| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,751,284 | 19,751,284 | 0 | 31.45 | 33.31 | +1.85 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 25.13 | 29.86 | +4.74 | hold |
| FMR LLC | 6,327,014 | 5,730,549 | -596,465 | 0.02 | 0.02 | -0.00 | sell |
| Avoro Capital Advisors LLC | 2,770,100 | 4,150,000 | +1,379,900 | 1.69 | 3.43 | +1.74 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,973,830 | 2,613,233 | -360,597 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,478,635 | 1,674,041 | +195,406 | 0.06 | 0.07 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,292,608 | 1,275,569 | -17,039 | 0.01 | 0.01 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,434,770 | 1,259,376 | -175,394 | 0.27 | 0.25 | -0.02 | sell |
| FEDERATED HERMES, INC. | 1,269,351 | 1,248,573 | -20,778 | 0.11 | 0.11 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 966,090 | 1,138,022 | +171,932 | 0.01 | 0.02 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 627,423 | 878,323 | +250,900 | 1.13 | 1.77 | +0.64 | buy |
| Nuveen, LLC | 673,343 | 791,555 | +118,212 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 741,090 | +741,090 | 0.00 | 0.50 | +0.50 | buy |
| Hood River Capital Management LLC | 662,983 | 675,445 | +12,462 | 0.44 | 0.45 | +0.00 | buy |
| Vestal Point Capital, LP | 200,000 | 550,000 | +350,000 | 0.56 | 1.37 | +0.81 | buy |
| MARSHALL WACE, LLP | 640,917 | 529,211 | -111,706 | 0.03 | 0.03 | -0.00 | sell |
| Siren, L.L.C. | 0 | 508,267 | +508,267 | 0.00 | 1.24 | +1.24 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 78,835 | 423,170 | +344,335 | 0.01 | 0.05 | +0.04 | buy |
| BlackRock, Inc. | 286,209 | 327,342 | +41,133 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 316,049 | 313,571 | -2,478 | 2.12 | 2.56 | +0.44 | sell |
| Woodline Partners LP | 296,148 | 310,602 | +14,454 | 0.08 | 0.08 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 642,881 | 295,623 | -347,258 | 0.14 | 0.06 | -0.08 | sell |
| Saturn V Capital Management LP | 343,849 | 290,784 | -53,065 | 6.78 | 5.56 | -1.22 | sell |
| 5AM Venture Management, LLC | 282,313 | 282,313 | 0 | 4.17 | 5.12 | +0.95 | hold |
| Polar Capital Holdings Plc | 1,100,000 | 247,500 | -852,500 | 0.26 | 0.06 | -0.20 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 392,924 | 246,114 | -146,810 | 0.02 | 0.01 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 201,521 | 200,321 | -1,200 | 0.00 | 0.00 | +0.00 | sell |
| Integral Health Asset Management, LLC | 200,000 | 200,000 | 0 | 0.87 | 0.88 | +0.02 | hold |
| Logos Global Management LP | 350,000 | 200,000 | -150,000 | 2.43 | 1.26 | -1.17 | sell |
| Point72 Asset Management, L.P. | 0 | 186,568 | +186,568 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 216,904 | 186,152 | -30,752 | 0.01 | 0.01 | -0.00 | sell |
| Catalio Capital Management, LP | 114,616 | 162,596 | +47,980 | 1.11 | 1.61 | +0.50 | buy |
| Octagon Capital Advisors LP | 250,000 | 148,000 | -102,000 | 0.39 | 1.53 | +1.15 | sell |
| Pictet Asset Management Holding SA | 322,114 | 147,721 | -174,393 | 0.01 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 174,520 | 144,830 | -29,690 | 0.04 | 0.04 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 137,516 | 142,320 | +4,804 | 0.32 | 0.36 | +0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 258,150 | 138,368 | -119,782 | 0.01 | 0.00 | -0.01 | sell |
| VANGUARD GROUP INC | 114,018 | 120,869 | +6,851 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 124,904 | 109,969 | -14,935 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 80,000 | 105,000 | +25,000 | 0.02 | 0.03 | +0.01 | buy |
| AXA S.A. | 104,044 | 83,839 | -20,205 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 82,023 | +82,023 | 0.00 | 0.79 | +0.79 | buy |
| Granahan Investment Management, LLC | 142,220 | 80,362 | -61,858 | 0.28 | 0.15 | -0.12 | sell |
| UBS Group AG | 120,769 | 80,350 | -40,419 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 72,730 | 72,851 | +121 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 93,397 | 64,564 | -28,833 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 62,318 | +62,318 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,994 | 59,553 | +559 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 55,245 | 54,416 | -829 | 0.45 | 0.50 | +0.05 | sell |
| DIMENSIONAL FUND ADVISORS LP | 53,494 | 52,719 | -775 | 0.00 | 0.00 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 102,020 | 51,409 | -50,611 | 0.18 | 0.10 | -0.08 | sell |
| Rhenman & Partners Asset Management AB | 45,000 | 45,000 | 0 | 0.20 | 0.27 | +0.07 | hold |
| MORGAN STANLEY | 54,331 | 43,239 | -11,092 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 43,000 | 42,300 | -700 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 0 | 39,397 | +39,397 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 39,000 | +39,000 | 0.00 | 0.37 | +0.37 | buy |
| Cubist Systematic Strategies, LLC | 24,819 | 38,204 | +13,385 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 5,424 | 34,314 | +28,890 | 0.04 | 0.26 | +0.22 | buy |
| ALPS ADVISORS INC | 47,101 | 34,290 | -12,811 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 31,592 | 31,714 | +122 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 27,388 | 29,662 | +2,274 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 32,612 | 28,427 | -4,185 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 25,313 | +25,313 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 24,317 | 23,527 | -790 | 0.01 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 15,554 | 21,857 | +6,303 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 32,163 | 21,390 | -10,773 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 43,541 | 20,953 | -22,588 | 0.66 | 0.36 | -0.29 | sell |
| Legal & General Group Plc | 19,480 | 20,905 | +1,425 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 19,390 | +19,390 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,804 | 19,164 | -24,640 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,972 | 18,972 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 32,145 | 17,623 | -14,522 | 1.50 | 1.04 | -0.46 | sell |
| Squarepoint Ops LLC | 16,942 | 17,571 | +629 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 82 | 17,326 | +17,244 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,933 | 15,752 | +1,819 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 15,108 | 15,108 | 0 | 0.46 | 0.47 | +0.01 | hold |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 14,331 | 14,314 | -17 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,858 | 12,949 | +91 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14,790 | 12,790 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 0 | 12,565 | +12,565 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,225 | 11,949 | -2,276 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 11,100 | 10,600 | -500 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 10,311 | 9,585 | -726 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 9,139 | 9,139 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 8,000 | 8,000 | 0 | 0.27 | 0.37 | +0.10 | hold |
| Zimmer Partners, LP | 24,500 | 6,960 | -17,540 | 0.02 | 0.01 | -0.01 | sell |
| Arizona State Retirement System | 6,332 | 6,428 | +96 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 8,847 | 6,338 | -2,509 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,328 | 6,138 | -190 | 0.00 | 0.00 | +0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5,940 | 5,971 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 5,969 | +5,969 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 5,460 | 5,460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 10,000 | 5,189 | -4,811 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,599 | 4,553 | -15,046 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 4,500 | 4,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,200 | 4,340 | -4,860 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Asset Management, Inc. | 4,009 | 4,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bellevue Group AG | 3,000 | 3,000 | 0 | 0.00 | 0.00 | +0.00 | hold |