| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,561,512 | 2,980,249 | +418,737 | 0.01 | 0.02 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 584,263 | 360,200 | +224,063 | 0.07 | 0.05 | 0.00 | sell |
| Camber Capital Management LP | 355,000 | 441,000 | +86,000 | 0.43 | 0.71 | +0.27 | buy |
| CITADEL ADVISORS LLC | 2,265,695 | 2,322,971 | +57,276 | 0.14 | 0.18 | +0.04 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,117,625 | 1,167,358 | +49,733 | 0.24 | 0.27 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 38,689 | 77,468 | +38,779 | 0.13 | 0.17 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 4,800 | 23,457 | +18,657 | 0.04 | 0.20 | +0.16 | buy |
| FRED ALGER MANAGEMENT, LLC | 659,029 | 666,574 | +7,545 | 0.14 | 0.16 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 13,078 | 20,325 | +7,247 | 0.03 | 0.06 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 209,234 | 215,834 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 21,428 | 27,258 | +5,830 | 0.38 | 0.81 | +0.43 | buy |
| MPM BioImpact LLC | 343,235 | 349,063 | +5,828 | 2.35 | 2.64 | +0.30 | buy |
| Clearbridge Investments, LLC | 28,536 | 34,274 | +5,738 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 226,717 | 232,430 | +5,713 | 0.10 | 0.10 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 101,224 | 102,813 | +1,589 | 0.60 | 0.66 | +0.07 | buy |
| HighVista Strategies LLC | 42,249 | 43,541 | +1,292 | 0.68 | 0.76 | +0.08 | buy |
| GSA CAPITAL PARTNERS LLP | 21,724 | 22,127 | +403 | 0.08 | 0.09 | 0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 228,803 | 229,029 | +226 | 1.64 | 1.60 | -0.03 | buy |
| DnB Asset Management AS | 7,372 | 7,509 | +137 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,770,000 | 2,770,100 | +100 | 1.62 | 2.04 | +0.41 | buy |
| VIRTUS ADVISERS, LLC | 2,120 | 2,162 | +42 | 0.05 | 0.05 | +0.01 | buy |
| J. Goldman & Co LP | 18,167 | 16,162 | -2,005 | 0.02 | 0.02 | +0.00 | sell |
| ALPS ADVISORS INC | 49,042 | 43,828 | -5,214 | 0.01 | 0.01 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 125,000 | 100,000 | -25,000 | 0.03 | 0.03 | -0.01 | sell |
| Holocene Advisors, LP | 1,626,341 | 1,585,167 | -41,174 | 0.30 | 0.32 | +0.02 | sell |
| Altium Capital Management LLC | 115,000 | 40,000 | -75,000 | 2.09 | 0.60 | -1.49 | sell |
| Granahan Investment Management, LLC | 283,649 | 172,634 | -111,015 | 0.50 | 0.34 | -0.16 | sell |
| Polar Capital Holdings Plc | 678,169 | 500,000 | -178,169 | 0.18 | 0.12 | -0.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,825,000 | 505,000 | -1,320,000 | 0.15 | 0.04 | -0.10 | sell |