| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 512,960 | 1,806,947 | +1,293,987 | 0.01 | 0.04 | +0.02 | buy |
| BlackRock, Inc. | 3,153,728 | 3,792,185 | +638,457 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 0 | 444,502 | +444,502 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 2,610,197 | 2,976,099 | +365,902 | 6.17 | 5.15 | -1.02 | buy |
| MPM BioImpact LLC | 0 | 341,496 | +341,496 | 0.00 | 2.40 | +2.40 | buy |
| D. E. Shaw & Co., Inc. | 410,676 | 723,183 | +312,507 | 0.03 | 0.03 | +0.00 | buy |
| Deep Track Capital, LP | 1,484,266 | 1,750,000 | +265,734 | 2.47 | 2.28 | -0.19 | buy |
| J. Goldman & Co LP | 140,288 | 364,557 | +224,269 | 0.26 | 0.46 | +0.21 | buy |
| Qube Research & Technologies Ltd | 246,844 | 459,436 | +212,592 | 0.02 | 0.03 | +0.01 | buy |
| Jump Financial, LLC | 48,800 | 237,117 | +188,317 | 0.04 | 0.12 | +0.08 | buy |
| ROYAL BANK OF CANADA | 3,080 | 189,551 | +186,471 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 177,656 | +177,656 | 0.00 | 2.18 | +2.18 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 717,853 | 876,547 | +158,694 | 0.36 | 0.28 | -0.07 | buy |
| JPMORGAN CHASE & CO | 27,973 | 140,610 | +112,637 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 105,090 | +105,090 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 826,523 | 928,501 | +101,978 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 301,510 | 397,994 | +96,484 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 94,624 | +94,624 | 0.00 | 0.04 | +0.04 | buy |
| Jefferies Financial Group Inc. | 78,808 | 162,996 | +84,188 | 0.07 | 0.11 | +0.04 | buy |
| NORGES BANK | 391,061 | 471,354 | +80,293 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 59,674 | 138,019 | +78,345 | 0.01 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 75,708 | 152,309 | +76,601 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 52,839 | 127,579 | +74,740 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 264,523 | 336,939 | +72,416 | 0.00 | 0.00 | -0.00 | buy |
| TFG Asset Management GP Ltd | 178,470 | 250,000 | +71,530 | 2.94 | 1.83 | -1.11 | buy |
| VANGUARD GROUP INC | 2,226,595 | 2,297,354 | +70,759 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 910,716 | 980,868 | +70,152 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 865,434 | 934,420 | +68,986 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,843 | 126,953 | +67,110 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 63,026 | +63,026 | 0.00 | 0.14 | +0.14 | buy |
| PRUDENTIAL FINANCIAL INC | 120,805 | 182,400 | +61,595 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 60,495 | +60,495 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 58,613 | +58,613 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 892,781 | 948,850 | +56,069 | 0.06 | 0.05 | -0.01 | buy |
| Squarepoint Ops LLC | 57,656 | 102,642 | +44,986 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 2,012,777 | 2,055,718 | +42,941 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,318 | 329,297 | +38,979 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 16,224 | 53,568 | +37,344 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 429,144 | 466,280 | +37,136 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 36,354 | +36,354 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 510,000 | 543,000 | +33,000 | 0.05 | 0.04 | -0.01 | buy |
| SG Americas Securities, LLC | 5,223 | 34,012 | +28,789 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 27,094 | +27,094 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,367 | 44,715 | +24,348 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 16,020 | 40,339 | +24,319 | 0.03 | 0.04 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 23,533 | +23,533 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 21,628 | +21,628 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 12,701 | 32,411 | +19,710 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 354,376 | 373,750 | +19,374 | 1.04 | 0.94 | -0.10 | buy |
| Graham Capital Management, L.P. | 6,500 | 24,774 | +18,274 | 0.01 | 0.03 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,320 | 62,235 | +17,915 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 3,672 | 20,636 | +16,964 | 0.02 | 0.08 | +0.06 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 35,393 | 51,752 | +16,359 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 71,220 | 86,378 | +15,158 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 0 | 14,721 | +14,721 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 14,500 | +14,500 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 5,600 | 18,500 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| AlphaCore Capital LLC | 0 | 12,100 | +12,100 | 0.00 | 0.02 | +0.02 | buy |
| HighVista Strategies LLC | 0 | 11,680 | +11,680 | 0.00 | 0.17 | +0.17 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 11,052 | +11,052 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| Bridgefront Capital, LLC | 0 | 10,729 | +10,729 | 0.00 | 0.12 | +0.12 | buy |
| Russell Investments Group, Ltd. | 134,617 | 145,240 | +10,623 | 0.01 | 0.01 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 10,273 | +10,273 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 0 | 9,918 | +9,918 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 51,869 | 61,597 | +9,728 | 0.01 | 0.00 | -0.00 | buy |
| Versor Investments LP | 0 | 9,492 | +9,492 | 0.00 | 0.07 | +0.07 | buy |
| Atom Investors LP | 0 | 8,788 | +8,788 | 0.00 | 0.03 | +0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 71,592 | 79,851 | +8,259 | 0.01 | 0.00 | -0.00 | buy |
| Swiss National Bank | 55,533 | 63,533 | +8,000 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 27,594 | 35,426 | +7,832 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 7,640 | +7,640 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 116,110 | 123,636 | +7,526 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 28,920 | 36,127 | +7,207 | 0.00 | 0.00 | -0.00 | buy |
| Petrus Trust Company, LTA | 0 | 7,061 | +7,061 | 0.00 | 0.03 | +0.03 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 5,228 | 11,905 | +6,677 | 0.04 | 0.05 | +0.02 | buy |
| LPL Financial LLC | 8,025 | 14,341 | +6,316 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 6,727 | 12,815 | +6,088 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 51,682 | 57,650 | +5,968 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 101,013 | 106,792 | +5,779 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 5,612 | +5,612 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 5,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 70,180 | 75,525 | +5,345 | 1.07 | 0.85 | -0.22 | buy |
| Virtus Investment Advisers, LLC | 7,025 | 10,852 | +3,827 | 0.10 | 0.15 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 20,768 | 24,267 | +3,499 | 0.05 | 0.04 | -0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,263 | 4,045 | +2,782 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 2,778 | +2,778 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 130,289 | 132,978 | +2,689 | 0.08 | 0.06 | -0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,391 | 17,309 | +1,918 | 0.01 | 0.01 | -0.00 | buy |
| 1620 INVESTMENT ADVISORS, INC. | 0 | 1,835 | +1,835 | 0.00 | 0.05 | +0.05 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 7,000 | 8,500 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 5,400 | 6,900 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 8,182 | 9,679 | +1,497 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 8,938 | 10,356 | +1,418 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 17,250 | 18,535 | +1,285 | 0.69 | 0.50 | -0.19 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,691 | 8,928 | +1,237 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 8,405 | 9,469 | +1,064 | 0.02 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,819 | 5,755 | +936 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 18,935 | 19,850 | +915 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 22,305 | 23,095 | +790 | 0.01 | 0.01 | -0.00 | buy |