| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,153,728 | 3,792,185 | +638,457 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 3,316,032 | 3,111,680 | -204,352 | 2.61 | 1.80 | -0.81 | sell |
| Paradigm Biocapital Advisors LP | 2,610,197 | 2,976,099 | +365,902 | 6.17 | 5.15 | -1.02 | buy |
| JENNISON ASSOCIATES LLC | 2,492,640 | 2,467,998 | -24,642 | 0.09 | 0.06 | -0.03 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,454,797 | 2,454,797 | 0 | 6.98 | 5.03 | -1.95 | hold |
| VANGUARD GROUP INC | 2,226,595 | 2,297,354 | +70,759 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 2,012,777 | 2,055,718 | +42,941 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 512,960 | 1,806,947 | +1,293,987 | 0.01 | 0.04 | +0.02 | buy |
| Deep Track Capital, LP | 1,484,266 | 1,750,000 | +265,734 | 2.47 | 2.28 | -0.19 | buy |
| Frazier Life Sciences Management, L.P. | 1,397,527 | 1,397,527 | 0 | 3.28 | 2.26 | -1.02 | hold |
| TORONTO DOMINION BANK | 1,874,745 | 1,001,962 | -872,783 | 0.25 | 0.09 | -0.16 | sell |
| Assenagon Asset Management S.A. | 1,125,305 | 997,587 | -127,718 | 0.10 | 0.06 | -0.04 | sell |
| LORD, ABBETT & CO. LLC | 1,331,701 | 995,425 | -336,276 | 0.24 | 0.13 | -0.11 | sell |
| STATE STREET CORP | 910,716 | 980,868 | +70,152 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 892,781 | 948,850 | +56,069 | 0.06 | 0.05 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 865,434 | 934,420 | +68,986 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 826,523 | 928,501 | +101,978 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 717,853 | 876,547 | +158,694 | 0.36 | 0.28 | -0.07 | buy |
| D. E. Shaw & Co., Inc. | 410,676 | 723,183 | +312,507 | 0.03 | 0.03 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 510,000 | 543,000 | +33,000 | 0.05 | 0.04 | -0.01 | buy |
| Artisan Partners Limited Partnership | 603,214 | 539,303 | -63,911 | 0.05 | 0.03 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 487,310 | 487,310 | 0 | 0.05 | 0.03 | -0.01 | hold |
| NORGES BANK | 391,061 | 471,354 | +80,293 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 429,144 | 466,280 | +37,136 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 246,844 | 459,436 | +212,592 | 0.02 | 0.03 | +0.01 | buy |
| Clearbridge Investments, LLC | 0 | 444,502 | +444,502 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 301,510 | 397,994 | +96,484 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 433,171 | 383,902 | -49,269 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 354,376 | 373,750 | +19,374 | 1.04 | 0.94 | -0.10 | buy |
| J. Goldman & Co LP | 140,288 | 364,557 | +224,269 | 0.26 | 0.46 | +0.21 | buy |
| NORTHERN TRUST CORP | 363,432 | 357,178 | -6,254 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 0 | 341,496 | +341,496 | 0.00 | 2.40 | +2.40 | buy |
| Nuveen, LLC | 264,523 | 336,939 | +72,416 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,318 | 329,297 | +38,979 | 0.00 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 400,000 | 300,000 | -100,000 | 1.56 | 0.91 | -0.65 | sell |
| TFG Asset Management GP Ltd | 178,470 | 250,000 | +71,530 | 2.94 | 1.83 | -1.11 | buy |
| Jump Financial, LLC | 48,800 | 237,117 | +188,317 | 0.04 | 0.12 | +0.08 | buy |
| CITADEL ADVISORS LLC | 992,642 | 229,246 | -763,396 | 0.05 | 0.01 | -0.04 | sell |
| Integral Health Asset Management, LLC | 200,000 | 200,000 | 0 | 1.14 | 0.76 | -0.38 | hold |
| ORBIMED ADVISORS LLC | 653,743 | 197,900 | -455,843 | 0.81 | 0.20 | -0.60 | sell |
| Ikarian Capital, LLC | 485,021 | 196,536 | -288,485 | 8.12 | 2.63 | -5.48 | sell |
| ROYAL BANK OF CANADA | 3,080 | 189,551 | +186,471 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 120,805 | 182,400 | +61,595 | 0.01 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 177,656 | +177,656 | 0.00 | 2.18 | +2.18 | buy |
| Sands Capital Alternatives, LLC | 170,000 | 170,000 | 0 | 2.14 | 1.36 | -0.78 | hold |
| Jefferies Financial Group Inc. | 78,808 | 162,996 | +84,188 | 0.07 | 0.11 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 75,708 | 152,309 | +76,601 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 134,617 | 145,240 | +10,623 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 27,973 | 140,610 | +112,637 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 59,674 | 138,019 | +78,345 | 0.01 | 0.01 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 130,289 | 132,978 | +2,689 | 0.08 | 0.06 | -0.02 | buy |
| Allspring Global Investments Holdings, LLC | 168,721 | 132,562 | -36,159 | 0.02 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 52,839 | 127,579 | +74,740 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,843 | 126,953 | +67,110 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 116,110 | 123,636 | +7,526 | 0.00 | 0.00 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 127,932 | 121,182 | -6,750 | 5.92 | 4.08 | -1.84 | sell |
| Bank of New York Mellon Corp | 101,013 | 106,792 | +5,779 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 105,090 | +105,090 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 57,656 | 102,642 | +44,986 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 151,421 | 102,369 | -49,052 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 100,149 | 100,149 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Trexquant Investment LP | 0 | 94,624 | +94,624 | 0.00 | 0.04 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 308,230 | 92,134 | -216,096 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 71,220 | 86,378 | +15,158 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 84,697 | 80,220 | -4,477 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 71,592 | 79,851 | +8,259 | 0.01 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 416,811 | 77,164 | -339,647 | 0.28 | 0.03 | -0.25 | sell |
| Lisanti Capital Growth, LLC | 70,180 | 75,525 | +5,345 | 1.07 | 0.85 | -0.22 | buy |
| Swiss National Bank | 55,533 | 63,533 | +8,000 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 63,026 | +63,026 | 0.00 | 0.14 | +0.14 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,320 | 62,235 | +17,915 | 0.00 | 0.00 | -0.00 | buy |
| Baird Financial Group, Inc. | 110,792 | 61,681 | -49,111 | 0.01 | 0.00 | -0.01 | sell |
| Aberdeen Group plc | 51,869 | 61,597 | +9,728 | 0.01 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 60,495 | +60,495 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 58,613 | +58,613 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 247,195 | 58,141 | -189,054 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 51,682 | 57,650 | +5,968 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 54,682 | 55,021 | +339 | 0.01 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 16,224 | 53,568 | +37,344 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,837 | 53,028 | -2,809 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,857 | 52,334 | -8,523 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 35,393 | 51,752 | +16,359 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,367 | 44,715 | +24,348 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 52,492 | 43,292 | -9,200 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,004 | 43,004 | 0 | 0.00 | 0.00 | -0.00 | hold |
| E. Ohman J:or Asset Management AB | 42,981 | 41,023 | -1,958 | 0.06 | 0.04 | -0.02 | sell |
| Quantbot Technologies LP | 16,020 | 40,339 | +24,319 | 0.03 | 0.04 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,054 | 39,054 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aquatic Capital Management LLC | 0 | 36,354 | +36,354 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 28,920 | 36,127 | +7,207 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 27,594 | 35,426 | +7,832 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 5,223 | 34,012 | +28,789 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 12,701 | 32,411 | +19,710 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 37,371 | 30,058 | -7,313 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 121,273 | 29,848 | -91,425 | 0.21 | 0.04 | -0.18 | sell |
| UBS Group AG | 92,687 | 28,506 | -64,181 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 27,094 | +27,094 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,364 | 25,364 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 6,500 | 24,774 | +18,274 | 0.01 | 0.03 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 20,768 | 24,267 | +3,499 | 0.05 | 0.04 | -0.01 | buy |