| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,792,185 | 3,779,621 | -12,564 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 3,111,680 | 3,177,436 | +65,756 | 1.80 | 2.33 | +0.53 | buy |
| Deep Track Capital, LP | 1,750,000 | 3,000,000 | +1,250,000 | 2.28 | 4.98 | +2.70 | buy |
| Paradigm Biocapital Advisors LP | 2,976,099 | 2,665,698 | -310,401 | 5.15 | 4.69 | -0.46 | sell |
| JENNISON ASSOCIATES LLC | 2,467,998 | 2,604,580 | +136,582 | 0.06 | 0.09 | +0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,454,797 | 2,454,797 | 0 | 5.03 | 5.62 | +0.59 | hold |
| VANGUARD GROUP INC | 2,297,354 | 2,272,090 | -25,264 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 2,055,718 | 1,912,402 | -143,316 | 0.01 | 0.01 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,806,947 | 1,438,999 | -367,948 | 0.04 | 0.04 | +0.00 | sell |
| Assenagon Asset Management S.A. | 997,587 | 1,247,954 | +250,367 | 0.06 | 0.11 | +0.05 | buy |
| Frazier Life Sciences Management, L.P. | 1,397,527 | 1,167,527 | -230,000 | 2.26 | 2.08 | -0.18 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 876,547 | 1,031,041 | +154,494 | 0.28 | 0.44 | +0.15 | buy |
| LORD, ABBETT & CO. LLC | 995,425 | 985,629 | -9,796 | 0.13 | 0.17 | +0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 934,420 | 944,496 | +10,076 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 928,501 | 937,006 | +8,505 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 980,868 | 936,162 | -44,706 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 948,850 | 833,437 | -115,413 | 0.05 | 0.06 | +0.01 | sell |
| TORONTO DOMINION BANK | 1,001,962 | 617,583 | -384,379 | 0.09 | 0.07 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 723,183 | 598,307 | -124,876 | 0.03 | 0.03 | -0.00 | sell |
| Clearbridge Investments, LLC | 444,502 | 566,978 | +122,476 | 0.01 | 0.03 | +0.01 | buy |
| Artisan Partners Limited Partnership | 539,303 | 558,326 | +19,023 | 0.03 | 0.05 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 466,280 | 536,023 | +69,743 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 459,436 | 522,276 | +62,840 | 0.03 | 0.04 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 487,310 | 482,364 | -4,946 | 0.03 | 0.05 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 383,902 | 452,857 | +68,955 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 389,901 | +389,901 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 357,178 | 358,102 | +924 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 341,496 | 341,496 | 0 | 2.40 | 3.32 | +0.93 | hold |
| GOLDMAN SACHS GROUP INC | 397,994 | 341,012 | -56,982 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,297 | 332,912 | +3,615 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 336,939 | 330,680 | -6,259 | 0.00 | 0.01 | +0.00 | sell |
| Cormorant Asset Management, LP | 300,000 | 300,000 | 0 | 0.91 | 1.23 | +0.32 | hold |
| Rock Springs Capital Management LP | 373,750 | 288,344 | -85,406 | 0.94 | 1.00 | +0.06 | sell |
| TimesSquare Capital Management, LLC | 0 | 267,505 | +267,505 | 0.00 | 0.23 | +0.23 | buy |
| Jump Financial, LLC | 237,117 | 266,005 | +28,888 | 0.12 | 0.24 | +0.11 | buy |
| Integral Health Asset Management, LLC | 200,000 | 250,000 | +50,000 | 0.76 | 1.08 | +0.33 | buy |
| Capricorn Fund Managers Ltd | 0 | 240,020 | +240,020 | 0.00 | 4.79 | +4.79 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 152,309 | 204,300 | +51,991 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 197,900 | 197,900 | 0 | 0.20 | 0.28 | +0.08 | hold |
| DEUTSCHE BANK AG\ | 102,369 | 184,450 | +82,081 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 170,000 | 170,000 | 0 | 1.36 | 2.21 | +0.86 | hold |
| Russell Investments Group, Ltd. | 145,240 | 148,329 | +3,089 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 8,500 | 131,300 | +122,800 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 132,562 | 128,737 | -3,825 | 0.01 | 0.01 | +0.00 | sell |
| TFG Asset Management GP Ltd | 250,000 | 125,000 | -125,000 | 1.83 | 1.08 | -0.75 | sell |
| Affinity Asset Advisors, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.69 | +0.69 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 132,978 | 122,341 | -10,637 | 0.06 | 0.08 | +0.02 | sell |
| Tri Locum Partners LP | 177,656 | 119,260 | -58,396 | 2.18 | 1.63 | -0.55 | sell |
| UBS Group AG | 28,506 | 118,562 | +90,056 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 162,996 | 113,069 | -49,927 | 0.11 | 0.06 | -0.05 | sell |
| Bank of New York Mellon Corp | 106,792 | 109,376 | +2,584 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 60,495 | 103,811 | +43,316 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 58,141 | 100,568 | +42,427 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 100,149 | 100,154 | +5 | 0.02 | 0.03 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 126,953 | 98,751 | -28,202 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 127,579 | 92,126 | -35,453 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 51,752 | 91,590 | +39,838 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 92,134 | 91,171 | -963 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 102,642 | 81,479 | -21,163 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 140,610 | 77,190 | -63,420 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 73,955 | +73,955 | 0.00 | 0.06 | +0.06 | buy |
| Pictet Asset Management Holding SA | 80,220 | 73,647 | -6,573 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 196,536 | 73,619 | -122,917 | 2.63 | 0.89 | -1.75 | sell |
| Ally Bridge Group (NY) LLC | 121,182 | 70,778 | -50,404 | 4.08 | 3.52 | -0.56 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 79,851 | 66,954 | -12,897 | 0.00 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 63,026 | 63,026 | 0 | 0.14 | 0.24 | +0.09 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,378 | 62,603 | -23,775 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 63,533 | 61,133 | -2,400 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 60,620 | +60,620 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 58,613 | 58,827 | +214 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,650 | 56,523 | -1,127 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 53,028 | 53,999 | +971 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 61,681 | 53,878 | -7,803 | 0.00 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 43,292 | 52,692 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 105,090 | 51,897 | -53,193 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 61,597 | 51,678 | -9,919 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 44,715 | 49,339 | +4,624 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,004 | 48,607 | +5,603 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 364,557 | 44,300 | -320,257 | 0.46 | 0.10 | -0.36 | sell |
| CITADEL ADVISORS LLC | 229,246 | 43,281 | -185,965 | 0.01 | 0.00 | -0.01 | sell |
| Lisanti Capital Growth, LLC | 75,525 | 43,011 | -32,514 | 0.85 | 0.63 | -0.22 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 41,600 | +41,600 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,054 | 40,954 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 22,794 | 40,591 | +17,797 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 41,023 | 38,323 | -2,700 | 0.04 | 0.05 | +0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 23,533 | 37,102 | +13,569 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 53,568 | 37,095 | -16,473 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 36,127 | 31,995 | -4,132 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 30,058 | 31,580 | +1,522 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,973 | 31,580 | +7,607 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 31,500 | +31,500 | 0.00 | 0.41 | +0.41 | buy |
| Legal & General Group Plc | 35,426 | 31,311 | -4,115 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,364 | 30,183 | +4,819 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 11,680 | 24,854 | +13,174 | 0.17 | 0.36 | +0.19 | buy |
| MetLife Investment Management, LLC | 23,095 | 23,095 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Voleon Capital Management LP | 0 | 22,983 | +22,983 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 22,427 | +22,427 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 21,402 | 22,183 | +781 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 19,850 | 21,861 | +2,011 | 0.00 | 0.00 | +0.00 | buy |