| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 1,039,289 | +1,039,289 | 0.00 | 12.32 | +12.32 | buy |
| Holocene Advisors, LP | 105,822 | 961,330 | +855,508 | 0.03 | 0.23 | +0.20 | buy |
| Avoro Capital Advisors LLC | 1,999,999 | 2,580,000 | +580,001 | 1.78 | 2.15 | +0.37 | buy |
| Finepoint Capital LP | 331,416 | 895,000 | +563,584 | 9.41 | 0.02 | -9.39 | buy |
| FMR LLC | 3,397,253 | 3,847,678 | +450,425 | 0.02 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 471,319 | 909,151 | +437,832 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 234,250 | 598,510 | +364,260 | 0.04 | 0.10 | +0.06 | buy |
| Cormorant Asset Management, LP | 8,142,100 | 8,494,151 | +352,051 | 27.07 | 24.56 | -2.51 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 228,992 | +228,992 | 0.00 | 3.15 | +3.15 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 391,279 | 612,050 | +220,771 | 0.15 | 0.22 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,152 | 214,116 | +196,964 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,117,868 | 2,314,012 | +196,144 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 0 | 185,000 | +185,000 | 0.00 | 0.08 | +0.08 | buy |
| Senator Investment Group LP | 0 | 155,000 | +155,000 | 0.00 | 0.40 | +0.40 | buy |
| Logos Global Management LP | 0 | 150,000 | +150,000 | 0.00 | 1.01 | +1.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 128,700 | +128,700 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 82,398 | +82,398 | 0.00 | 0.11 | +0.11 | buy |
| TimesSquare Capital Management, LLC | 411,215 | 488,805 | +77,590 | 0.36 | 0.43 | +0.07 | buy |
| Pictet Asset Management Holding SA | 541,901 | 616,563 | +74,662 | 0.04 | 0.04 | +0.00 | buy |
| JANE STREET GROUP, LLC | 4,991 | 77,949 | +72,958 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 7,043 | 75,000 | +67,957 | 0.05 | 0.49 | +0.44 | buy |
| MORGAN STANLEY | 0 | 66,514 | +66,514 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 65,000 | +65,000 | 0.00 | 0.94 | +0.94 | buy |
| VANGUARD GROUP INC | 13,591 | 73,657 | +60,066 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 96,687 | 151,134 | +54,447 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.93 | +0.93 | buy |
| Ensign Peak Advisors, Inc | 9,600 | 53,648 | +44,048 | 0.00 | 0.01 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 56,000 | 100,000 | +44,000 | 0.07 | 0.11 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,530 | 74,108 | +43,578 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 84,562 | 126,772 | +42,210 | 0.17 | 0.25 | +0.08 | buy |
| ALPS ADVISORS INC | 0 | 38,897 | +38,897 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 35,090 | 73,060 | +37,970 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 35,335 | +35,335 | 0.00 | 0.05 | +0.05 | buy |
| SIMPLEX TRADING, LLC | 0 | 35,179 | +35,179 | 0.00 | 0.07 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 53,293 | 82,009 | +28,716 | 0.56 | 0.70 | +0.14 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 70,988 | +20,988 | 0.93 | 0.85 | -0.08 | buy |
| NATIXIS | 0 | 20,317 | +20,317 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 101,749 | 121,754 | +20,005 | 0.07 | 0.08 | +0.01 | buy |
| Sand Grove Capital Management LLP | 0 | 20,000 | +20,000 | 0.00 | 0.37 | +0.37 | buy |
| Qube Research & Technologies Ltd | 0 | 18,920 | +18,920 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 18,728 | +18,728 | 0.00 | 0.08 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 17,236 | +17,236 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 15,291 | +15,291 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 17,095 | 30,154 | +13,059 | 0.01 | 0.03 | +0.01 | buy |
| CenterBook Partners LP | 11,421 | 22,781 | +11,360 | 0.08 | 0.17 | +0.09 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,227 | +11,227 | 0.00 | 0.06 | +0.06 | buy |
| Jefferies Financial Group Inc. | 0 | 10,575 | +10,575 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 73,711 | 83,921 | +10,210 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 20,800 | 30,341 | +9,541 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 200,390 | 209,142 | +8,752 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 6,488 | +6,488 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 12,587 | 18,699 | +6,112 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,214,723 | 1,220,602 | +5,879 | 0.05 | 0.05 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 5,398 | +5,398 | 0.00 | 0.08 | +0.08 | buy |
| FORA Capital, LLC | 9,302 | 14,425 | +5,123 | 0.05 | 0.07 | +0.03 | buy |
| Squarepoint Ops LLC | 13,909 | 18,903 | +4,994 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 43,808 | 48,774 | +4,966 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,400 | 11,000 | +4,600 | 0.03 | 0.06 | +0.02 | buy |
| Pearl River Capital, LLC | 0 | 4,292 | +4,292 | 0.00 | 0.04 | +0.04 | buy |
| Allianz Asset Management GmbH | 8,100 | 12,300 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,589 | +3,589 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 3,505 | +3,505 | 0.00 | 0.07 | +0.07 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Partners, LTD. | 0 | 3,350 | +3,350 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,312 | 6,114 | +2,802 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 24,083 | 26,788 | +2,705 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 32 | 2,297 | +2,265 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,920 | 6,000 | +2,080 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 36,353 | 38,185 | +1,832 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 5,737 | 7,202 | +1,465 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 850 | +850 | 0.00 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 1,309 | 2,017 | +708 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 565 | +565 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,862 | 7,266 | +404 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 294,190 | 294,576 | +386 | 4.48 | 4.16 | -0.31 | buy |
| WEDBUSH SECURITIES INC | 4,126 | 4,455 | +329 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 96 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,178 | 15,231 | +53 | 0.00 | 0.00 | -0.00 | buy |
| PRIVATE TRUST CO NA | 97 | 138 | +41 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 21,751,284 | 21,751,284 | 0 | 33.43 | 32.87 | -0.56 | hold |
| TWO SIGMA INVESTMENTS, LP | 3,853 | 3,853 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 59,769 | 59,769 | 0 | 1.58 | 1.31 | -0.27 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 165 | 91 | -74 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 11,332 | 11,222 | -110 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,048 | 15,937 | -111 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 5,147 | 5,001 | -146 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 192 | 0 | -192 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,610 | 15,096 | -514 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5,140 | 4,149 | -991 | 0.00 | 0.00 | -0.00 | sell |
| Dorsey Wright & Associates | 1,074 | 0 | -1,074 | 0.02 | 0.00 | -0.02 | sell |
| UBS Group AG | 1,125 | 0 | -1,125 | 0.00 | 0.00 | -0.00 | sell |
| Polar Capital Holdings Plc | 939,012 | 937,115 | -1,897 | 0.40 | 0.35 | -0.05 | sell |
| VIRTUS ADVISERS, LLC | 3,687 | 1,605 | -2,082 | 0.13 | 0.06 | -0.07 | sell |
| US BANCORP \DE\ | 3,547 | 0 | -3,547 | 0.00 | 0.00 | -0.00 | sell |
| Belvedere Trading LLC | 3,931 | 0 | -3,931 | 0.03 | 0.00 | -0.03 | sell |