| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,880,701 | 3,152,341 | +271,640 | 1.08 | 1.00 | -0.08 | buy |
| Nantahala Capital Management, LLC | 135,500 | 375,276 | +239,776 | 0.21 | 0.45 | +0.25 | buy |
| TFG Asset Management GP Ltd | 615,000 | 800,000 | +185,000 | 1.99 | 3.90 | +1.91 | buy |
| ExodusPoint Capital Management, LP | 398,641 | 232,900 | +165,741 | 0.09 | 0.06 | 0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,140,586 | 2,204,797 | +64,211 | 5.37 | 4.13 | -1.24 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 40,701 | 90,083 | +49,382 | 0.00 | 0.01 | +0.00 | buy |
| IEQ CAPITAL, LLC | 10,859 | 17,754 | +6,895 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 828 | 3,832 | +3,004 | 0.00 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 24,105 | 21,827 | -2,278 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 399,177 | 390,011 | -9,166 | 0.01 | 0.01 | +0.00 | sell |
| J. Goldman & Co LP | 125,909 | 72,344 | -53,565 | 0.08 | 0.06 | -0.02 | sell |
| Cormorant Asset Management, LP | 2,621,422 | 2,221,422 | -400,000 | 2.72 | 2.15 | -0.57 | sell |
| Vivo Capital, LLC | 2,262,200 | 1,784,006 | -478,194 | 4.40 | 2.96 | -1.45 | sell |