| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 21,751,284 | 21,751,284 | 0 | 32.87 | 30.04 | -2.84 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 24.56 | 18.80 | -5.76 | hold |
| FMR LLC | 3,847,678 | 4,370,652 | +522,974 | 0.02 | 0.01 | -0.00 | buy |
| Avoro Capital Advisors LLC | 2,580,000 | 2,580,000 | 0 | 2.15 | 1.51 | -0.64 | hold |
| CITADEL ADVISORS LLC | 2,008,660 | 2,309,433 | +300,773 | 0.12 | 0.11 | -0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,525,717 | 2,284,913 | +759,196 | 0.19 | 0.22 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,314,012 | 2,135,883 | -178,129 | 0.02 | 0.01 | -0.01 | sell |
| Holocene Advisors, LP | 961,330 | 1,454,869 | +493,539 | 0.23 | 0.27 | +0.04 | buy |
| FEDERATED HERMES, INC. | 1,060,526 | 1,099,756 | +39,230 | 0.16 | 0.13 | -0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 1,220,602 | 1,095,101 | -125,501 | 0.05 | 0.03 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 909,151 | 955,507 | +46,356 | 0.02 | 0.02 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 612,050 | 910,873 | +298,823 | 0.22 | 0.24 | +0.02 | buy |
| Polar Capital Holdings Plc | 937,115 | 857,957 | -79,158 | 0.35 | 0.23 | -0.12 | sell |
| FRED ALGER MANAGEMENT, LLC | 810,586 | 666,722 | -143,864 | 0.26 | 0.17 | -0.10 | sell |
| MARSHALL WACE, LLP | 0 | 510,946 | +510,946 | 0.00 | 0.04 | +0.04 | buy |
| Pictet Asset Management Holding SA | 616,563 | 499,841 | -116,722 | 0.04 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 598,510 | 424,695 | -173,815 | 0.10 | 0.05 | -0.05 | sell |
| Finepoint Capital LP | 895,000 | 360,916 | -534,084 | 0.02 | 4.65 | +4.63 | sell |
| PERCEPTIVE ADVISORS LLC | 82,398 | 339,012 | +256,614 | 0.11 | 0.30 | +0.19 | buy |
| MPM BioImpact LLC | 294,576 | 296,050 | +1,474 | 4.16 | 2.39 | -1.77 | buy |
| 5AM Venture Management, LLC | 302,630 | 282,313 | -20,317 | 4.85 | 3.18 | -1.67 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 257,192 | 276,439 | +19,247 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 185,000 | 239,000 | +54,000 | 0.08 | 0.08 | -0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 228,992 | 229,230 | +238 | 3.15 | 1.78 | -1.37 | buy |
| MORGAN STANLEY | 66,514 | 229,182 | +162,668 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 220,000 | 220,000 | 0 | 1.92 | 1.08 | -0.83 | hold |
| Granahan Investment Management, LLC | 126,772 | 215,816 | +89,044 | 0.25 | 0.38 | +0.13 | buy |
| TimesSquare Capital Management, LLC | 488,805 | 209,487 | -279,318 | 0.43 | 0.15 | -0.28 | sell |
| Woodline Partners LP | 121,754 | 207,415 | +85,661 | 0.08 | 0.10 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 209,142 | 204,094 | -5,048 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 151,134 | 158,160 | +7,026 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 154,607 | 150,645 | -3,962 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 160,400 | 143,450 | -16,950 | 0.08 | 0.06 | -0.02 | sell |
| Walleye Capital LLC | 0 | 136,429 | +136,429 | 0.00 | 0.07 | +0.07 | buy |
| Monashee Investment Management LLC | 0 | 115,000 | +115,000 | 0.00 | 0.68 | +0.68 | buy |
| AXA S.A. | 104,226 | 104,255 | +29 | 0.02 | 0.02 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 82,009 | 101,071 | +19,062 | 0.70 | 0.62 | -0.08 | buy |
| Blue Owl Capital Holdings LP | 65,000 | 100,000 | +35,000 | 0.94 | 1.00 | +0.07 | buy |
| ROYAL BANK OF CANADA | 26,788 | 97,474 | +70,686 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 73,657 | 92,298 | +18,641 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 167,851 | 90,647 | -77,204 | 2.73 | 1.22 | -1.51 | sell |
| JANE STREET GROUP, LLC | 77,949 | 90,169 | +12,220 | 0.01 | 0.01 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 87,500 | +87,500 | 0.00 | 0.12 | +0.12 | buy |
| LORD, ABBETT & CO. LLC | 159,319 | 86,487 | -72,832 | 0.03 | 0.01 | -0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,921 | 82,833 | -1,088 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 70,988 | 75,000 | +4,012 | 0.85 | 0.61 | -0.24 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 214,116 | 72,361 | -141,755 | 0.02 | 0.01 | -0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 73,060 | 63,735 | -9,325 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 59,769 | 59,769 | 0 | 1.31 | 1.07 | -0.24 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 48,774 | 54,026 | +5,252 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 53,648 | 53,187 | -461 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 30,005 | 46,295 | +16,290 | 0.78 | 0.91 | +0.13 | buy |
| STATE STREET CORP | 30,341 | 45,361 | +15,020 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,897 | 42,273 | +3,376 | 0.02 | 0.02 | -0.00 | buy |
| Swiss National Bank | 35,300 | 35,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 15,291 | 31,941 | +16,650 | 0.01 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 30,154 | 31,411 | +1,257 | 0.03 | 0.02 | -0.01 | buy |
| CenterBook Partners LP | 22,781 | 29,093 | +6,312 | 0.17 | 0.10 | -0.07 | buy |
| Clearbridge Investments, LLC | 0 | 28,551 | +28,551 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,335 | 26,713 | -8,622 | 0.05 | 0.03 | -0.02 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 17,236 | 25,126 | +7,890 | 0.00 | 0.01 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 24,541 | +24,541 | 0.00 | 0.64 | +0.64 | buy |
| MILLENNIUM MANAGEMENT LLC | 74,108 | 20,975 | -53,133 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 38,185 | 20,859 | -17,326 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 17,107 | +17,107 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,937 | 16,366 | +429 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,231 | 15,231 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 14,752 | +14,752 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 14,458 | +14,458 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 13,520 | +13,520 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,096 | 13,384 | -1,712 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 10,575 | 12,332 | +1,757 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,300 | 12,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 11,222 | 11,287 | +65 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 9,697 | +9,697 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 9,117 | 8,442 | -675 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 91 | 8,266 | +8,175 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 8,208 | +8,208 | 0.00 | 0.05 | +0.05 | buy |
| Diametric Capital, LP | 0 | 7,696 | +7,696 | 0.00 | 0.21 | +0.21 | buy |
| Pearl River Capital, LLC | 4,292 | 6,750 | +2,458 | 0.04 | 0.05 | +0.01 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,000 | 6,700 | +700 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 7,266 | 6,646 | -620 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 6,488 | 5,858 | -630 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 7,202 | 5,714 | -1,488 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 0 | 5,678 | +5,678 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 18,920 | 5,655 | -13,265 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 5,001 | 4,942 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 0 | 4,400 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 4,213 | +4,213 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 11,000 | 4,149 | -6,851 | 0.06 | 0.01 | -0.04 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,589 | 4,030 | +441 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4,149 | 4,002 | -147 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 6,114 | 3,779 | -2,335 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.04 | +0.04 | buy |
| Belvedere Trading LLC | 0 | 2,201 | +2,201 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 1,605 | 1,504 | -101 | 0.06 | 0.04 | -0.02 | sell |
| Quarry LP | 850 | 1,100 | +250 | 0.03 | 0.02 | -0.00 | buy |
| EntryPoint Capital, LLC | 1,722 | 862 | -860 | 0.10 | 0.04 | -0.06 | sell |
| KBC Group NV | 0 | 565 | +565 | 0.00 | 0.00 | +0.00 | buy |