| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 16,001,284 | 16,001,284 | 0 | 9.50 | 7.97 | -1.54 | hold |
| Deep Track Capital, LP | 6,408,863 | 6,999,025 | +590,162 | 2.47 | 2.01 | -0.46 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 4,280,624 | +4,280,624 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 2,390,661 | 3,365,507 | +974,846 | 0.04 | 0.04 | +0.01 | buy |
| Cormorant Asset Management, LP | 4,480,433 | 3,205,433 | -1,275,000 | 4.21 | 3.20 | -1.01 | sell |
| Logos Global Management LP | 1,500,000 | 2,675,000 | +1,175,000 | 1.44 | 2.24 | +0.80 | buy |
| Weiss Asset Management LP | 1,708,328 | 2,581,813 | +873,485 | 0.58 | 0.56 | -0.02 | buy |
| CITADEL ADVISORS LLC | 1,323,728 | 1,972,893 | +649,165 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,122,312 | 1,715,349 | +593,037 | 0.02 | 0.03 | +0.01 | buy |
| MPM BioImpact LLC | 1,811,082 | 1,606,967 | -204,115 | 2.61 | 1.91 | -0.70 | sell |
| Vivo Capital, LLC | 1,000,000 | 1,400,000 | +400,000 | 1.55 | 2.49 | +0.94 | buy |
| JPMORGAN CHASE & CO | 1,088,514 | 1,386,422 | +297,908 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,368,518 | 1,158,732 | -209,786 | 0.04 | 0.03 | -0.01 | sell |
| BlackRock, Inc. | 1,021,851 | 1,094,791 | +72,940 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,294,861 | 1,041,527 | -253,334 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,065,610 | 912,715 | -152,895 | 0.04 | 0.03 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 500,000 | 855,813 | +355,813 | 2.28 | 3.93 | +1.64 | buy |
| JANE STREET GROUP, LLC | 453,625 | 853,386 | +399,761 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 818,126 | 769,766 | -48,360 | 0.08 | 0.07 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 724,794 | 751,897 | +27,103 | 0.00 | 0.00 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 70,140 | 750,777 | +680,637 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 487,583 | 679,244 | +191,661 | 0.02 | 0.02 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 276,772 | 643,268 | +366,496 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 576,092 | 636,187 | +60,095 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 614,482 | 563,602 | -50,880 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 111,331 | 550,351 | +439,020 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 42,917 | 496,242 | +453,325 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 151,256 | 386,960 | +235,704 | 0.04 | 0.09 | +0.05 | buy |
| Rhenman & Partners Asset Management AB | 239,500 | 384,800 | +145,300 | 0.55 | 0.71 | +0.16 | buy |
| Trexquant Investment LP | 495,336 | 377,946 | -117,390 | 0.07 | 0.05 | -0.02 | sell |
| Capricorn Fund Managers Ltd | 0 | 374,866 | +374,866 | 0.00 | 0.58 | +0.58 | buy |
| AQR CAPITAL MANAGEMENT LLC | 46,185 | 358,884 | +312,699 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 239,838 | 341,537 | +101,699 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 325,968 | 336,243 | +10,275 | 0.09 | 0.06 | -0.03 | buy |
| UBS Group AG | 0 | 328,522 | +328,522 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 220,600 | 313,884 | +93,284 | 0.20 | 0.22 | +0.02 | buy |
| Boxer Capital Management, LLC | 275,000 | 275,000 | 0 | 0.67 | 0.40 | -0.27 | hold |
| Susquehanna Portfolio Strategies, LLC | 253,974 | 253,974 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Holocene Advisors, LP | 600,000 | 250,000 | -350,000 | 0.03 | 0.01 | -0.02 | sell |
| Burkehill Global Management, LP | 0 | 250,000 | +250,000 | 0.00 | 0.18 | +0.18 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,424 | 247,742 | -93,682 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 320,472 | 246,869 | -73,603 | 0.04 | 0.02 | -0.01 | sell |
| J. Goldman & Co LP | 136,900 | 215,945 | +79,045 | 0.12 | 0.15 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 127,087 | 215,849 | +88,762 | 0.04 | 0.08 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 191,760 | 215,652 | +23,892 | 2.54 | 2.93 | +0.38 | buy |
| Verition Fund Management LLC | 0 | 207,102 | +207,102 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 193,955 | 187,946 | -6,009 | 1.00 | 0.83 | -0.16 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 167,766 | 183,801 | +16,035 | 0.17 | 0.17 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 178,555 | 180,448 | +1,893 | 0.02 | 0.02 | -0.00 | buy |
| Voleon Capital Management LP | 373,021 | 173,909 | -199,112 | 0.15 | 0.06 | -0.09 | sell |
| Exome Asset Management LLC | 215,376 | 166,493 | -48,883 | 2.36 | 2.00 | -0.36 | sell |
| Longaeva Partners L.P. | 410,000 | 161,557 | -248,443 | 0.37 | 0.09 | -0.28 | sell |
| XTX Topco Ltd | 112,044 | 152,472 | +40,428 | 0.04 | 0.04 | +0.00 | buy |
| FMR LLC | 143,559 | 143,559 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 1,130,233 | 129,434 | -1,000,799 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 142,706 | 128,274 | -14,432 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 111,590 | +111,590 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 118,961 | 109,580 | -9,381 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 109,204 | +109,204 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 80,233 | 106,695 | +26,462 | 0.09 | 0.13 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 74,162 | 105,739 | +31,577 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 100,463 | +100,463 | 0.00 | 0.20 | +0.20 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 100,000 | +100,000 | 0.00 | 0.45 | +0.45 | buy |
| Ghisallo Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.04 | +0.04 | buy |
| SummitTX Capital, L.P. | 0 | 99,371 | +99,371 | 0.00 | 0.05 | +0.05 | buy |
| Jain Global LLC | 15,362 | 99,126 | +83,764 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 56,490 | 87,166 | +30,676 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 61,500 | 87,100 | +25,600 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 110,217 | 85,147 | -25,070 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 0 | 75,000 | +75,000 | 0.00 | 2.45 | +2.45 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 72,269 | 74,760 | +2,491 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 44,950 | 72,875 | +27,925 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 67,500 | 67,500 | 0 | 7.52 | 6.29 | -1.23 | hold |
| CAPITAL FUND MANAGEMENT S.A. | 11,260 | 65,394 | +54,134 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 61,577 | 58,740 | -2,837 | 0.01 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 97,133 | 57,087 | -40,046 | 0.21 | 0.12 | -0.09 | sell |
| Stonepine Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.74 | +0.74 | buy |
| Nuveen, LLC | 33,417 | 48,835 | +15,418 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 120,310 | 46,646 | -73,664 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 19,477 | 45,660 | +26,183 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,296 | 37,839 | +8,543 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 32,254 | +32,254 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 29,678 | +29,678 | 0.00 | 0.03 | +0.03 | buy |
| Aquatic Capital Management LLC | 0 | 28,134 | +28,134 | 0.00 | 0.02 | +0.02 | buy |
| Quantbot Technologies LP | 99 | 27,807 | +27,708 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 28,682 | 27,575 | -1,107 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 457,137 | 27,000 | -430,137 | 0.51 | 0.02 | -0.49 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 16,527 | 26,715 | +10,188 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,518 | 26,590 | +10,072 | 0.05 | 0.09 | +0.04 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48,883 | 25,997 | -22,886 | 0.07 | 0.04 | -0.03 | sell |
| IEQ CAPITAL, LLC | 0 | 24,855 | +24,855 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 24,419 | 24,335 | -84 | 0.22 | 0.17 | -0.05 | sell |
| IMC-Chicago, LLC | 11,352 | 23,048 | +11,696 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 10,526 | 22,919 | +12,393 | 0.01 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 21,089 | 21,545 | +456 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 26,307 | 21,128 | -5,179 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 20,559 | 21,044 | +485 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 11,854 | 19,827 | +7,973 | 0.01 | 0.02 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,500 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,229 | 19,229 | 0 | 0.00 | 0.00 | -0.00 | hold |