| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 594,876 | 1,279,987 | +685,111 | 0.06 | 0.22 | +0.16 | buy |
| GILDER GAGNON HOWE & CO LLC | 7,047 | 404,237 | +397,190 | 0.00 | 0.24 | +0.24 | buy |
| JENNISON ASSOCIATES LLC | 2,178,580 | 2,500,132 | +321,552 | 0.04 | 0.08 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 2,440,445 | 2,531,896 | +91,451 | 2.81 | 4.88 | +2.07 | buy |
| Lisanti Capital Growth, LLC | 39,845 | 96,935 | +57,090 | 0.33 | 1.29 | +0.96 | buy |
| Woodline Partners LP | 71,569 | 108,986 | +37,417 | 0.02 | 0.04 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 210,531 | 181,122 | +29,409 | 0.01 | 0.02 | 0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 40,000 | 65,955 | +25,955 | 0.30 | 0.82 | +0.52 | buy |
| AIGH Capital Management LLC | 204,413 | 224,713 | +20,300 | 3.15 | 4.68 | +1.54 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,300 | 20,300 | +9,000 | 0.22 | 0.75 | +0.53 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 18,105 | 22,113 | +4,008 | 0.03 | 0.05 | 0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 9,979 | 12,383 | +2,404 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 29,242 | 30,906 | +1,664 | 0.01 | 0.01 | +0.00 | buy |
| Legato Capital Management LLC | 44,160 | 45,656 | +1,496 | 0.18 | 0.33 | +0.15 | buy |
| China Universal Asset Management Co., Ltd. | 7,317 | 8,106 | +789 | 0.03 | 0.04 | +0.02 | buy |
| SHERBROOKE PARK ADVISERS LLC | 6,128 | 6,571 | +443 | 0.05 | 0.12 | +0.07 | buy |
| PROFUND ADVISORS LLC | 8,701 | 8,436 | +265 | 0.01 | 0.02 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,938 | 6,845 | -3,093 | 0.15 | 0.15 | +0.00 | sell |
| Sargent Investment Group, LLC | 8,093 | 4,465 | -3,628 | 0.05 | 0.03 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,400 | 8,778 | -4,622 | 0.03 | 0.04 | +0.01 | sell |
| Aberdeen Group plc | 102,555 | 93,650 | -8,905 | 0.01 | 0.01 | +0.00 | sell |
| E. Ohman J:or Asset Management AB | 46,981 | 34,781 | -12,200 | 0.04 | 0.04 | +0.01 | sell |
| Exome Asset Management LLC | 45,600 | 28,178 | -17,422 | 1.01 | 1.17 | +0.16 | sell |
| Artisan Partners Limited Partnership | 709,018 | 691,299 | -17,719 | 0.03 | 0.06 | +0.02 | sell |
| Integral Health Asset Management, LLC | 375,000 | 350,000 | -25,000 | 1.45 | 1.71 | +0.26 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 109,156 | 79,760 | -29,396 | 0.63 | 0.79 | +0.17 | sell |
| Ally Bridge Group (NY) LLC | 321,898 | 173,144 | -148,754 | 5.67 | 8.22 | +2.55 | sell |
| RTW INVESTMENTS, LP | 3,412,486 | 3,236,549 | -175,937 | 1.62 | 2.71 | +1.09 | sell |
| TFG Asset Management GP Ltd | 614,117 | 200,000 | -414,117 | 5.70 | 2.83 | -2.87 | sell |
| Ikarian Capital, LLC | 1,030,277 | 607,689 | -422,588 | 10.52 | 9.61 | -0.91 | sell |
| J. Goldman & Co LP | 557,500 | 130,195 | -427,305 | 0.51 | 0.19 | -0.33 | sell |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 186,662 | -1,109,754 | 0.90 | 0.28 | -0.62 | sell |