| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,525,717 | 2,284,913 | +759,196 | 0.19 | 0.22 | +0.03 | buy |
| Holocene Advisors, LP | 961,330 | 1,454,869 | +493,539 | 0.23 | 0.27 | +0.04 | buy |
| CITADEL ADVISORS LLC | 2,008,660 | 2,309,433 | +300,773 | 0.17 | 0.16 | -0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 612,050 | 910,873 | +298,823 | 0.22 | 0.24 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 82,398 | 339,012 | +256,614 | 0.11 | 0.30 | +0.19 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 598,510 | 424,695 | +173,815 | 0.11 | 0.06 | 0.00 | sell |
| Granahan Investment Management, LLC | 126,772 | 215,816 | +89,044 | 0.25 | 0.38 | +0.13 | buy |
| Woodline Partners LP | 121,754 | 207,415 | +85,661 | 0.08 | 0.10 | +0.02 | buy |
| Candriam S.C.A. | 185,000 | 239,000 | +54,000 | 0.08 | 0.08 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 65,000 | 100,000 | +35,000 | 0.94 | 1.00 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 82,009 | 101,071 | +19,062 | 0.70 | 0.62 | -0.08 | buy |
| SECTORAL ASSET MANAGEMENT INC | 30,005 | 46,295 | +16,290 | 0.78 | 0.91 | +0.13 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 17,236 | 25,126 | +7,890 | 0.00 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 22,781 | 29,093 | +6,312 | 0.17 | 0.10 | -0.07 | buy |
| Affinity Asset Advisors, LLC | 70,988 | 75,000 | +4,012 | 0.85 | 0.61 | -0.24 | buy |
| ALPS ADVISORS INC | 38,897 | 42,273 | +3,376 | 0.02 | 0.02 | -0.00 | buy |
| Pearl River Capital, LLC | 4,292 | 6,750 | +2,458 | 0.04 | 0.05 | +0.01 | buy |
| MPM BioImpact LLC | 294,576 | 296,050 | +1,474 | 4.16 | 2.39 | -1.77 | buy |
| Quarry LP | 850 | 1,100 | +250 | 0.02 | 0.02 | 0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 228,992 | 229,230 | +238 | 3.15 | 1.78 | -1.37 | buy |
| VIRTUS ADVISERS, LLC | 1,605 | 1,504 | -101 | 0.06 | 0.04 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 209,142 | 204,094 | -5,048 | 0.01 | 0.01 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,335 | 26,713 | -8,622 | 0.05 | 0.03 | -0.02 | sell |
| 5AM Venture Management, LLC | 302,630 | 282,313 | -20,317 | 4.85 | 3.18 | -1.67 | sell |
| LORD, ABBETT & CO. LLC | 159,319 | 86,487 | -72,832 | 0.03 | 0.01 | -0.02 | sell |
| STEMPOINT CAPITAL LP | 167,851 | 90,647 | -77,204 | 2.73 | 1.22 | -1.51 | sell |
| Polar Capital Holdings Plc | 937,115 | 857,957 | -79,158 | 0.35 | 0.23 | -0.12 | sell |
| T. Rowe Price Investment Management, Inc. | 1,220,602 | 1,095,101 | -125,501 | 0.05 | 0.03 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 810,586 | 666,722 | -143,864 | 0.26 | 0.17 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,314,012 | 2,135,883 | -178,129 | 0.02 | 0.01 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 488,805 | 209,487 | -279,318 | 0.43 | 0.15 | -0.28 | sell |
| Finepoint Capital LP | 895,000 | 360,916 | -534,084 | 0.02 | 4.65 | +4.63 | sell |