| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,372,328 | 1,952,703 | +580,375 | 0.15 | 0.25 | +0.10 | buy |
| TimesSquare Capital Management, LLC | 30,000 | 411,215 | +381,215 | 0.02 | 0.36 | +0.34 | buy |
| Avidity Partners Management LP | 400,000 | 777,172 | +377,172 | 0.71 | 1.78 | +1.07 | buy |
| Avoro Capital Advisors LLC | 1,725,000 | 1,999,999 | +274,999 | 1.19 | 1.78 | +0.58 | buy |
| Integral Health Asset Management, LLC | 300,000 | 500,000 | +200,000 | 2.01 | 4.04 | +2.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,943,056 | 2,117,868 | +174,812 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 99,640 | 200,390 | +100,750 | 0.01 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 91,413 | 183,105 | +91,692 | 5.65 | 12.25 | +6.60 | buy |
| FRED ALGER MANAGEMENT, LLC | 747,605 | 832,951 | +85,346 | 0.19 | 0.27 | +0.08 | buy |
| T. Rowe Price Investment Management, Inc. | 1,148,809 | 1,214,723 | +65,914 | 0.04 | 0.05 | +0.01 | buy |
| Woodline Partners LP | 49,479 | 101,749 | +52,270 | 0.03 | 0.07 | +0.04 | buy |
| Finepoint Capital LP | 302,000 | 331,416 | +29,416 | 5.33 | 9.41 | +4.08 | buy |
| CITADEL ADVISORS LLC | 2,020,608 | 2,034,396 | +13,788 | 0.16 | 0.17 | +0.01 | buy |
| Granahan Investment Management, LLC | 71,934 | 84,562 | +12,628 | 0.11 | 0.17 | +0.06 | buy |
| WEDBUSH SECURITIES INC | 6,890 | 4,126 | +2,764 | 0.02 | 0.01 | 0.00 | sell |
| Dorsey Wright & Associates | 1,111 | 1,074 | -37 | 0.02 | 0.02 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 15,047 | 14,959 | -88 | 0.01 | 0.01 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,053 | 3,687 | -366 | 0.12 | 0.13 | +0.01 | sell |
| MPM BioImpact LLC | 295,111 | 294,190 | -921 | 3.03 | 4.48 | +1.45 | sell |
| LORD, ABBETT & CO. LLC | 194,703 | 176,037 | -18,666 | 0.03 | 0.04 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 410,119 | 391,279 | -18,840 | 0.13 | 0.15 | +0.02 | sell |
| Parkman Healthcare Partners LLC | 80,000 | 53,293 | -26,707 | 0.71 | 0.56 | -0.15 | sell |
| 5AM Venture Management, LLC | 357,486 | 313,210 | -44,276 | 4.54 | 5.14 | +0.60 | sell |
| HighVista Strategies LLC | 129,722 | 59,769 | -69,953 | 3.03 | 1.58 | -1.45 | sell |
| SECTORAL ASSET MANAGEMENT INC | 184,590 | 97,965 | -86,625 | 1.57 | 1.09 | -0.48 | sell |
| Polar Capital Holdings Plc | 1,615,389 | 939,012 | -676,377 | 0.56 | 0.40 | -0.17 | sell |