| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ExodusPoint Capital Management, LP | 215,958 | 670,459 | +454,501 | 0.10 | 0.20 | 0.00 | buy |
| LORD, ABBETT & CO. LLC | 82,226 | 463,240 | +381,014 | 0.01 | 0.04 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 147,826 | 434,342 | +286,516 | 0.01 | 0.03 | 0.00 | buy |
| J. Goldman & Co LP | 163,347 | 387,161 | +223,814 | 0.19 | 0.30 | +0.11 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 161,163 | 364,463 | +203,300 | 0.06 | 0.10 | +0.04 | buy |
| JENNISON ASSOCIATES LLC | 1,330,938 | 1,479,868 | +148,930 | 0.03 | 0.03 | -0.01 | buy |
| RTW INVESTMENTS, LP | 3,272,341 | 3,412,486 | +140,145 | 1.76 | 1.44 | -0.32 | buy |
| Ikarian Capital, LLC | 710,277 | 800,277 | +90,000 | 7.02 | 6.79 | -0.23 | buy |
| TFG Asset Management GP Ltd | 450,000 | 500,000 | +50,000 | 3.71 | 3.39 | -0.32 | buy |
| Aberdeen Group plc | 72,032 | 102,555 | +30,523 | 0.01 | 0.01 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 25,000 | 38,981 | +13,981 | 0.02 | 0.03 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 97,047 | 85,323 | +11,724 | 0.02 | 0.01 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 192,303 | 181,066 | +11,237 | 0.01 | 0.01 | 0.00 | sell |
| ALPS ADVISORS INC | 26,448 | 29,468 | +3,020 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 7,197 | 9,126 | +1,929 | 0.01 | 0.01 | 0.00 | buy |
| Alpha DNA Investment Management LLC | 13,913 | 15,174 | +1,261 | 0.28 | 0.23 | -0.04 | buy |
| Artisan Partners Limited Partnership | 627,430 | 627,578 | +148 | 0.03 | 0.03 | -0.01 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 224 | 283 | +59 | 0.01 | 0.01 | -0.00 | buy |
| Jackson Creek Investment Advisors LLC | 29,577 | 29,524 | -53 | 0.38 | 0.29 | -0.09 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 11,620 | 11,493 | -127 | 0.06 | 0.02 | -0.03 | sell |
| Sargent Investment Group, LLC | 8,240 | 8,093 | -147 | 0.07 | 0.04 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 6,567 | 4,438 | -2,129 | 0.03 | 0.02 | -0.01 | sell |
| Calamos Advisors LLC | 9,878 | 7,404 | -2,474 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 19,928 | 9,938 | -9,990 | 0.38 | 0.13 | -0.25 | sell |
| Frazier Life Sciences Management, L.P. | 1,787,527 | 1,587,527 | -200,000 | 2.74 | 2.02 | -0.72 | sell |
| TCG Crossover Management, LLC | 793,829 | 556,317 | -237,512 | 2.28 | 1.58 | -0.71 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 609,104 | 216,047 | -393,057 | 4.48 | 1.53 | -2.95 | sell |
| Paradigm Biocapital Advisors LP | 2,863,406 | 2,435,416 | -427,990 | 3.66 | 2.53 | -1.13 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 898,000 | 389,600 | -508,400 | 0.11 | 0.03 | -0.08 | sell |
| Cormorant Asset Management, LP | 2,139,102 | 500,000 | -1,639,102 | 3.41 | 0.79 | -2.63 | sell |