| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,751,284 | 19,751,284 | 0 | 33.31 | 5.74 | -27.56 | hold |
| Avoro Capital Advisors LLC | 4,150,000 | 2,000,000 | -2,150,000 | 3.43 | 0.19 | -3.24 | sell |
| Cormorant Asset Management, LP | 8,494,151 | 1,994,173 | -6,499,978 | 29.86 | 0.99 | -28.88 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 423,170 | 1,699,235 | +1,276,065 | 0.05 | 0.02 | -0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 965,405 | +965,405 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,613,233 | 822,957 | -1,790,276 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 5,730,549 | 726,932 | -5,003,617 | 0.02 | 0.00 | -0.01 | sell |
| Nuveen, LLC | 791,555 | 635,699 | -155,856 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 454,268 | +454,268 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 435,839 | +435,839 | 0.00 | 0.63 | +0.63 | buy |
| GOLDMAN SACHS GROUP INC | 1,275,569 | 362,871 | -912,698 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 529,211 | 321,109 | -208,102 | 0.03 | 0.00 | -0.03 | sell |
| Verition Fund Management LLC | 23,527 | 272,768 | +249,241 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 0 | 262,643 | +262,643 | 0.00 | 0.28 | +0.28 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 258,779 | +258,779 | 0.00 | 0.05 | +0.05 | buy |
| MORGAN STANLEY | 43,239 | 256,655 | +213,416 | 0.00 | 0.00 | -0.00 | buy |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.57 | +0.57 | buy |
| Rhenman & Partners Asset Management AB | 45,000 | 207,000 | +162,000 | 0.27 | 0.16 | -0.10 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 19,390 | 195,490 | +176,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 194,741 | +194,741 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 178,084 | +178,084 | 0.00 | 0.84 | +0.84 | buy |
| JPMORGAN CHASE & CO | 39,397 | 174,161 | +134,764 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 34,314 | 151,495 | +117,181 | 0.26 | 0.11 | -0.16 | buy |
| HRT FINANCIAL LP | 0 | 143,275 | +143,275 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 28,427 | 135,496 | +107,069 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 142,320 | 134,835 | -7,485 | 0.36 | 0.05 | -0.31 | sell |
| Candriam S.C.A. | 144,830 | 133,642 | -11,188 | 0.04 | 0.01 | -0.03 | sell |
| Catalio Capital Management, LP | 162,596 | 133,131 | -29,465 | 1.61 | 0.18 | -1.43 | sell |
| Pictet Asset Management Holding SA | 147,721 | 131,991 | -15,730 | 0.01 | 0.00 | -0.01 | sell |
| BlackRock, Inc. | 327,342 | 125,381 | -201,961 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 120,869 | 120,243 | -626 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 186,152 | 106,610 | -79,542 | 0.01 | 0.00 | -0.01 | sell |
| Caption Management, LLC | 5,969 | 90,800 | +84,831 | 0.03 | 0.04 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 89,172 | +89,172 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 376 | 84,553 | +84,177 | 0.01 | 0.42 | +0.41 | buy |
| UBS Group AG | 80,350 | 84,347 | +3,997 | 0.00 | 0.00 | -0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 72,851 | 73,365 | +514 | 0.02 | 0.00 | -0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 71,010 | +71,010 | 0.00 | 0.12 | +0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 70,943 | +70,943 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 67,500 | +67,500 | 0.00 | 2.75 | +2.75 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 109,969 | 65,256 | -44,713 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 59,553 | 62,385 | +2,832 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 310,602 | 60,854 | -249,748 | 0.08 | 0.00 | -0.08 | sell |
| Engineers Gate Manager LP | 0 | 58,810 | +58,810 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 58,229 | +58,229 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 0 | 53,700 | +53,700 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 64,564 | 52,886 | -11,678 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,674,041 | 49,334 | -1,624,707 | 0.07 | 0.00 | -0.07 | sell |
| ROYAL BANK OF CANADA | 21,857 | 48,298 | +26,441 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 14,314 | 45,015 | +30,701 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 44,779 | +44,779 | 0.00 | 0.03 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 0 | 43,735 | +43,735 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 42,300 | 43,000 | +700 | 0.00 | 0.00 | -0.00 | buy |
| Voleon Capital Management LP | 0 | 40,273 | +40,273 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 39,324 | +39,324 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 36,405 | +36,405 | 0.00 | 0.04 | +0.04 | buy |
| Bellevue Group AG | 3,000 | 35,052 | +32,052 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 38,204 | 33,878 | -4,326 | 0.02 | 0.00 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 0 | 33,577 | +33,577 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 32,245 | +32,245 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 34,290 | 30,756 | -3,534 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 17,571 | 30,690 | +13,119 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 82,023 | 30,000 | -52,023 | 0.79 | 0.03 | -0.76 | sell |
| Rock Springs Capital Management LP | 0 | 28,200 | +28,200 | 0.00 | 0.01 | +0.01 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 25,180 | +25,180 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 5,189 | 25,000 | +19,811 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 20,905 | 20,905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hudson Bay Capital Management LP | 105,000 | 20,000 | -85,000 | 0.03 | 0.00 | -0.03 | sell |
| HighVista Strategies LLC | 20,953 | 19,059 | -1,894 | 0.36 | 0.03 | -0.33 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,972 | 18,972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 138,368 | 18,790 | -119,578 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 17,526 | +17,526 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 15,469 | +15,469 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.10 | +0.10 | buy |
| MYDA Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 51,409 | 13,706 | -37,703 | 0.10 | 0.01 | -0.09 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,949 | 12,712 | -237 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,752 | 11,954 | -3,798 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,400 | +11,400 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 52,719 | 11,002 | -41,717 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 10,600 | 10,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 186,568 | 9,800 | -176,768 | 0.02 | 0.00 | -0.02 | sell |
| Quarry LP | 1,800 | 9,001 | +7,201 | 0.02 | 0.02 | -0.00 | buy |
| CITIGROUP INC | 2,971 | 8,021 | +5,050 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 17,326 | 7,890 | -9,436 | 0.02 | 0.00 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,138 | 7,296 | +1,158 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 6,437 | +6,437 | 0.00 | 0.03 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,753 | 5,919 | +3,166 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 9,139 | 5,539 | -3,600 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 0 | 4,500 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FNY Investment Advisers, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.01 | +0.01 | buy |
| Advisors Asset Management, Inc. | 4,009 | 3,994 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 3,535 | +3,535 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 2,136 | 2,585 | +449 | 0.03 | 0.01 | -0.03 | buy |
| Russell Investments Group, Ltd. | 5,460 | 2,357 | -3,103 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 1,555 | 2,340 | +785 | 0.00 | 0.00 | -0.00 | buy |