| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 512,960 | 1,806,947 | +1,293,987 | 0.01 | 0.04 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,610,197 | 2,976,099 | +365,902 | 6.17 | 5.15 | -1.02 | buy |
| D. E. Shaw & Co., Inc. | 410,676 | 723,183 | +312,507 | 0.03 | 0.03 | 0.00 | buy |
| Deep Track Capital, LP | 1,484,266 | 1,750,000 | +265,734 | 2.47 | 2.28 | -0.19 | buy |
| J. Goldman & Co LP | 140,288 | 364,557 | +224,269 | 0.18 | 0.35 | +0.18 | buy |
| Qube Research & Technologies Ltd | 246,844 | 459,436 | +212,592 | 0.02 | 0.03 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 717,853 | 876,547 | +158,694 | 0.36 | 0.28 | -0.07 | buy |
| TFG Asset Management GP Ltd | 178,470 | 250,000 | +71,530 | 2.09 | 1.63 | -0.46 | buy |
| PRUDENTIAL FINANCIAL INC | 120,805 | 182,400 | +61,595 | 0.01 | 0.01 | 0.00 | buy |
| Allspring Global Investments Holdings, LLC | 168,721 | 132,562 | +36,159 | 0.02 | 0.01 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 510,000 | 543,000 | +33,000 | 0.05 | 0.04 | -0.01 | buy |
| Rock Springs Capital Management LP | 354,376 | 373,750 | +19,374 | 1.04 | 0.94 | -0.10 | buy |
| Aberdeen Group plc | 51,869 | 61,597 | +9,728 | 0.01 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 5,228 | 11,905 | +6,677 | 0.04 | 0.05 | +0.02 | buy |
| Lisanti Capital Growth, LLC | 70,180 | 75,525 | +5,345 | 1.07 | 0.85 | -0.22 | buy |
| ALPS ADVISORS INC | 27,836 | 22,678 | +5,158 | 0.01 | 0.01 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 7,025 | 10,852 | +3,827 | 0.10 | 0.15 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 20,768 | 24,267 | +3,499 | 0.05 | 0.04 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 17,250 | 18,535 | +1,285 | 0.69 | 0.50 | -0.19 | buy |
| PROFUND ADVISORS LLC | 8,405 | 9,469 | +1,064 | 0.02 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,698 | 8,438 | +740 | 0.04 | 0.03 | -0.00 | buy |
| Quarry LP | 3,599 | 3,000 | +599 | 0.05 | 0.03 | 0.00 | sell |
| Optiver Holding B.V. | 184 | 272 | +88 | 0.00 | 0.00 | 0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 12,383 | 12,407 | +24 | 0.00 | 0.00 | -0.00 | buy |
| E. Ohman J:or Asset Management AB | 42,981 | 41,023 | -1,958 | 0.06 | 0.04 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 127,932 | 121,182 | -6,750 | 5.92 | 4.08 | -1.84 | sell |
| TD ASSET MANAGEMENT INC | 52,492 | 43,292 | -9,200 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 31,958 | 15,205 | -16,753 | 0.22 | 0.07 | -0.15 | sell |
| JENNISON ASSOCIATES LLC | 2,492,640 | 2,467,998 | -24,642 | 0.09 | 0.06 | -0.03 | sell |
| Artisan Partners Limited Partnership | 603,214 | 539,303 | -63,911 | 0.05 | 0.03 | -0.02 | sell |
| Cormorant Asset Management, LP | 400,000 | 300,000 | -100,000 | 1.55 | 0.91 | -0.64 | sell |
| RTW INVESTMENTS, LP | 3,316,032 | 3,111,680 | -204,352 | 2.61 | 1.80 | -0.81 | sell |
| Ikarian Capital, LLC | 485,021 | 196,536 | -288,485 | 8.12 | 2.63 | -5.48 | sell |
| LORD, ABBETT & CO. LLC | 1,331,701 | 995,425 | -336,276 | 0.24 | 0.13 | -0.11 | sell |
| GILDER GAGNON HOWE & CO LLC | 416,811 | 77,164 | -339,647 | 0.28 | 0.03 | -0.25 | sell |
| ORBIMED ADVISORS LLC | 653,743 | 197,900 | -455,843 | 0.81 | 0.20 | -0.60 | sell |