| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,177,436 | 3,335,320 | +157,884 | 2.33 | 2.74 | +0.41 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,031,041 | 1,172,427 | +141,386 | 0.44 | 0.65 | +0.21 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 103,811 | 173,275 | +69,464 | 0.02 | 0.04 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 452,857 | 518,780 | +65,923 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 267,505 | 332,446 | +64,941 | 100.00 | 0.41 | -99.59 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 100,000 | 161,830 | +61,830 | 0.01 | 0.02 | +0.01 | buy |
| Voleon Capital Management LP | 22,983 | 77,375 | +54,392 | 0.03 | 0.14 | +0.10 | buy |
| LOOMIS SAYLES & CO L P | 389,901 | 441,873 | +51,972 | 0.03 | 0.04 | +0.02 | buy |
| HighVista Strategies LLC | 24,854 | 53,564 | +28,710 | 0.36 | 1.13 | +0.77 | buy |
| Lisanti Capital Growth, LLC | 43,011 | 64,341 | +21,330 | 0.63 | 1.25 | +0.62 | buy |
| ALPS ADVISORS INC | 21,452 | 34,755 | +13,303 | 0.01 | 0.02 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 52,692 | 64,012 | +11,320 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 7,995 | 17,755 | +9,760 | 0.05 | 0.13 | +0.07 | buy |
| Baader Bank Aktiengesellschaft | 5,000 | 12,000 | +7,000 | 0.02 | 0.07 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 15,588 | 21,722 | +6,134 | 0.07 | 0.14 | 0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37,102 | 31,493 | +5,609 | 0.01 | 0.01 | 0.00 | sell |
| Deep Track Capital, LP | 3,000,000 | 3,004,034 | +4,034 | 4.98 | 5.61 | +0.64 | buy |
| Quarry LP | 6,100 | 2,400 | +3,700 | 0.09 | 0.03 | 0.00 | sell |
| AlphaQuest LLC | 15,575 | 19,193 | +3,618 | 0.07 | 0.10 | 0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 8,437 | 11,603 | +3,166 | 0.08 | 0.15 | +0.07 | buy |
| PROFUND ADVISORS LLC | 6,148 | 3,830 | +2,318 | 0.01 | 0.01 | 0.00 | sell |
| KEYBANK NATIONAL ASSOCIATION/OH | 12,383 | 10,705 | +1,678 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 128,737 | 130,380 | +1,643 | 0.01 | 0.02 | 0.00 | buy |
| Valeo Financial Advisors, LLC | 3,523 | 3,915 | +392 | 0.00 | 0.01 | +0.00 | buy |
| 1620 INVESTMENT ADVISORS, INC. | 1,810 | 1,807 | -3 | 0.07 | 0.10 | +0.03 | sell |
| GF FUND MANAGEMENT CO. LTD. | 908 | 833 | -75 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,400 | 6,917 | -483 | 0.04 | 0.04 | +0.01 | sell |
| STRS OHIO | 10,500 | 8,400 | -2,100 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 10,852 | 8,399 | -2,453 | 0.18 | 0.19 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 18,405 | 14,740 | -3,665 | 0.68 | 0.97 | +0.29 | sell |
| Pale Fire Capital SE | 7,075 | 2,452 | -4,623 | 0.05 | 0.03 | -0.02 | sell |
| E. Ohman J:or Asset Management AB | 38,323 | 33,323 | -5,000 | 0.05 | 0.06 | +0.01 | sell |
| MPM BioImpact LLC | 341,496 | 328,869 | -12,627 | 3.32 | 3.08 | -0.24 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 31,500 | 16,800 | -14,700 | 0.41 | 0.33 | -0.07 | sell |
| Rock Springs Capital Management LP | 288,344 | 260,344 | -28,000 | 1.00 | 1.09 | +0.09 | sell |
| J. Goldman & Co LP | 44,300 | 2,699 | -41,601 | 0.07 | 0.01 | -0.06 | sell |
| Ikarian Capital, LLC | 73,619 | 31,166 | -42,453 | 0.89 | 0.33 | -0.55 | sell |
| ORBIMED ADVISORS LLC | 197,900 | 154,400 | -43,500 | 0.28 | 0.26 | -0.02 | sell |
| Integral Health Asset Management, LLC | 250,000 | 200,000 | -50,000 | 1.08 | 0.83 | -0.25 | sell |
| Cormorant Asset Management, LP | 300,000 | 250,000 | -50,000 | 1.23 | 0.95 | -0.28 | sell |
| Clearbridge Investments, LLC | 566,978 | 506,089 | -60,889 | 0.03 | 0.03 | +0.01 | sell |
| Sands Capital Alternatives, LLC | 170,000 | 85,000 | -85,000 | 2.21 | 1.34 | -0.87 | sell |
| Paradigm Biocapital Advisors LP | 2,665,698 | 2,562,154 | -103,544 | 4.69 | 5.62 | +0.93 | sell |
| Artisan Partners Limited Partnership | 558,326 | 436,576 | -121,750 | 0.05 | 0.05 | +0.01 | sell |
| LORD, ABBETT & CO. LLC | 985,629 | 855,645 | -129,984 | 0.17 | 0.21 | +0.04 | sell |
| Capricorn Fund Managers Ltd | 240,020 | 21,982 | -218,038 | 4.79 | 0.43 | -4.36 | sell |
| JENNISON ASSOCIATES LLC | 2,604,580 | 2,230,069 | -374,511 | 0.09 | 0.11 | +0.02 | sell |
| Frazier Life Sciences Management, L.P. | 1,167,527 | 728,644 | -438,883 | 2.08 | 1.60 | -0.48 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,454,797 | 1,188,624 | -1,266,173 | 5.62 | 4.81 | -0.81 | sell |