| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,552,612 | 3,856,137 | +303,525 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 3,600,000 | 3,666,768 | +66,768 | 5.21 | 3.40 | -1.81 | buy |
| RTW INVESTMENTS, LP | 3,346,025 | 3,357,059 | +11,034 | 2.34 | 1.80 | -0.53 | buy |
| Paradigm Biocapital Advisors LP | 2,562,154 | 2,775,649 | +213,495 | 3.67 | 3.27 | -0.40 | buy |
| MORGAN STANLEY | 1,944,272 | 1,827,082 | -117,190 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 1,712,124 | 1,663,655 | -48,469 | 0.08 | 0.06 | -0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,188,624 | 1,568,266 | +379,642 | 4.23 | 4.48 | +0.25 | buy |
| MILLENNIUM MANAGEMENT LLC | 564,579 | 1,427,124 | +862,545 | 0.03 | 0.06 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 1,194,377 | 1,193,182 | -1,195 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,121,091 | 1,105,689 | -15,402 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 978,212 | 1,072,951 | +94,739 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 200,000 | 1,050,000 | +850,000 | 0.39 | 1.54 | +1.15 | buy |
| Assenagon Asset Management S.A. | 1,280,194 | 947,495 | -332,699 | 0.14 | 0.08 | -0.07 | sell |
| Invesco Ltd. | 742,497 | 785,808 | +43,311 | 0.01 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 439,626 | 742,693 | +303,067 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 728,644 | 728,644 | 0 | 1.32 | 1.00 | -0.32 | hold |
| D. E. Shaw & Co., Inc. | 791,146 | 710,559 | -80,587 | 0.04 | 0.03 | -0.02 | sell |
| FMR LLC | 733,334 | 672,949 | -60,385 | 0.00 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 545,351 | 549,387 | +4,036 | 0.03 | 0.03 | -0.00 | buy |
| TORONTO DOMINION BANK | 510,253 | 510,253 | 0 | 0.07 | 0.05 | -0.02 | hold |
| LORD, ABBETT & CO. LLC | 842,313 | 479,266 | -363,047 | 0.19 | 0.09 | -0.11 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 427,008 | +427,008 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 352,957 | 386,611 | +33,654 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 407,836 | 380,684 | -27,152 | 0.04 | 0.03 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 388,590 | 369,377 | -19,213 | 0.46 | 0.34 | -0.12 | sell |
| WASATCH ADVISORS LP | 0 | 368,568 | +368,568 | 0.00 | 0.15 | +0.15 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 335,834 | +335,834 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,162 | 335,834 | +7,672 | 0.00 | 0.00 | -0.00 | buy |
| Tri Locum Partners LP | 252,588 | 328,340 | +75,752 | 2.49 | 2.54 | +0.05 | buy |
| MPM BioImpact LLC | 329,750 | 322,007 | -7,743 | 1.79 | 1.24 | -0.55 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 926,125 | 317,576 | -608,549 | 0.48 | 0.12 | -0.36 | sell |
| Squarepoint Ops LLC | 241,033 | 295,824 | +54,791 | 0.04 | 0.04 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 333,676 | 286,008 | -47,668 | 0.01 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 307,307 | 284,899 | -22,408 | 0.04 | 0.03 | -0.01 | sell |
| Rock Springs Capital Management LP | 225,179 | 277,087 | +51,908 | 0.93 | 0.85 | -0.08 | buy |
| Ensign Peak Advisors, Inc | 332,982 | 268,696 | -64,286 | 0.04 | 0.03 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 274,804 | 260,784 | -14,020 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 163,997 | 241,737 | +77,740 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 303,509 | 201,624 | -101,885 | 0.01 | 0.01 | -0.01 | sell |
| MACKENZIE FINANCIAL CORP | 0 | 191,428 | +191,428 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 150,000 | +150,000 | 0.00 | 0.97 | +0.97 | buy |
| JPMORGAN CHASE & CO | 30,478 | 139,981 | +109,503 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 131,612 | 130,329 | -1,283 | 0.02 | 0.01 | -0.00 | sell |
| Caption Management, LLC | 36,448 | 120,700 | +84,252 | 0.12 | 0.27 | +0.15 | buy |
| Jefferies Financial Group Inc. | 118,810 | 118,810 | 0 | 0.10 | 0.07 | -0.03 | hold |
| FIRST TRUST ADVISORS LP | 122,911 | 117,811 | -5,100 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 324,014 | 116,363 | -207,651 | 0.03 | 0.01 | -0.02 | sell |
| Bank of New York Mellon Corp | 106,782 | 114,458 | +7,676 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 89,293 | 111,639 | +22,346 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 100,443 | 100,443 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Cormorant Asset Management, LP | 225,000 | 100,000 | -125,000 | 0.80 | 0.32 | -0.47 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 99,845 | +99,845 | 0.00 | 0.03 | +0.03 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 152,200 | 98,900 | -53,300 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 315,290 | 96,819 | -218,471 | 0.01 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 51,634 | 95,130 | +43,496 | 0.06 | 0.08 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 111,437 | 90,969 | -20,468 | 0.02 | 0.01 | -0.01 | sell |
| Russell Investments Group, Ltd. | 145,926 | 88,828 | -57,098 | 0.01 | 0.00 | -0.01 | sell |
| HighVista Strategies LLC | 52,464 | 87,060 | +34,596 | 1.02 | 1.25 | +0.23 | buy |
| Sands Capital Alternatives, LLC | 85,000 | 85,000 | 0 | 1.42 | 0.87 | -0.54 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 80,892 | 79,888 | -1,004 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 82,124 | 73,528 | -8,596 | 0.00 | 0.00 | -0.00 | sell |
| Freestone Grove Partners LP | 0 | 68,389 | +68,389 | 0.00 | 0.03 | +0.03 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 71,135 | 67,825 | -3,310 | 0.06 | 0.04 | -0.02 | sell |
| CITIGROUP INC | 54,335 | 67,298 | +12,963 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 121,862 | 65,457 | -56,405 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 49,094 | 65,096 | +16,002 | 0.01 | 0.01 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 108,800 | 61,600 | -47,200 | 0.01 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 62,706 | 61,514 | -1,192 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 62,933 | 59,733 | -3,200 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 67,087 | 59,681 | -7,406 | 0.01 | 0.01 | -0.00 | sell |
| Eversept Partners, LP | 0 | 55,710 | +55,710 | 0.00 | 0.19 | +0.19 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,210 | 54,671 | +43,461 | 0.01 | 0.07 | +0.05 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 53,636 | +53,636 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 46,958 | 52,718 | +5,760 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,616 | 51,029 | +10,413 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 68,769 | 46,182 | -22,587 | 0.32 | 0.12 | -0.20 | sell |
| E. Ohman J:or Asset Management AB | 42,087 | 45,794 | +3,707 | 0.08 | 0.07 | -0.01 | buy |
| Trexquant Investment LP | 23,661 | 44,152 | +20,491 | 0.01 | 0.02 | +0.01 | buy |
| Voleon Capital Management LP | 68,935 | 43,405 | -25,530 | 0.10 | 0.05 | -0.05 | sell |
| ALPS ADVISORS INC | 34,647 | 43,365 | +8,718 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,453 | 42,003 | +11,550 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 80,226 | 40,579 | -39,647 | 0.59 | 0.22 | -0.37 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 16,085 | 40,202 | +24,117 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 9,754 | 40,000 | +30,246 | 0.00 | 0.01 | +0.01 | buy |
| Atika Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.25 | +0.25 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 35,918 | 39,303 | +3,385 | 0.00 | 0.00 | -0.00 | buy |
| Baird Financial Group, Inc. | 41,977 | 38,898 | -3,079 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,404 | 38,198 | +794 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 9,643 | 38,090 | +28,447 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 28,004 | 36,658 | +8,654 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,695 | 36,365 | -1,330 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 19,078 | 36,038 | +16,960 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 35,581 | +35,581 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,635 | 33,290 | +16,655 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 63,026 | 32,292 | -30,734 | 0.26 | 0.11 | -0.15 | sell |
| Ikarian Capital, LLC | 31,166 | 31,166 | 0 | 0.31 | 0.32 | +0.01 | hold |
| RAYMOND JAMES FINANCIAL INC | 34,784 | 29,945 | -4,839 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 24,669 | 29,659 | +4,990 | 0.09 | 0.10 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 29,283 | 29,612 | +329 | 0.17 | 0.13 | -0.04 | buy |
| Legal & General Group Plc | 24,896 | 27,743 | +2,847 | 0.00 | 0.00 | -0.00 | buy |