| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,755,504 | 3,538,845 | -216,659 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 3,412,486 | 3,236,549 | -175,937 | 1.62 | 2.71 | +1.09 | sell |
| Paradigm Biocapital Advisors LP | 2,440,445 | 2,531,896 | +91,451 | 2.81 | 4.88 | +2.07 | buy |
| JENNISON ASSOCIATES LLC | 2,178,580 | 2,500,132 | +321,552 | 0.04 | 0.08 | +0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,254,797 | 2,254,797 | 0 | 5.30 | 8.26 | +2.96 | hold |
| VANGUARD GROUP INC | 2,097,323 | 2,115,162 | +17,839 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,208,588 | 1,969,071 | -239,517 | 0.01 | 0.01 | +0.00 | sell |
| TORONTO DOMINION BANK | 0 | 1,909,228 | +1,909,228 | 0.00 | 0.20 | +0.20 | buy |
| Frazier Life Sciences Management, L.P. | 1,587,527 | 1,587,527 | 0 | 2.09 | 3.65 | +1.56 | hold |
| LORD, ABBETT & CO. LLC | 594,876 | 1,279,987 | +685,111 | 0.06 | 0.22 | +0.16 | buy |
| Assenagon Asset Management S.A. | 1,141,247 | 1,146,812 | +5,565 | 0.08 | 0.11 | +0.04 | buy |
| Invesco Ltd. | 682,097 | 932,115 | +250,018 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 899,379 | 916,856 | +17,477 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 835,790 | 838,804 | +3,014 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 594,878 | 815,912 | +221,034 | 0.02 | 0.05 | +0.03 | buy |
| Artisan Partners Limited Partnership | 709,018 | 691,299 | -17,719 | 0.03 | 0.06 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 222,515 | 644,010 | +421,495 | 0.01 | 0.03 | +0.02 | buy |
| Ikarian Capital, LLC | 1,030,277 | 607,689 | -422,588 | 10.52 | 9.61 | -0.91 | sell |
| Ensign Peak Advisors, Inc | 587,030 | 570,056 | -16,974 | 0.03 | 0.06 | +0.02 | sell |
| Cormorant Asset Management, LP | 500,000 | 500,000 | 0 | 0.87 | 1.52 | +0.65 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 239,315 | 460,773 | +221,458 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 420,758 | 420,758 | 0 | 0.23 | 0.26 | +0.03 | hold |
| GILDER GAGNON HOWE & CO LLC | 7,047 | 404,237 | +397,190 | 0.00 | 0.24 | +0.24 | buy |
| D. E. Shaw & Co., Inc. | 182,095 | 365,544 | +183,449 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 317,555 | 357,616 | +40,061 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 375,000 | 350,000 | -25,000 | 1.45 | 1.71 | +0.26 | sell |
| DIMENSIONAL FUND ADVISORS LP | 403,963 | 341,305 | -62,658 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 233,468 | 337,856 | +104,388 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 268,775 | 318,730 | +49,955 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 290,009 | 293,700 | +3,691 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 204,413 | 224,713 | +20,300 | 3.15 | 4.68 | +1.54 | buy |
| TFG Asset Management GP Ltd | 614,117 | 200,000 | -414,117 | 6.44 | 3.57 | -2.86 | sell |
| PERCEPTIVE ADVISORS LLC | 1,296,416 | 186,662 | -1,109,754 | 0.91 | 0.29 | -0.63 | sell |
| Allspring Global Investments Holdings, LLC | 210,531 | 181,122 | -29,409 | 0.01 | 0.02 | +0.01 | sell |
| Atika Capital Management LLC | 0 | 177,200 | +177,200 | 0.00 | 1.27 | +1.27 | buy |
| Ally Bridge Group (NY) LLC | 321,898 | 173,144 | -148,754 | 5.67 | 8.22 | +2.55 | sell |
| Sands Capital Alternatives, LLC | 170,000 | 170,000 | 0 | 1.57 | 2.05 | +0.48 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 275,563 | 156,403 | -119,160 | 0.27 | 0.26 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 79,166 | 153,441 | +74,275 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 103,495 | 148,735 | +45,240 | 0.00 | 0.01 | +0.01 | buy |
| Baird Financial Group, Inc. | 146,436 | 142,419 | -4,017 | 0.01 | 0.02 | +0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 145,347 | 136,795 | -8,552 | 0.00 | 0.00 | +0.00 | sell |
| J. Goldman & Co LP | 557,500 | 130,195 | -427,305 | 0.80 | 0.25 | -0.54 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 130,454 | 130,097 | -357 | 0.05 | 0.08 | +0.03 | sell |
| JPMORGAN CHASE & CO | 440,167 | 129,184 | -310,983 | 0.00 | 0.00 | -0.00 | sell |
| Cutter Capital Management, LP | 0 | 112,500 | +112,500 | 0.00 | 2.55 | +2.55 | buy |
| Rock Springs Capital Management LP | 0 | 110,889 | +110,889 | 0.00 | 0.23 | +0.23 | buy |
| Woodline Partners LP | 71,569 | 108,986 | +37,417 | 0.02 | 0.04 | +0.02 | buy |
| Bank of New York Mellon Corp | 101,430 | 101,928 | +498 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 64,683 | 97,996 | +33,313 | 0.00 | 0.01 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 39,845 | 96,935 | +57,090 | 0.33 | 1.29 | +0.96 | buy |
| Aberdeen Group plc | 102,555 | 93,650 | -8,905 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 296,003 | 91,171 | -204,832 | 0.02 | 0.01 | -0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 600 | 82,300 | +81,700 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 109,156 | 79,760 | -29,396 | 0.63 | 0.79 | +0.17 | sell |
| CITADEL ADVISORS LLC | 384,467 | 79,341 | -305,126 | 0.01 | 0.00 | -0.01 | sell |
| FEDERATED HERMES, INC. | 0 | 77,714 | +77,714 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 98,663 | 74,664 | -23,999 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 0 | 71,815 | +71,815 | 0.00 | 0.56 | +0.56 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 58,835 | 69,826 | +10,991 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 40,000 | 65,955 | +25,955 | 0.30 | 0.82 | +0.52 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,454 | 64,123 | +51,669 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 69,316 | 61,307 | -8,009 | 0.00 | 0.00 | +0.00 | sell |
| Advisory Services Network, LLC | 37,811 | 60,459 | +22,648 | 0.02 | 0.06 | +0.04 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 59,204 | +59,204 | 0.00 | 0.40 | +0.40 | buy |
| JANE STREET GROUP, LLC | 27,581 | 57,256 | +29,675 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 39,553 | 57,004 | +17,451 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 29,788 | 54,988 | +25,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 256,400 | 53,500 | -202,900 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 51,733 | 52,333 | +600 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 48,515 | 49,534 | +1,019 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 35,491 | 48,180 | +12,689 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 39,349 | 47,685 | +8,336 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,929 | 46,777 | +13,848 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 44,160 | 45,656 | +1,496 | 0.18 | 0.33 | +0.15 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 44,604 | 43,004 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 38,250 | 38,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 33,435 | 38,208 | +4,773 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 46,981 | 34,781 | -12,200 | 0.04 | 0.04 | +0.01 | sell |
| FMR LLC | 5,032 | 33,827 | +28,795 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,357 | 32,213 | -13,144 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 29,242 | 30,906 | +1,664 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,033 | 30,033 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 45,600 | 28,178 | -17,422 | 1.01 | 1.17 | +0.16 | sell |
| BLAIR WILLIAM & CO/IL | 0 | 27,230 | +27,230 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,579 | 26,595 | +2,016 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,754 | 25,644 | -110 | 0.00 | 0.00 | +0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 25,075 | 23,175 | -1,900 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 21,504 | 22,678 | +1,174 | 0.00 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 18,105 | 22,113 | +4,008 | 0.03 | 0.05 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,202 | 20,926 | +724 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 20,811 | +20,811 | 0.00 | 0.46 | +0.46 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,300 | 20,300 | +9,000 | 0.22 | 0.75 | +0.53 | buy |
| Janney Montgomery Scott LLC | 21,068 | 18,850 | -2,218 | 0.00 | 0.00 | +0.00 | sell |
| Numerai GP LLC | 0 | 18,668 | +18,668 | 0.00 | 0.28 | +0.28 | buy |
| Corebridge Financial, Inc. | 19,669 | 18,289 | -1,380 | 0.00 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 19,920 | 16,224 | -3,696 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 15,118 | +15,118 | 0.00 | 0.06 | +0.06 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 8,572 | 14,681 | +6,109 | 0.00 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 13,880 | +13,880 | 0.00 | 0.01 | +0.01 | buy |