| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 423,170 | 1,699,235 | +1,276,065 | 0.05 | 0.02 | -0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 965,405 | +965,405 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 454,268 | +454,268 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 435,839 | +435,839 | 0.00 | 0.63 | +0.63 | buy |
| First Turn Management, LLC | 0 | 262,643 | +262,643 | 0.00 | 0.28 | +0.28 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 258,779 | +258,779 | 0.00 | 0.05 | +0.05 | buy |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.57 | +0.57 | buy |
| Verition Fund Management LLC | 23,527 | 272,768 | +249,241 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 43,239 | 256,655 | +213,416 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 194,741 | +194,741 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 178,084 | +178,084 | 0.00 | 0.84 | +0.84 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 19,390 | 195,490 | +176,100 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 45,000 | 207,000 | +162,000 | 0.27 | 0.16 | -0.10 | buy |
| HRT FINANCIAL LP | 0 | 143,275 | +143,275 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 39,397 | 174,161 | +134,764 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 34,314 | 151,495 | +117,181 | 0.26 | 0.11 | -0.16 | buy |
| Clearbridge Investments, LLC | 28,427 | 135,496 | +107,069 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 89,172 | +89,172 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 5,969 | 90,800 | +84,831 | 0.03 | 0.04 | +0.01 | buy |
| Caitong International Asset Management Co., Ltd | 376 | 84,553 | +84,177 | 0.01 | 0.42 | +0.41 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 71,010 | +71,010 | 0.00 | 0.12 | +0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 70,943 | +70,943 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 67,500 | +67,500 | 0.00 | 2.75 | +2.75 | buy |
| Engineers Gate Manager LP | 0 | 58,810 | +58,810 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 58,229 | +58,229 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 0 | 53,700 | +53,700 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 44,779 | +44,779 | 0.00 | 0.03 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 0 | 43,735 | +43,735 | 0.00 | 0.01 | +0.01 | buy |
| Voleon Capital Management LP | 0 | 40,273 | +40,273 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 39,324 | +39,324 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 36,405 | +36,405 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 0 | 33,577 | +33,577 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 32,245 | +32,245 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 3,000 | 35,052 | +32,052 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 14,314 | 45,015 | +30,701 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 0 | 28,200 | +28,200 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 21,857 | 48,298 | +26,441 | 0.00 | 0.00 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 25,180 | +25,180 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 5,189 | 25,000 | +19,811 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 17,526 | +17,526 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 15,469 | +15,469 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.10 | +0.10 | buy |
| MYDA Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 17,571 | 30,690 | +13,119 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,400 | +11,400 | 0.00 | 0.01 | +0.01 | buy |
| Quarry LP | 1,800 | 9,001 | +7,201 | 0.02 | 0.02 | -0.00 | buy |
| Covestor Ltd | 0 | 6,437 | +6,437 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 2,971 | 8,021 | +5,050 | 0.00 | 0.00 | -0.00 | buy |
| Centiva Capital, LP | 0 | 4,500 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 80,350 | 84,347 | +3,997 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 3,535 | +3,535 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,753 | 5,919 | +3,166 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 59,553 | 62,385 | +2,832 | 0.00 | 0.00 | -0.00 | buy |
| Delos Wealth Advisors, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,138 | 7,296 | +1,158 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 17 | 1,101 | +1,084 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 952 | +952 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 888 | +888 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,555 | 2,340 | +785 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 42,300 | 43,000 | +700 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 100 | 710 | +610 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 72,851 | 73,365 | +514 | 0.02 | 0.00 | -0.02 | buy |
| Virtus Investment Advisers, LLC | 2,136 | 2,585 | +449 | 0.03 | 0.01 | -0.03 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 82 | +82 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 8 | 54 | +46 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 257 | 272 | +15 | 0.00 | 0.00 | -0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| WPG Advisers, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 19,751,284 | 19,751,284 | 0 | 33.31 | 5.74 | -27.56 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,972 | 18,972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 10,600 | 10,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| J.Safra Asset Management Corp | 51 | 51 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| True Wealth Design, LLC | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Legal & General Group Plc | 20,905 | 20,905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Advisors Asset Management, Inc. | 4,009 | 3,994 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Riggs Asset Managment Co. Inc. | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 50 | 16 | -34 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 49 | 0 | -49 | 0.00 | 0.00 | -0.00 | sell |
| Geneos Wealth Management Inc. | 55 | 0 | -55 | 0.00 | 0.00 | -0.00 | sell |
| PRIVATE TRUST CO NA | 120 | 52 | -68 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 110 | 0 | -110 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 120 | 0 | -120 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,949 | 12,712 | -237 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 274 | 0 | -274 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 490 | 0 | -490 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 509 | 0 | -509 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 120,869 | 120,243 | -626 | 0.00 | 0.00 | -0.00 | sell |