| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 73,819 | 1,957,688 | +1,883,869 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,025,000 | +1,025,000 | 0.00 | 0.97 | +0.97 | buy |
| RTW INVESTMENTS, LP | 2,880,701 | 3,152,341 | +271,640 | 1.08 | 1.00 | -0.08 | buy |
| Nantahala Capital Management, LLC | 135,500 | 375,276 | +239,776 | 0.31 | 0.76 | +0.46 | buy |
| TFG Asset Management GP Ltd | 615,000 | 800,000 | +185,000 | 1.99 | 4.11 | +2.12 | buy |
| NORGES BANK | 0 | 160,100 | +160,100 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 100,062 | 237,439 | +137,377 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 544,932 | 674,831 | +129,899 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.29 | +0.29 | buy |
| Invesco Ltd. | 0 | 97,873 | +97,873 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 143,292 | 238,823 | +95,531 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 91,423 | +91,423 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 526,260 | 609,736 | +83,476 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 355,683 | 430,127 | +74,444 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 74,000 | +74,000 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 0 | 72,032 | +72,032 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,140,586 | 2,204,797 | +64,211 | 5.37 | 4.13 | -1.24 | buy |
| Jefferies Financial Group Inc. | 330,758 | 380,758 | +50,000 | 0.15 | 0.12 | -0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 40,701 | 90,083 | +49,382 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 1,551,802 | 1,595,501 | +43,699 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 40,527 | +40,527 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 39,497 | +39,497 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 211,290 | 248,750 | +37,460 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 5,864 | 43,037 | +37,173 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,637 | 47,259 | +35,622 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,394 | 218,662 | +30,268 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.04 | +0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 18,966 | +18,966 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 54,098 | 71,940 | +17,842 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 17,061 | +17,061 | 0.00 | 0.22 | +0.22 | buy |
| Bayesian Capital Management, LP | 0 | 15,400 | +15,400 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 19,001 | 30,493 | +11,492 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,442 | +11,442 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 11,334 | +11,334 | 0.00 | 0.00 | +0.00 | buy |
| Sargent Investment Group, LLC | 0 | 11,117 | +11,117 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 71,452 | 82,197 | +10,745 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,918 | +7,918 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,150 | 11,980 | +7,830 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 6,283 | 13,214 | +6,931 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 10,859 | 17,754 | +6,895 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 5,828 | +5,828 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 36,006 | 41,620 | +5,614 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 61,100 | 66,300 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 4,700 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 50,713 | 54,979 | +4,266 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 3,632 | +3,632 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 22,102 | 25,570 | +3,468 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 828 | 3,832 | +3,004 | 0.00 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 12,768 | 15,540 | +2,772 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,324 | 9,863 | +2,539 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 21,727 | 24,227 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 11,767 | 14,263 | +2,496 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 20,552 | 22,831 | +2,279 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,947 | 2,970 | +1,023 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,736 | 4,560 | +824 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 10,427 | 11,075 | +648 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,104 | 1,617 | +513 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 20,750 | 20,950 | +200 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,284 | 2,447 | +163 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 53,305 | 53,450 | +145 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 115 | +115 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 11,163 | 11,226 | +63 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 25 | 77 | +52 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 1,296,416 | 0 | 0.77 | 0.59 | -0.19 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,306 | 5,306 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 150,000 | 150,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 437,891 | 437,891 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Daiwa Securities Group Inc. | 107 | 107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,772 | 111,772 | 0 | 0.06 | 0.08 | +0.01 | hold |
| Venturi Wealth Management, LLC | 861 | 861 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 59 | 59 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 518,519 | 518,519 | 0 | 3.42 | 2.87 | -0.55 | hold |
| TCG Crossover Management, LLC | 1,142,857 | 1,142,857 | 0 | 2.99 | 2.57 | -0.42 | hold |
| Sands Capital Alternatives, LLC | 260,000 | 260,000 | 0 | 1.37 | 1.46 | +0.10 | hold |
| Frazier Life Sciences Management, L.P. | 1,787,527 | 1,787,527 | 0 | 2.11 | 1.94 | -0.18 | hold |
| HUNTINGTON NATIONAL BANK | 1,501 | 1,501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,657 | 1,657 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SALEM INVESTMENT COUNSELORS INC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 10 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 43 | 0 | -43 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,566 | 26,518 | -48 | 0.00 | 0.00 | +0.00 | sell |
| Spire Wealth Management | 146 | 66 | -80 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 130 | 0 | -130 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 11,291 | 11,051 | -240 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,214 | 14,368 | -846 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,324 | 23,590 | -1,734 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 24,105 | 21,827 | -2,278 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 21,021 | 14,056 | -6,965 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 49,433 | 41,833 | -7,600 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 399,177 | 390,011 | -9,166 | 0.01 | 0.01 | +0.00 | sell |
| Verition Fund Management LLC | 10,600 | 0 | -10,600 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 12,903 | 0 | -12,903 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 19,344 | 0 | -19,344 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 38,813 | 19,156 | -19,657 | 0.00 | 0.00 | -0.00 | sell |
| Channing Capital Management, LLC | 21,223 | 0 | -21,223 | 0.01 | 0.00 | -0.01 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 43,707 | 0 | -43,707 | 0.10 | 0.00 | -0.10 | sell |
| SEI INVESTMENTS CO | 63,613 | 14,378 | -49,235 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 50,000 | 0 | -50,000 | 0.01 | 0.00 | -0.01 | sell |