| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,311,619 | 1,434,770 | +123,151 | 0.31 | 0.27 | -0.04 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 111,133 | 137,516 | +26,383 | 0.33 | 0.32 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 79,648 | 102,020 | +22,372 | 0.19 | 0.18 | 0.00 | buy |
| Hood River Capital Management LLC | 649,590 | 662,983 | +13,393 | 0.52 | 0.44 | -0.08 | buy |
| Granahan Investment Management, LLC | 136,438 | 142,220 | +5,782 | 0.31 | 0.28 | -0.03 | buy |
| Birchview Capital, LP | 4,000 | 8,000 | +4,000 | 0.18 | 0.27 | +0.10 | buy |
| Woodline Partners LP | 293,535 | 296,148 | +2,613 | 0.11 | 0.08 | -0.03 | buy |
| DnB Asset Management AS | 8,356 | 10,311 | +1,955 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 315,230 | 316,049 | +819 | 2.42 | 2.12 | -0.30 | buy |
| J.Safra Asset Management Corp | 8 | 51 | +43 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 72,993 | 72,730 | -263 | 0.03 | 0.02 | -0.01 | sell |
| Bellevue Group AG | 4,400 | 3,000 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 346,111 | 343,849 | -2,262 | 7.34 | 6.78 | -0.56 | sell |
| WEXFORD CAPITAL LP | 24,000 | 21,500 | -2,500 | 0.21 | 0.22 | +0.01 | sell |
| ALPS ADVISORS INC | 50,995 | 47,101 | -3,894 | 0.02 | 0.01 | -0.01 | sell |
| BIT Capital GmbH | 20,748 | 14,610 | -6,138 | 0.09 | 0.05 | -0.04 | sell |
| SECTORAL ASSET MANAGEMENT INC | 23,687 | 15,108 | -8,579 | 0.86 | 0.46 | -0.40 | sell |
| Clearbridge Investments, LLC | 43,380 | 32,612 | -10,768 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 17,424 | 5,424 | -12,000 | 0.19 | 0.04 | -0.15 | sell |
| Finepoint Capital LP | 447,935 | 435,785 | -12,150 | 1.48 | 1.30 | -0.18 | sell |
| FRED ALGER MANAGEMENT, LLC | 673,773 | 642,881 | -30,892 | 0.17 | 0.14 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 261,634 | 216,904 | -44,730 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 227,476 | 174,520 | -52,956 | 0.07 | 0.04 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,343,643 | 2,973,830 | -369,813 | 0.02 | 0.01 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 1,772,211 | 627,423 | -1,144,788 | 3.34 | 1.13 | -2.21 | sell |
| Holocene Advisors, LP | 1,585,167 | 188,989 | -1,396,178 | 0.27 | 0.02 | -0.25 | sell |