| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 2.43 | +2.43 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 344,320 | +344,320 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 296,000 | +296,000 | 0.00 | 1.58 | +1.58 | buy |
| Octagon Capital Advisors LP | 0 | 250,000 | +250,000 | 0.00 | 0.39 | +0.39 | buy |
| Vestal Point Capital, LP | 0 | 200,000 | +200,000 | 0.00 | 0.56 | +0.56 | buy |
| FRANKLIN RESOURCES INC | 0 | 191,500 | +191,500 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 179,196 | +179,196 | 0.00 | 1.41 | +1.41 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,311,619 | 1,434,770 | +123,151 | 0.31 | 0.27 | -0.04 | buy |
| Catalio Capital Management, LP | 0 | 114,616 | +114,616 | 0.00 | 1.11 | +1.11 | buy |
| UBS Group AG | 27,918 | 120,769 | +92,851 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 178,501 | 258,150 | +79,649 | 0.01 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 7,500 | 80,000 | +72,500 | 0.00 | 0.02 | +0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 55,245 | +55,245 | 0.00 | 0.45 | +0.45 | buy |
| Nicholas Investment Partners, LP | 0 | 46,933 | +46,933 | 0.00 | 0.19 | +0.19 | buy |
| BANK OF AMERICA CORP /DE/ | 45,540 | 91,174 | +45,634 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 45,000 | +45,000 | 0.00 | 0.20 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 35,638 | +35,638 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 32,145 | +32,145 | 0.00 | 1.50 | +1.50 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,592 | +31,592 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 27,489 | +27,489 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 111,133 | 137,516 | +26,383 | 0.33 | 0.32 | -0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 25,400 | +25,400 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 25,000 | +25,000 | 0.00 | 0.04 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,819 | +24,819 | 0.00 | 0.01 | +0.01 | buy |
| Zimmer Partners, LP | 0 | 24,500 | +24,500 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 24,317 | +24,317 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 79,648 | 102,020 | +22,372 | 0.19 | 0.18 | -0.01 | buy |
| CITIGROUP INC | 1,212 | 21,228 | +20,016 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 16,942 | +16,942 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 4,646 | 19,599 | +14,953 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 14,664 | +14,664 | 0.00 | 0.02 | +0.02 | buy |
| Hood River Capital Management LLC | 649,590 | 662,983 | +13,393 | 0.52 | 0.44 | -0.08 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 9,510 | +9,510 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 8,495 | +8,495 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 47,144 | 54,331 | +7,187 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,992 | +6,992 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 3,911 | 10,669 | +6,758 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 136,438 | 142,220 | +5,782 | 0.31 | 0.28 | -0.03 | buy |
| SEI INVESTMENTS CO | 22,025 | 27,388 | +5,363 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 8,971 | 14,225 | +5,254 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 4,000 | 8,000 | +4,000 | 0.18 | 0.27 | +0.10 | buy |
| Jefferies Financial Group Inc. | 6,250 | 10,000 | +3,750 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,050 | +3,050 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 293,535 | 296,148 | +2,613 | 0.11 | 0.08 | -0.03 | buy |
| Quarry LP | 0 | 2,400 | +2,400 | 0.00 | 0.02 | +0.02 | buy |
| DnB Asset Management AS | 8,356 | 10,311 | +1,955 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 91,545 | 93,397 | +1,852 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 2,206 | 4,009 | +1,803 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 42,236 | 43,804 | +1,568 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 1,030 | 2,208 | +1,178 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 315,230 | 316,049 | +819 | 2.42 | 2.12 | -0.30 | buy |
| LPL Financial LLC | 8,146 | 8,847 | +701 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,500 | 9,200 | +700 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 146 | +146 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 82 | +82 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 14,261 | 14,331 | +70 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,950 | 58,994 | +44 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 8 | 51 | +43 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 25 | 49 | +24 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 19,751,284 | 19,751,284 | 0 | 36.25 | 31.45 | -4.80 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,972 | 18,972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRIVATE TRUST CO NA | 193 | 193 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Amundi | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 43,541 | 43,541 | 0 | 0.88 | 0.66 | -0.22 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,753 | 2,753 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 11,100 | 11,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Camber Capital Management LP | 441,000 | 441,000 | 0 | 0.93 | 1.08 | +0.14 | hold |
| Ensign Peak Advisors, Inc | 9,139 | 9,139 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allianz Asset Management GmbH | 9,900 | 9,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 43,000 | 43,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 25.26 | 25.13 | -0.13 | hold |
| Avoro Capital Advisors LLC | 2,770,100 | 2,770,100 | 0 | 2.12 | 1.69 | -0.43 | hold |
| KLP KAPITALFORVALTNING AS | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 200,000 | 200,000 | 0 | 0.96 | 0.87 | -0.09 | hold |
| 5AM Venture Management, LLC | 282,313 | 282,313 | 0 | 3.65 | 4.17 | +0.52 | hold |
| Polar Capital Holdings Plc | 1,100,000 | 1,100,000 | 0 | 0.33 | 0.26 | -0.07 | hold |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 85 | 85 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 19,480 | 19,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 903 | 903 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,865 | 12,858 | -7 | 0.00 | 0.00 | -0.00 | sell |
| Geneos Wealth Management Inc. | 14 | 6 | -8 | 0.00 | 0.00 | +0.00 | sell |
| Arizona State Retirement System | 6,371 | 6,332 | -39 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 78 | 0 | -78 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 104,178 | 104,044 | -134 | 0.02 | 0.01 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 72,993 | 72,730 | -263 | 0.03 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 15,895 | 15,554 | -341 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6,532 | 5,940 | -592 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,250 | 0 | -1,250 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,633 | 6,328 | -1,305 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,322 | 0 | -1,322 | 0.03 | 0.00 | -0.03 | sell |
| VANGUARD GROUP INC | 115,416 | 114,018 | -1,398 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 4,400 | 3,000 | -1,400 | 0.00 | 0.00 | -0.00 | sell |