| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Assenagon Asset Management S.A. | 0 | 1,063,422 | +1,063,422 | 0.00 | 0.07 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 215,958 | 670,459 | +454,501 | 0.10 | 0.20 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 82,226 | 463,240 | +381,014 | 0.01 | 0.04 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 25,644 | 348,586 | +322,942 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 150,000 | 454,991 | +304,991 | 0.01 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 147,826 | 434,342 | +286,516 | 0.01 | 0.03 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 73,900 | 307,600 | +233,700 | 0.01 | 0.02 | +0.01 | buy |
| J. Goldman & Co LP | 163,347 | 387,161 | +223,814 | 0.27 | 0.39 | +0.12 | buy |
| STATE STREET CORP | 717,090 | 925,639 | +208,549 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 161,163 | 364,463 | +203,300 | 0.06 | 0.10 | +0.04 | buy |
| Qube Research & Technologies Ltd | 33,363 | 226,879 | +193,516 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 223,569 | 391,563 | +167,994 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,826,632 | 1,989,693 | +163,061 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 270,758 | 420,758 | +150,000 | 0.20 | 0.22 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 1,330,938 | 1,479,868 | +148,930 | 0.03 | 0.03 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 629,692 | 773,235 | +143,543 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 3,272,341 | 3,412,486 | +140,145 | 1.76 | 1.44 | -0.32 | buy |
| Ikarian Capital, LLC | 710,277 | 800,277 | +90,000 | 7.02 | 6.79 | -0.23 | buy |
| Hudson Bay Capital Management LP | 0 | 85,000 | +85,000 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 79,515 | +79,515 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 196,512 | 269,793 | +73,281 | 0.01 | 0.01 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 54,152 | +54,152 | 0.00 | 0.03 | +0.03 | buy |
| TFG Asset Management GP Ltd | 450,000 | 500,000 | +50,000 | 4.50 | 4.21 | -0.28 | buy |
| Russell Investments Group, Ltd. | 30,036 | 75,876 | +45,840 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 38,275 | 78,847 | +40,572 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.27 | +0.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,997 | 261,879 | +39,882 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 38,301 | +38,301 | 0.00 | 0.04 | +0.04 | buy |
| Advisory Services Network, LLC | 0 | 37,811 | +37,811 | 0.00 | 0.02 | +0.02 | buy |
| Aberdeen Group plc | 72,032 | 102,555 | +30,523 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 22,720 | 53,126 | +30,406 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 27,827 | +27,827 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 96,409 | 122,634 | +26,225 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 175,512 | 200,094 | +24,582 | 0.18 | 0.16 | -0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,838 | 47,065 | +24,227 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,422 | 127,328 | +15,906 | 0.00 | 0.00 | -0.00 | buy |
| E. Ohman J:or Asset Management AB | 25,000 | 38,981 | +13,981 | 0.02 | 0.03 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 13,761 | +13,761 | 0.00 | 0.07 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 229,492 | 243,112 | +13,620 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 15,531 | 28,137 | +12,606 | 0.00 | 0.01 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 12,295 | +12,295 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 11,347 | +11,347 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 11,131 | +11,131 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 15,465 | 26,483 | +11,018 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 10,619 | +10,619 | 0.00 | 0.06 | +0.06 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 10,034 | +10,034 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 9,067 | +9,067 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,300 | 35,120 | +7,820 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 7,481 | +7,481 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,450 | +7,450 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 7,429 | +7,429 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 43,590 | 49,660 | +6,070 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 15,540 | 21,504 | +5,964 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 247,177 | 253,016 | +5,839 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 342 | 5,844 | +5,502 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 42,433 | 47,333 | +4,900 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 11,519 | 15,990 | +4,471 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 4,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,170 | 33,282 | +3,112 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 26,448 | 29,468 | +3,020 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 3,270 | 6,245 | +2,975 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 9,554 | 12,321 | +2,767 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 2,255 | +2,255 | 0.00 | 0.01 | +0.01 | buy |
| Janney Montgomery Scott LLC | 20,901 | 23,068 | +2,167 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,281 | 24,411 | +2,130 | 0.00 | 0.00 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 5,729 | 7,669 | +1,940 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 7,197 | 9,126 | +1,929 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 203,730 | 205,551 | +1,821 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 22,831 | 24,486 | +1,655 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 14,122 | 15,750 | +1,628 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,874 | 13,483 | +1,609 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,579 | 6,109 | +1,530 | 0.00 | 0.00 | -0.00 | buy |
| Alpha DNA Investment Management LLC | 13,913 | 15,174 | +1,261 | 0.28 | 0.23 | -0.04 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,128 | +1,128 | 0.00 | 0.00 | +0.00 | buy |
| Coppell Advisory Solutions LLC | 0 | 682 | +682 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,970 | 3,604 | +634 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 627,430 | 627,578 | +148 | 0.03 | 0.03 | -0.01 | buy |
| Spire Wealth Management | 133 | 260 | +127 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 224 | 283 | +59 | 0.01 | 0.01 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2 | 37 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 41 | 65 | +24 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,479 | 39,499 | +20 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 132 | 140 | +8 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 10 | +5 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 1,296,416 | 0 | 0.83 | 0.85 | +0.02 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,254,797 | 2,254,797 | 0 | 8.53 | 6.24 | -2.29 | hold |
| Daiwa Securities Group Inc. | 107 | 107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Riggs Asset Managment Co. Inc. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Venturi Wealth Management, LLC | 861 | 861 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 565,550 | 565,550 | 0 | 1.62 | 1.42 | -0.20 | hold |
| Integral Health Asset Management, LLC | 590,000 | 590,000 | 0 | 2.11 | 1.60 | -0.51 | hold |
| Sands Capital Alternatives, LLC | 170,000 | 170,000 | 0 | 1.49 | 1.55 | +0.06 | hold |
| Covestor Ltd | 3 | 3 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Farther Finance Advisors, LLC | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 979 | 979 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |