| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 21,751,284 | 21,751,284 | 0 | 26.81 | 32.08 | +5.28 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 21.72 | 22.71 | +0.99 | hold |
| FMR LLC | 3,644,009 | 4,950,224 | +1,306,215 | 0.01 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,561,512 | 2,980,249 | +418,737 | 0.01 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,770,000 | 2,770,100 | +100 | 1.62 | 2.04 | +0.41 | buy |
| CITADEL ADVISORS LLC | 2,265,695 | 2,322,971 | +57,276 | 0.10 | 0.12 | +0.02 | buy |
| Holocene Advisors, LP | 1,626,341 | 1,585,167 | -41,174 | 0.30 | 0.32 | +0.02 | sell |
| GOLDMAN SACHS GROUP INC | 1,251,747 | 1,495,831 | +244,084 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,117,625 | 1,167,358 | +49,733 | 0.24 | 0.27 | +0.02 | buy |
| MARSHALL WACE, LLP | 1,098,630 | 1,154,385 | +55,755 | 0.07 | 0.08 | +0.01 | buy |
| FEDERATED HERMES, INC. | 1,128,428 | 1,130,328 | +1,900 | 0.12 | 0.13 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,021,750 | 998,140 | -23,610 | 0.02 | 0.02 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 0 | 931,480 | +931,480 | 0.00 | 1.64 | +1.64 | buy |
| FRED ALGER MANAGEMENT, LLC | 659,029 | 666,574 | +7,545 | 0.14 | 0.16 | +0.02 | buy |
| Hood River Capital Management LLC | 0 | 646,662 | +646,662 | 0.00 | 0.53 | +0.53 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,825,000 | 505,000 | -1,320,000 | 0.15 | 0.04 | -0.10 | sell |
| Polar Capital Holdings Plc | 678,169 | 500,000 | -178,169 | 0.18 | 0.12 | -0.06 | sell |
| Camber Capital Management LP | 355,000 | 441,000 | +86,000 | 0.60 | 0.86 | +0.26 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 58,245 | 409,203 | +350,958 | 0.00 | 0.02 | +0.02 | buy |
| Finepoint Capital LP | 388,835 | 388,835 | 0 | 4.85 | 2.38 | -2.47 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 584,263 | 360,200 | -224,063 | 0.07 | 0.05 | -0.02 | sell |
| Pictet Asset Management Holding SA | 345,840 | 356,836 | +10,996 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 343,235 | 349,063 | +5,828 | 2.35 | 2.64 | +0.30 | buy |
| Saturn V Capital Management LP | 0 | 298,974 | +298,974 | 0.00 | 5.39 | +5.39 | buy |
| 5AM Venture Management, LLC | 282,313 | 282,313 | 0 | 2.78 | 2.94 | +0.16 | hold |
| Candriam S.C.A. | 239,000 | 239,000 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Woodline Partners LP | 226,717 | 232,430 | +5,713 | 0.10 | 0.10 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 228,803 | 229,029 | +226 | 1.64 | 1.60 | -0.03 | buy |
| Integral Health Asset Management, LLC | 220,000 | 220,000 | 0 | 0.96 | 1.31 | +0.34 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 174,682 | 217,839 | +43,157 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 209,234 | 215,834 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 372,657 | 192,058 | -180,599 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 283,649 | 172,634 | -111,015 | 0.50 | 0.34 | -0.16 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 159,260 | +159,260 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 69,027 | 130,598 | +61,571 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 54,036 | 122,099 | +68,063 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 114,234 | 118,126 | +3,892 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 91,840 | 117,736 | +25,896 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 104,314 | 104,342 | +28 | 0.01 | 0.02 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 101,224 | 102,813 | +1,589 | 0.61 | 0.66 | +0.06 | buy |
| Alyeska Investment Group, L.P. | 125,000 | 100,000 | -25,000 | 0.03 | 0.03 | -0.01 | sell |
| STATE STREET CORP | 44,657 | 87,637 | +42,980 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 116,438 | 86,775 | -29,663 | 0.04 | 0.04 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 38,689 | 77,468 | +38,779 | 0.13 | 0.17 | +0.04 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 75,469 | +75,469 | 0.00 | 0.21 | +0.21 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 66,641 | +66,641 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 33,559 | 62,030 | +28,471 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,500 | 58,410 | -90 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 216,964 | 51,267 | -165,697 | 0.01 | 0.00 | -0.01 | sell |
| Monashee Investment Management LLC | 50,000 | 50,000 | 0 | 0.28 | 0.27 | -0.01 | hold |
| ALPS ADVISORS INC | 49,042 | 43,828 | -5,214 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 42,249 | 43,541 | +1,292 | 0.68 | 0.76 | +0.08 | buy |
| Swiss National Bank | 30,900 | 43,000 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 53,187 | 42,313 | -10,874 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 115,000 | 40,000 | -75,000 | 2.09 | 0.60 | -1.49 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,234 | 35,814 | +17,580 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 28,536 | 34,274 | +5,738 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 27,173 | 31,840 | +4,667 | 0.01 | 0.02 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 21,428 | 27,258 | +5,830 | 0.38 | 0.81 | +0.43 | buy |
| Trexquant Investment LP | 0 | 25,523 | +25,523 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 4,800 | 23,457 | +18,657 | 0.04 | 0.20 | +0.16 | buy |
| GSA CAPITAL PARTNERS LLP | 21,724 | 22,127 | +403 | 0.07 | 0.08 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 20,823 | +20,823 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 13,078 | 20,325 | +7,247 | 0.03 | 0.06 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,244 | 19,213 | +4,969 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 15,790 | 18,051 | +2,261 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 16,855 | +16,855 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 18,167 | 16,162 | -2,005 | 0.03 | 0.04 | +0.01 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 16,000 | +16,000 | 0.00 | 0.02 | +0.02 | buy |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ROYAL BANK OF CANADA | 17,836 | 14,552 | -3,284 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 14,000 | 14,000 | 0 | 0.16 | 0.17 | +0.01 | hold |
| HRT FINANCIAL LP | 0 | 13,592 | +13,592 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,730 | 13,590 | -3,140 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,556 | 13,029 | +473 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 10,300 | 13,000 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 8,146 | 9,164 | +1,018 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,000 | 8,180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 32,224 | 7,928 | -24,296 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 7,372 | 7,509 | +137 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,495 | 6,814 | +319 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 7,340 | 6,402 | -938 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 3,267 | 6,340 | +3,073 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 6,336 | +6,336 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 412 | 5,641 | +5,229 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 5,519 | +5,519 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 4,877 | 5,450 | +573 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,300 | 5,200 | -7,100 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 4,400 | 4,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,753 | 2,753 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIRTUS ADVISERS, LLC | 2,120 | 2,162 | +42 | 0.05 | 0.05 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,672 | +1,672 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 869 | +869 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 565 | 565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRIVATE TRUST CO NA | 122 | 159 | +37 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5 | 11 | +6 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |