| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,751,284 | 16,001,284 | -3,750,000 | 8.76 | 9.50 | +0.74 | sell |
| Deep Track Capital, LP | 4,610,071 | 6,408,863 | +1,798,792 | 1.39 | 2.47 | +1.08 | buy |
| Cormorant Asset Management, LP | 4,355,433 | 4,480,433 | +125,000 | 3.25 | 4.21 | +0.96 | buy |
| JANUS HENDERSON GROUP PLC | 2,095,988 | 3,451,628 | +1,355,640 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 2,480,767 | 2,390,661 | -90,106 | 0.02 | 0.04 | +0.01 | sell |
| MPM BioImpact LLC | 0 | 1,811,082 | +1,811,082 | 0.00 | 2.61 | +2.61 | buy |
| Weiss Asset Management LP | 332,961 | 1,708,328 | +1,375,367 | 0.06 | 0.58 | +0.52 | buy |
| Logos Global Management LP | 1,750,000 | 1,500,000 | -250,000 | 1.54 | 1.44 | -0.10 | sell |
| Point72 Asset Management, L.P. | 772,500 | 1,368,518 | +596,018 | 0.02 | 0.04 | +0.03 | buy |
| CITADEL ADVISORS LLC | 380,890 | 1,323,728 | +942,838 | 0.00 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 959,553 | 1,294,861 | +335,308 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 270,665 | 1,130,233 | +859,568 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 784,811 | 1,122,312 | +337,501 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 837,739 | 1,088,514 | +250,775 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,571,071 | 1,065,610 | -505,461 | 0.04 | 0.04 | +0.00 | sell |
| BlackRock, Inc. | 286,593 | 1,021,851 | +735,258 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 1,000,000 | 1,000,000 | 0 | 0.85 | 1.55 | +0.70 | hold |
| Candriam S.C.A. | 134,329 | 818,126 | +683,797 | 0.01 | 0.08 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 724,794 | +724,794 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,044,581 | 614,482 | -430,099 | 0.00 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 0 | 600,000 | +600,000 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 802,722 | 576,092 | -226,630 | 0.01 | 0.01 | +0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 500,000 | +500,000 | 0.00 | 2.28 | +2.28 | buy |
| Jefferies Financial Group Inc. | 500,000 | 500,000 | 0 | 0.05 | 0.11 | +0.06 | hold |
| Trexquant Investment LP | 184,319 | 495,336 | +311,017 | 0.02 | 0.07 | +0.05 | buy |
| HRT FINANCIAL LP | 635,901 | 487,583 | -148,318 | 0.03 | 0.02 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 457,137 | +457,137 | 0.00 | 0.51 | +0.51 | buy |
| JANE STREET GROUP, LLC | 1,682,148 | 453,625 | -1,228,523 | 0.03 | 0.01 | -0.02 | sell |
| Casdin Capital, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.64 | +0.64 | buy |
| Longaeva Partners L.P. | 0 | 410,000 | +410,000 | 0.00 | 0.37 | +0.37 | buy |
| Voleon Capital Management LP | 499,099 | 373,021 | -126,078 | 0.14 | 0.15 | +0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549,236 | 341,424 | -207,812 | 0.01 | 0.01 | -0.00 | sell |
| Jump Financial, LLC | 425,559 | 325,968 | -99,591 | 0.07 | 0.09 | +0.02 | sell |
| Walleye Capital LLC | 75,752 | 320,472 | +244,720 | 0.01 | 0.04 | +0.03 | buy |
| First Turn Management, LLC | 262,643 | 315,563 | +52,920 | 0.40 | 0.66 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 134,472 | 276,772 | +142,300 | 0.00 | 0.01 | +0.01 | buy |
| Boxer Capital Management, LLC | 275,000 | 275,000 | 0 | 0.79 | 0.67 | -0.12 | hold |
| Susquehanna Portfolio Strategies, LLC | 253,974 | 253,974 | 0 | 0.05 | 0.07 | +0.02 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 11,310 | 239,838 | +228,528 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 364,000 | 239,500 | -124,500 | 0.45 | 0.55 | +0.10 | sell |
| Granahan Investment Management, LLC | 198,307 | 220,600 | +22,293 | 0.11 | 0.20 | +0.09 | buy |
| Exome Asset Management LLC | 0 | 215,376 | +215,376 | 0.00 | 2.36 | +2.36 | buy |
| HighVista Strategies LLC | 0 | 193,955 | +193,955 | 0.00 | 1.00 | +1.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 59,280 | 191,760 | +132,480 | 0.53 | 2.54 | +2.01 | buy |
| CONGRESS ASSET MANAGEMENT CO | 71,096 | 178,555 | +107,459 | 0.01 | 0.02 | +0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 127,465 | 167,766 | +40,301 | 0.09 | 0.17 | +0.08 | buy |
| ALGERT GLOBAL LLC | 221,616 | 151,256 | -70,360 | 0.05 | 0.04 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 144,238 | +144,238 | 0.00 | 0.16 | +0.16 | buy |
| FMR LLC | 156,276 | 143,559 | -12,717 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 126,744 | 142,706 | +15,962 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 139,574 | +139,574 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 101,467 | 136,900 | +35,433 | 0.05 | 0.12 | +0.07 | buy |
| Y-Intercept (Hong Kong) Ltd | 95,972 | 127,087 | +31,115 | 0.03 | 0.04 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 212,996 | 120,310 | -92,686 | 0.03 | 0.02 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85,570 | 118,961 | +33,391 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 22,973 | 112,044 | +89,071 | 0.01 | 0.04 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 111,331 | +111,331 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 121,640 | 110,217 | -11,423 | 0.00 | 0.00 | +0.00 | sell |
| Headlands Technologies LLC | 0 | 97,133 | +97,133 | 0.00 | 0.21 | +0.21 | buy |
| GSA CAPITAL PARTNERS LLP | 89,236 | 80,233 | -9,003 | 0.10 | 0.09 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 74,162 | +74,162 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 72,606 | 72,269 | -337 | 0.00 | 0.00 | +0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 70,140 | +70,140 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 67,500 | 67,500 | 0 | 4.60 | 7.52 | +2.92 | hold |
| Rock Springs Capital Management LP | 61,700 | 61,700 | 0 | 0.04 | 0.07 | +0.03 | hold |
| TUDOR INVESTMENT CORP ET AL | 103,516 | 61,577 | -41,939 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 61,500 | 61,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 58,169 | 58,395 | +226 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 50,973 | 56,490 | +5,517 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.19 | +0.19 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 48,883 | +48,883 | 0.00 | 0.07 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 32,886 | 46,185 | +13,299 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 20,159 | 44,950 | +24,791 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 42,917 | +42,917 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 637,434 | 33,417 | -604,017 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 78,638 | 32,507 | -46,131 | 0.02 | 0.01 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,296 | 29,296 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 322,261 | 28,682 | -293,579 | 0.02 | 0.00 | -0.02 | sell |
| BARCLAYS PLC | 50,251 | 27,602 | -22,649 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 183,552 | 26,307 | -157,245 | 0.00 | 0.00 | -0.00 | sell |
| Optimize Financial Inc | 0 | 24,419 | +24,419 | 0.00 | 0.22 | +0.22 | buy |
| HRT FINANCIAL LP | 0 | 22,300 | +22,300 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 30,476 | 21,563 | -8,913 | 0.01 | 0.01 | +0.00 | sell |
| Quarry LP | 0 | 21,250 | +21,250 | 0.00 | 0.08 | +0.08 | buy |
| Graham Capital Management, L.P. | 24,292 | 21,089 | -3,203 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 16,078 | 20,559 | +4,481 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 18,479 | 19,477 | +998 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 19,241 | +19,241 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,592 | 19,229 | +5,637 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 17,987 | 18,436 | +449 | 0.06 | 0.09 | +0.03 | buy |
| Vident Advisory, LLC | 15,444 | 18,208 | +2,764 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 16,527 | +16,527 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 71,962 | 16,518 | -55,444 | 0.15 | 0.05 | -0.10 | sell |
| OSAIC HOLDINGS, INC. | 8,985 | 15,905 | +6,920 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 15,670 | +15,670 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 70,611 | 15,362 | -55,249 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 910 | 13,691 | +12,781 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,438 | 12,598 | +160 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,000 | 12,520 | +2,520 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 30,300 | 11,854 | -18,446 | 0.02 | 0.01 | -0.01 | sell |