| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 564,579 | 1,427,124 | +862,545 | 0.03 | 0.06 | +0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | 1,568,266 | +379,642 | 4.23 | 4.48 | +0.25 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 335,834 | +335,834 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,562,154 | 2,775,649 | +213,495 | 3.67 | 3.27 | -0.40 | buy |
| Parkman Healthcare Partners LLC | 0 | 150,000 | +150,000 | 0.00 | 0.97 | +0.97 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 99,845 | +99,845 | 0.00 | 0.03 | +0.03 | buy |
| Caption Management, LLC | 36,448 | 120,700 | +84,252 | 0.12 | 0.27 | +0.15 | buy |
| CITADEL ADVISORS LLC | 163,997 | 241,737 | +77,740 | 0.01 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 252,588 | 328,340 | +75,752 | 2.49 | 2.54 | +0.05 | buy |
| Deep Track Capital, LP | 3,600,000 | 3,666,768 | +66,768 | 5.21 | 3.40 | -1.81 | buy |
| Eversept Partners, LP | 0 | 55,710 | +55,710 | 0.00 | 0.19 | +0.19 | buy |
| Squarepoint Ops LLC | 241,033 | 295,824 | +54,791 | 0.04 | 0.04 | -0.00 | buy |
| Rock Springs Capital Management LP | 225,179 | 277,087 | +51,908 | 0.93 | 0.85 | -0.08 | buy |
| XTX Topco Ltd | 51,634 | 95,130 | +43,496 | 0.06 | 0.08 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,210 | 54,671 | +43,461 | 0.01 | 0.07 | +0.05 | buy |
| Atika Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.25 | +0.25 | buy |
| ORBIMED ADVISORS LLC | 0 | 35,581 | +35,581 | 0.00 | 0.04 | +0.04 | buy |
| HighVista Strategies LLC | 52,464 | 87,060 | +34,596 | 1.02 | 1.25 | +0.23 | buy |
| Vontobel Holding Ltd. | 9,754 | 40,000 | +30,246 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 23,661 | 44,152 | +20,491 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,078 | 36,038 | +16,960 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 16,672 | +16,672 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,635 | 33,290 | +16,655 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 49,094 | 65,096 | +16,002 | 0.01 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 14,541 | 26,800 | +12,259 | 0.05 | 0.06 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,453 | 42,003 | +11,550 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 3,346,025 | 3,357,059 | +11,034 | 2.34 | 1.80 | -0.53 | buy |
| Verition Fund Management LLC | 4,460 | 15,000 | +10,540 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,616 | 51,029 | +10,413 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 34,647 | 43,365 | +8,718 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,378 | 18,771 | +8,393 | 0.20 | 0.28 | +0.07 | buy |
| Brevan Howard Capital Management LP | 0 | 7,993 | +7,993 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 106,782 | 114,458 | +7,676 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 0 | 7,121 | +7,121 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 4,021 | 10,864 | +6,843 | 0.02 | 0.04 | +0.03 | buy |
| RHUMBLINE ADVISERS | 46,958 | 52,718 | +5,760 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 24,669 | 29,659 | +4,990 | 0.09 | 0.10 | +0.01 | buy |
| Yorktown Management & Research Co Inc | 0 | 4,950 | +4,950 | 0.00 | 0.19 | +0.19 | buy |
| Quadrature Capital Ltd | 0 | 4,880 | +4,880 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 16,800 | 21,000 | +4,200 | 0.25 | 0.30 | +0.05 | buy |
| Pale Fire Capital SE | 5,652 | 9,802 | +4,150 | 0.03 | 0.04 | +0.01 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 19,704 | 23,796 | +4,092 | 0.03 | 0.02 | -0.00 | buy |
| Clearbridge Investments, LLC | 545,351 | 549,387 | +4,036 | 0.03 | 0.03 | -0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 4,018 | +4,018 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 3,712 | +3,712 | 0.00 | 0.01 | +0.01 | buy |
| Blueshift Asset Management, LLC | 0 | 3,697 | +3,697 | 0.00 | 0.05 | +0.05 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 3,799 | 7,429 | +3,630 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 4,687 | 8,004 | +3,317 | 0.05 | 0.08 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 3,242 | +3,242 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 21,794 | 24,493 | +2,699 | 0.01 | 0.01 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,272 | 13,285 | +2,013 | 0.71 | 0.58 | -0.12 | buy |
| Engineers Gate Manager LP | 2,855 | 4,755 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 3,367 | 5,111 | +1,744 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 1,643 | +1,643 | 0.00 | 0.01 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 12,769 | 14,275 | +1,506 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 2,960 | 4,190 | +1,230 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 13,800 | 15,000 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 11,604 | 12,696 | +1,092 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 4,022 | 4,993 | +971 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 6,225 | 6,930 | +705 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,556 | 19,206 | +650 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 634 | +634 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 3,272 | 3,801 | +529 | 0.01 | 0.01 | -0.00 | buy |
| XPONANCE, INC. | 3,684 | 4,128 | +444 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 25,881 | 26,291 | +410 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 2,855 | 3,202 | +347 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 29,283 | 29,612 | +329 | 0.17 | 0.13 | -0.04 | buy |
| Janney Montgomery Scott LLC | 10,535 | 10,788 | +253 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 9,483 | 9,677 | +194 | 0.01 | 0.01 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 23 | 203 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,899 | 9,067 | +168 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 4,571 | 4,667 | +96 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 327 | 378 | +51 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | 14 | 58 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 201 | 242 | +41 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 1 | 18 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 57 | 69 | +12 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 48 | 59 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 779 | 782 | +3 | 0.04 | 0.03 | -0.01 | buy |
| GABELLI FUNDS LLC | 3,600 | 3,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 110 | 110 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRIVATE TRUST CO NA | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Valmark Advisers, Inc. | 5,500 | 5,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GHP Investment Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 1,296 | 1,296 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 4,324 | 4,324 | 0 | 0.01 | 0.01 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 6,900 | 6,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 69 | 69 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 31,166 | 31,166 | 0 | 0.31 | 0.32 | +0.01 | hold |
| Woodline Partners LP | 100,443 | 100,443 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Sands Capital Alternatives, LLC | 85,000 | 85,000 | 0 | 1.42 | 0.87 | -0.54 | hold |
| Bell Investment Advisors, Inc | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 728,644 | 728,644 | 0 | 1.32 | 1.00 | -0.32 | hold |
| West Wealth Group, LLC | 3,400 | 3,400 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Truvestments Capital LLC | 909 | 907 | -2 | 0.01 | 0.01 | -0.00 | sell |
| Valeo Financial Advisors, LLC | 3,842 | 3,838 | -4 | 0.01 | 0.01 | -0.00 | sell |