| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 2,770,100 | 4,150,000 | +1,379,900 | 1.69 | 3.43 | +1.74 | buy |
| Vestal Point Capital, LP | 200,000 | 550,000 | +350,000 | 0.56 | 1.37 | +0.81 | buy |
| Paradigm Biocapital Advisors LP | 627,423 | 878,323 | +250,900 | 1.13 | 1.77 | +0.64 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 102,020 | 51,409 | +50,611 | 0.18 | 0.10 | 0.00 | sell |
| Catalio Capital Management, LP | 114,616 | 162,596 | +47,980 | 1.11 | 1.61 | +0.50 | buy |
| ADAR1 Capital Management, LLC | 5,424 | 34,314 | +28,890 | 0.04 | 0.26 | +0.22 | buy |
| Woodline Partners LP | 296,148 | 310,602 | +14,454 | 0.08 | 0.08 | +0.00 | buy |
| ALPS ADVISORS INC | 47,101 | 34,290 | +12,811 | 0.01 | 0.01 | 0.00 | sell |
| Hood River Capital Management LLC | 662,983 | 675,445 | +12,462 | 0.44 | 0.45 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 137,516 | 142,320 | +4,804 | 0.32 | 0.36 | +0.05 | buy |
| Quarry LP | 2,400 | 1,800 | +600 | 0.02 | 0.02 | 0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 72,730 | 72,851 | +121 | 0.02 | 0.02 | +0.00 | buy |
| DnB Asset Management AS | 10,311 | 9,585 | -726 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 55,245 | 54,416 | -829 | 0.45 | 0.50 | +0.05 | sell |
| Virtus Investment Advisers, LLC | 3,050 | 2,136 | -914 | 0.03 | 0.03 | +0.00 | sell |
| MPM BioImpact LLC | 316,049 | 313,571 | -2,478 | 2.12 | 2.56 | +0.44 | sell |
| Clearbridge Investments, LLC | 32,612 | 28,427 | -4,185 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 32,145 | 17,623 | -14,522 | 1.50 | 1.04 | -0.46 | sell |
| Zimmer Partners, LP | 24,500 | 6,960 | -17,540 | 0.02 | 0.01 | -0.01 | sell |
| HighVista Strategies LLC | 43,541 | 20,953 | -22,588 | 0.66 | 0.36 | -0.29 | sell |
| Candriam S.C.A. | 174,520 | 144,830 | -29,690 | 0.04 | 0.04 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 216,904 | 186,152 | -30,752 | 0.01 | 0.01 | -0.00 | sell |
| Saturn V Capital Management LP | 343,849 | 290,784 | -53,065 | 6.78 | 5.56 | -1.22 | sell |
| Granahan Investment Management, LLC | 142,220 | 80,362 | -61,858 | 0.28 | 0.15 | -0.12 | sell |
| Octagon Capital Advisors LP | 296,000 | 148,000 | -148,000 | 2.28 | 1.53 | -0.74 | sell |
| Logos Global Management LP | 350,000 | 200,000 | -150,000 | 2.43 | 1.26 | -1.17 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,434,770 | 1,259,376 | -175,394 | 0.27 | 0.25 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 642,881 | 295,623 | -347,258 | 0.14 | 0.06 | -0.08 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,973,830 | 2,613,233 | -360,597 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 1,100,000 | 247,500 | -852,500 | 0.26 | 0.06 | -0.20 | sell |