| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,135,883 | 2,561,512 | +425,629 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 910,873 | 1,117,625 | +206,752 | 0.24 | 0.24 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,580,000 | 2,770,000 | +190,000 | 1.51 | 1.62 | +0.11 | buy |
| Holocene Advisors, LP | 1,454,869 | 1,626,341 | +171,472 | 0.27 | 0.30 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 424,695 | 584,263 | +159,568 | 0.06 | 0.07 | 0.00 | buy |
| Granahan Investment Management, LLC | 215,816 | 283,649 | +67,833 | 0.38 | 0.50 | +0.12 | buy |
| MPM BioImpact LLC | 296,050 | 343,235 | +47,185 | 2.39 | 2.35 | -0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 8,208 | 38,689 | +30,481 | 0.05 | 0.13 | +0.08 | buy |
| Finepoint Capital LP | 360,916 | 388,835 | +27,919 | 4.65 | 4.85 | +0.20 | buy |
| Woodline Partners LP | 207,415 | 226,717 | +19,302 | 0.10 | 0.10 | -0.00 | buy |
| ALPS ADVISORS INC | 42,273 | 49,042 | +6,769 | 0.02 | 0.01 | -0.00 | buy |
| Cinctive Capital Management LP | 4,213 | 10,181 | +5,968 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 204,094 | 209,234 | +5,140 | 0.01 | 0.01 | -0.00 | buy |
| Quarry LP | 1,100 | 3,000 | +1,900 | 0.02 | 0.06 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 3,000 | 4,800 | +1,800 | 0.04 | 0.04 | +0.00 | buy |
| DnB Asset Management AS | 5,678 | 7,372 | +1,694 | 0.00 | 0.00 | +0.00 | buy |
| Pearl River Capital, LLC | 6,750 | 8,067 | +1,317 | 0.05 | 0.06 | +0.00 | buy |
| J. Goldman & Co LP | 17,107 | 18,167 | +1,060 | 0.03 | 0.02 | -0.01 | buy |
| Belvedere Trading LLC | 2,201 | 2,860 | +659 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,504 | 2,120 | +616 | 0.04 | 0.05 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 101,071 | 101,224 | +153 | 0.62 | 0.61 | -0.02 | buy |
| Clearbridge Investments, LLC | 28,551 | 28,536 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 229,230 | 228,803 | -427 | 1.78 | 1.64 | -0.14 | sell |
| TimesSquare Capital Management, LLC | 209,487 | 203,737 | -5,750 | 0.15 | 0.14 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 666,722 | 659,029 | -7,693 | 0.17 | 0.14 | -0.03 | sell |
| CenterBook Partners LP | 29,093 | 15,360 | -13,733 | 0.10 | 0.04 | -0.06 | sell |
| HighVista Strategies LLC | 59,769 | 42,249 | -17,520 | 1.07 | 0.68 | -0.39 | sell |
| SECTORAL ASSET MANAGEMENT INC | 46,295 | 21,428 | -24,867 | 0.91 | 0.38 | -0.53 | sell |
| CITADEL ADVISORS LLC | 2,309,433 | 2,265,695 | -43,738 | 0.16 | 0.14 | -0.02 | sell |
| Monashee Investment Management LLC | 115,000 | 50,000 | -65,000 | 0.68 | 0.28 | -0.40 | sell |
| Polar Capital Holdings Plc | 857,957 | 678,169 | -179,788 | 0.23 | 0.18 | -0.05 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,284,913 | 1,825,000 | -459,913 | 0.22 | 0.15 | -0.07 | sell |