| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 1,000,000 | 1,400,000 | +400,000 | 1.55 | 2.49 | +0.94 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 855,813 | +355,813 | 2.14 | 3.15 | +1.01 | buy |
| Rhenman & Partners Asset Management AB | 239,500 | 384,800 | +145,300 | 0.55 | 0.71 | +0.16 | buy |
| Granahan Investment Management, LLC | 220,600 | 313,884 | +93,284 | 0.20 | 0.22 | +0.02 | buy |
| J. Goldman & Co LP | 136,900 | 215,945 | +79,045 | 0.07 | 0.11 | +0.03 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 191,760 | 215,652 | +23,892 | 2.52 | 2.93 | +0.40 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 167,766 | 183,801 | +16,035 | 0.17 | 0.17 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,518 | 26,590 | +10,072 | 0.05 | 0.09 | +0.04 | buy |
| CONGRESS ASSET MANAGEMENT CO | 178,555 | 180,448 | +1,893 | 0.02 | 0.02 | -0.00 | buy |
| HighVista Strategies LLC | 193,955 | 187,946 | -6,009 | 1.00 | 0.83 | -0.16 | sell |
| Headlands Technologies LLC | 97,133 | 57,087 | -40,046 | 0.21 | 0.12 | -0.09 | sell |
| Candriam S.C.A. | 818,126 | 769,766 | -48,360 | 0.08 | 0.07 | -0.01 | sell |
| Rock Springs Capital Management LP | 61,700 | 10,696 | -51,004 | 0.07 | 0.01 | -0.06 | sell |
| Voleon Capital Management LP | 373,021 | 173,909 | -199,112 | 0.15 | 0.06 | -0.09 | sell |
| MPM BioImpact LLC | 1,811,082 | 1,606,967 | -204,115 | 2.61 | 1.91 | -0.70 | sell |
| Longaeva Partners L.P. | 410,000 | 161,557 | -248,443 | 0.28 | 0.07 | -0.21 | sell |
| Holocene Advisors, LP | 600,000 | 250,000 | -350,000 | 0.03 | 0.01 | -0.02 | sell |
| Cormorant Asset Management, LP | 4,480,433 | 3,205,433 | -1,275,000 | 4.19 | 3.20 | -1.00 | sell |