| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 21,751,284 | 21,751,284 | 0 | 30.04 | 26.81 | -3.23 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 18.80 | 21.72 | +2.92 | hold |
| FMR LLC | 4,370,652 | 3,644,009 | -726,643 | 0.01 | 0.01 | -0.00 | sell |
| Avoro Capital Advisors LLC | 2,580,000 | 2,770,000 | +190,000 | 1.51 | 1.62 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,135,883 | 2,561,512 | +425,629 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,309,433 | 2,265,695 | -43,738 | 0.11 | 0.10 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,284,913 | 1,825,000 | -459,913 | 0.22 | 0.15 | -0.07 | sell |
| Holocene Advisors, LP | 1,454,869 | 1,626,341 | +171,472 | 0.27 | 0.30 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 158,160 | 1,251,747 | +1,093,587 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 1,099,756 | 1,128,428 | +28,672 | 0.13 | 0.12 | -0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 910,873 | 1,117,625 | +206,752 | 0.24 | 0.24 | +0.00 | buy |
| MARSHALL WACE, LLP | 510,946 | 1,098,630 | +587,684 | 0.04 | 0.07 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 955,507 | 1,021,750 | +66,243 | 0.02 | 0.02 | -0.00 | buy |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 3.80 | +3.80 | buy |
| Polar Capital Holdings Plc | 857,957 | 678,169 | -179,788 | 0.23 | 0.18 | -0.05 | sell |
| FRED ALGER MANAGEMENT, LLC | 666,722 | 659,029 | -7,693 | 0.17 | 0.14 | -0.03 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 424,695 | 584,263 | +159,568 | 0.05 | 0.07 | +0.01 | buy |
| Finepoint Capital LP | 360,916 | 388,835 | +27,919 | 4.65 | 4.85 | +0.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 276,439 | 372,657 | +96,218 | 0.00 | 0.00 | +0.00 | buy |
| Camber Capital Management LP | 0 | 355,000 | +355,000 | 0.00 | 0.60 | +0.60 | buy |
| Pictet Asset Management Holding SA | 499,841 | 345,840 | -154,001 | 0.03 | 0.02 | -0.01 | sell |
| MPM BioImpact LLC | 296,050 | 343,235 | +47,185 | 2.39 | 2.35 | -0.05 | buy |
| Granahan Investment Management, LLC | 215,816 | 283,649 | +67,833 | 0.38 | 0.50 | +0.12 | buy |
| 5AM Venture Management, LLC | 282,313 | 282,313 | 0 | 3.18 | 2.78 | -0.40 | hold |
| Candriam S.C.A. | 239,000 | 239,000 | 0 | 0.08 | 0.06 | -0.01 | hold |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 229,230 | 228,803 | -427 | 1.78 | 1.64 | -0.14 | sell |
| Woodline Partners LP | 207,415 | 226,717 | +19,302 | 0.10 | 0.10 | -0.00 | buy |
| Integral Health Asset Management, LLC | 220,000 | 220,000 | 0 | 1.08 | 0.96 | -0.12 | hold |
| MILLENNIUM MANAGEMENT LLC | 20,975 | 216,964 | +195,989 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 204,094 | 209,234 | +5,140 | 0.01 | 0.01 | -0.00 | buy |
| TimesSquare Capital Management, LLC | 209,487 | 203,737 | -5,750 | 0.15 | 0.14 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 150,645 | 174,682 | +24,037 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 143,450 | 116,438 | -27,012 | 0.06 | 0.04 | -0.02 | sell |
| Altium Capital Management LLC | 0 | 115,000 | +115,000 | 0.00 | 2.09 | +2.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,833 | 114,234 | +31,401 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 104,255 | 104,314 | +59 | 0.02 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 101,071 | 101,224 | +153 | 0.62 | 0.61 | -0.02 | buy |
| VANGUARD GROUP INC | 92,298 | 91,840 | -458 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 136,429 | 86,278 | -50,151 | 0.07 | 0.04 | -0.03 | sell |
| Eversept Partners, LP | 0 | 71,596 | +71,596 | 0.00 | 0.24 | +0.24 | buy |
| MORGAN STANLEY | 229,182 | 69,027 | -160,155 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 0 | 58,552 | +58,552 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 54,026 | 58,500 | +4,474 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 63,735 | 58,245 | -5,490 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 20,859 | 54,036 | +33,177 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 53,187 | 53,187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Monashee Investment Management LLC | 115,000 | 50,000 | -65,000 | 0.68 | 0.28 | -0.40 | sell |
| ALPS ADVISORS INC | 42,273 | 49,042 | +6,769 | 0.02 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 45,361 | 44,657 | -704 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 59,769 | 42,249 | -17,520 | 1.07 | 0.68 | -0.39 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 8,208 | 38,689 | +30,481 | 0.05 | 0.13 | +0.08 | buy |
| Russell Investments Group, Ltd. | 0 | 33,559 | +33,559 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 90,169 | 32,224 | -57,945 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 35,300 | 30,900 | -4,400 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 29,243 | +29,243 | 0.00 | 0.01 | +0.01 | buy |
| Clearbridge Investments, LLC | 28,551 | 28,536 | -15 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 31,411 | 27,173 | -4,238 | 0.02 | 0.01 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 21,724 | +21,724 | 0.00 | 0.07 | +0.07 | buy |
| SECTORAL ASSET MANAGEMENT INC | 46,295 | 21,428 | -24,867 | 0.91 | 0.38 | -0.53 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,231 | 18,234 | +3,003 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 17,107 | 18,167 | +1,060 | 0.04 | 0.03 | -0.01 | buy |
| ROYAL BANK OF CANADA | 97,474 | 17,836 | -79,638 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 0 | 17,708 | +17,708 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,361 | 16,964 | -55,397 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 15,900 | +15,900 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 0 | 15,790 | +15,790 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 29,093 | 15,360 | -13,733 | 0.10 | 0.04 | -0.06 | sell |
| Hudson Bay Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,366 | 14,244 | -2,122 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 0 | 14,000 | +14,000 | 0.00 | 0.16 | +0.16 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,078 | +13,078 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,384 | 12,556 | -828 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 12,300 | 12,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 12,269 | +12,269 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 11,287 | 11,100 | -187 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 4,213 | 10,181 | +5,968 | 0.01 | 0.02 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 8,442 | 8,146 | -296 | 0.00 | 0.00 | -0.00 | sell |
| Pearl River Capital, LLC | 6,750 | 8,067 | +1,317 | 0.05 | 0.06 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,700 | 8,000 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 25,126 | 7,409 | -17,717 | 0.01 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 5,678 | 7,372 | +1,694 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 7,340 | +7,340 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 13,520 | 6,832 | -6,688 | 0.02 | 0.01 | -0.01 | sell |
| LPL Financial LLC | 6,646 | 6,495 | -151 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 5,714 | 4,877 | -837 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 3,000 | 4,800 | +1,800 | 0.04 | 0.04 | +0.00 | buy |
| Bellevue Group AG | 4,400 | 4,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 14,752 | 3,267 | -11,485 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 1,100 | 3,000 | +1,900 | 0.02 | 0.05 | +0.03 | buy |
| Belvedere Trading LLC | 2,201 | 2,860 | +659 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,030 | 2,753 | -1,277 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,504 | 2,120 | +616 | 0.04 | 0.05 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,118 | +2,118 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 565 | 565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 3,779 | 412 | -3,367 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,266 | 140 | -8,126 | 0.00 | 0.00 | -0.00 | sell |
| PRIVATE TRUST CO NA | 122 | 122 | 0 | 0.00 | 0.00 | -0.00 | hold |