 | -3,629 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 51,971 | 54,335 | +2,364 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 53,564 | 52,464 | -1,100 | 1.13 | 1.02 | -0.11 | sell |
| XTX Topco Ltd | 18,410 | 51,634 | +33,224 | 0.04 | 0.06 | +0.02 | buy |
| FEDERATED HERMES, INC. | 49,289 | 49,094 | -195 | 0.01 | 0.01 | -0.00 | sell |
| Jump Financial, LLC | 128,087 | 47,600 | -80,487 | 0.13 | 0.05 | -0.08 | sell |
| RHUMBLINE ADVISERS | 47,080 | 46,958 | -122 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 34,442 | 43,832 | +9,390 | 0.01 | 0.01 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 33,323 | 42,087 | +8,764 | 0.06 | 0.08 | +0.01 | buy |
| Baird Financial Group, Inc. | 46,928 | 41,977 | -4,951 | 0.01 | 0.00 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 64,341 | 41,815 | -22,526 | 1.25 | 0.74 | -0.51 | sell |
| ALLIANCEBERNSTEIN L.P. | 40,654 | 40,616 | -38 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 37,578 | 38,198 | +620 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,179 | 37,695 | +7,516 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,283 | 37,404 | -17,879 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 36,448 | +36,448 | 0.00 | 0.12 | +0.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,155 | 35,918 | -7,237 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 35,649 | 34,784 | -865 | 0.00 | 0.00 | -0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 34,685 | +34,685 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 34,755 | 34,647 | -108 | 0.02 | 0.01 | -0.01 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 50,000 | 32,000 | -18,000 | 0.01 | 0.01 | -0.01 | sell |
| ALGERT GLOBAL LLC | 45,985 | 31,760 | -14,225 | 0.06 | 0.03 | -0.03 | sell |
| Ikarian Capital, LLC | 31,166 | 31,166 | 0 | 0.33 | 0.31 | -0.02 | hold |
| SEI INVESTMENTS CO | 43,344 | 31,075 | -12,269 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 56,646 | 30,478 | -26,168 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,919 | 30,453 | +4,534 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 51,487 | 30,320 | -21,167 | 0.05 | 0.02 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 64,012 | 30,012 | -34,000 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 21,722 | 29,283 | +7,561 | 0.14 | 0.17 | +0.03 | buy |
| BARCLAYS PLC | 80,784 | 28,004 | -52,780 | 0.00 | 0.00 | -0.00 | sell |
| Capricorn Fund Managers Ltd | 21,982 | 26,000 | +4,018 | 0.43 | 0.28 | -0.15 | buy |
| DIADEMA PARTNERS LP | 0 | 25,942 | +25,942 | 0.00 | 0.75 | +0.75 | buy |