| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,412,486 | 3,412,486 | 0 | 1.44 | 1.62 | +0.19 | hold |
| Paradigm Biocapital Advisors LP | 2,435,416 | 2,440,445 | +5,029 | 2.53 | 2.81 | +0.28 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,254,797 | 2,254,797 | 0 | 6.24 | 5.30 | -0.94 | hold |
| MORGAN STANLEY | 1,884,685 | 2,208,588 | +323,903 | 0.00 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,479,868 | 2,178,580 | +698,712 | 0.03 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 1,989,693 | 2,097,323 | +107,630 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,587,527 | 1,587,527 | 0 | 2.02 | 2.09 | +0.07 | hold |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 1,296,416 | 0 | 0.85 | 0.91 | +0.06 | hold |
| Assenagon Asset Management S.A. | 1,063,422 | 1,141,247 | +77,825 | 0.07 | 0.08 | +0.01 | buy |
| Ikarian Capital, LLC | 800,277 | 1,030,277 | +230,000 | 6.79 | 10.52 | +3.74 | buy |
| STATE STREET CORP | 925,639 | 899,379 | -26,260 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 670,459 | 883,043 | +212,584 | 0.20 | 0.30 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 773,235 | 835,790 | +62,555 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 627,578 | 709,018 | +81,440 | 0.03 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 391,563 | 682,097 | +290,534 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 500,000 | 614,117 | +114,117 | 4.21 | 6.44 | +2.22 | buy |
| MACQUARIE GROUP LTD | 454,991 | 594,878 | +139,887 | 0.01 | 0.02 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 463,240 | 594,876 | +131,636 | 0.04 | 0.06 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 594,325 | 587,030 | -7,295 | 0.03 | 0.03 | +0.00 | sell |
| J. Goldman & Co LP | 387,161 | 557,500 | +170,339 | 0.39 | 0.80 | +0.41 | buy |
| Cormorant Asset Management, LP | 500,000 | 500,000 | 0 | 0.79 | 0.87 | +0.08 | hold |
| JPMORGAN CHASE & CO | 20,110 | 440,167 | +420,057 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 420,758 | 420,758 | 0 | 0.22 | 0.23 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 406,899 | 403,963 | -2,936 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 207,489 | 384,467 | +176,978 | 0.01 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 590,000 | 375,000 | -215,000 | 1.60 | 1.45 | -0.14 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 389,600 | 338,400 | -51,200 | 0.03 | 0.03 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 321,898 | +321,898 | 0.00 | 5.67 | +5.67 | buy |
| NORTHERN TRUST CORP | 253,016 | 317,555 | +64,539 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 434,342 | 296,003 | -138,339 | 0.03 | 0.02 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 261,879 | 290,009 | +28,130 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 200,094 | 275,563 | +75,469 | 0.16 | 0.27 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 205,551 | 268,775 | +63,224 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 307,600 | 256,400 | -51,200 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 291,275 | 239,315 | -51,960 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 243,112 | 233,468 | -9,644 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 556,317 | 231,820 | -324,497 | 1.58 | 0.65 | -0.93 | sell |
| Vestal Point Capital, LP | 0 | 230,000 | +230,000 | 0.00 | 0.60 | +0.60 | buy |
| MILLENNIUM MANAGEMENT LLC | 348,586 | 222,515 | -126,071 | 0.01 | 0.01 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 181,066 | 210,531 | +29,465 | 0.01 | 0.01 | +0.00 | buy |
| AIGH Capital Management LLC | 0 | 204,413 | +204,413 | 0.00 | 3.15 | +3.15 | buy |
| Clearbridge Investments, LLC | 0 | 191,374 | +191,374 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 28,137 | 187,513 | +159,376 | 0.01 | 0.05 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 269,793 | 182,095 | -87,698 | 0.01 | 0.01 | -0.00 | sell |
| Sands Capital Alternatives, LLC | 170,000 | 170,000 | 0 | 1.55 | 1.57 | +0.02 | hold |
| Baird Financial Group, Inc. | 123,778 | 146,436 | +22,658 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 0 | 146,298 | +146,298 | 0.00 | 0.19 | +0.19 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,328 | 145,347 | +18,019 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 130,454 | +130,454 | 0.00 | 0.05 | +0.05 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 109,692 | +109,692 | 0.00 | 0.19 | +0.19 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 109,156 | +109,156 | 0.00 | 0.63 | +0.63 | buy |
| PRUDENTIAL FINANCIAL INC | 79,515 | 103,495 | +23,980 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 102,555 | 102,555 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Bank of New York Mellon Corp | 122,634 | 101,430 | -21,204 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,125 | 98,663 | +76,538 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,990 | 79,166 | +63,176 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 74,957 | +74,957 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 0 | 71,569 | +71,569 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 27,973 | 69,316 | +41,343 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 226,879 | 64,683 | -162,196 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 53,126 | 58,835 | +5,709 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 57,333 | +57,333 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 47,333 | 51,733 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,660 | 48,515 | -1,145 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 85,323 | 47,060 | -38,263 | 0.01 | 0.01 | -0.00 | sell |
| E. Ohman J:or Asset Management AB | 38,981 | 46,981 | +8,000 | 0.03 | 0.04 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 45,600 | +45,600 | 0.00 | 1.01 | +1.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,065 | 45,357 | -1,708 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,499 | 44,604 | +5,105 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 44,160 | +44,160 | 0.00 | 0.18 | +0.18 | buy |
| Brevan Howard Capital Management LP | 0 | 43,380 | +43,380 | 0.00 | 0.07 | +0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 40,000 | 40,000 | 0 | 0.27 | 0.30 | +0.03 | hold |
| Lisanti Capital Growth, LLC | 0 | 39,845 | +39,845 | 0.00 | 0.33 | +0.33 | buy |
| WELLS FARGO & COMPANY/MN | 13,483 | 39,553 | +26,070 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 48,148 | 39,349 | -8,799 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,120 | 38,250 | +3,130 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 37,811 | 37,811 | 0 | 0.02 | 0.02 | 0.00 | hold |
| SEI INVESTMENTS CO | 21,298 | 35,491 | +14,193 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,750 | 33,435 | +17,685 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,282 | 32,929 | -353 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 35,388 | 29,788 | -5,600 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 29,468 | 29,242 | -226 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 78,847 | 27,581 | -51,266 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 25,900 | +25,900 | 0.00 | 0.14 | +0.14 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,411 | 25,754 | +1,343 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 22,975 | 25,075 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,486 | 24,579 | +93 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 23,199 | +23,199 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 22,493 | +22,493 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 21,504 | 21,504 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Janney Montgomery Scott LLC | 23,068 | 21,068 | -2,000 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,643 | 20,202 | +5,559 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 7,493 | 19,920 | +12,427 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 19,790 | 19,669 | -121 | 0.00 | 0.00 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 11,493 | 18,105 | +6,612 | 0.02 | 0.03 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 17,684 | +17,684 | 0.00 | 0.07 | +0.07 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 10,537 | 14,415 | +3,878 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 13,400 | +13,400 | 0.00 | 0.03 | +0.03 | buy |
| IEQ CAPITAL, LLC | 12,754 | 12,640 | -114 | 0.00 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 12,454 | +12,454 | 0.00 | 0.00 | +0.00 | buy |