| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Holocene Advisors, LP | 105,822 | 961,330 | +855,508 | 0.03 | 0.23 | +0.20 | buy |
| Avoro Capital Advisors LLC | 1,999,999 | 2,580,000 | +580,001 | 1.78 | 2.15 | +0.37 | buy |
| Finepoint Capital LP | 331,416 | 895,000 | +563,584 | 9.41 | 0.02 | -9.39 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 234,250 | 598,510 | +364,260 | 0.04 | 0.11 | 0.00 | buy |
| Cormorant Asset Management, LP | 8,142,100 | 8,494,151 | +352,051 | 27.07 | 24.50 | -2.57 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 391,279 | 612,050 | +220,771 | 0.15 | 0.22 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,117,868 | 2,314,012 | +196,144 | 0.02 | 0.02 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 411,215 | 488,805 | +77,590 | 0.36 | 0.43 | +0.07 | buy |
| SOROS FUND MANAGEMENT LLC | 56,000 | 100,000 | +44,000 | 0.05 | 0.08 | +0.03 | buy |
| Granahan Investment Management, LLC | 84,562 | 126,772 | +42,210 | 0.17 | 0.25 | +0.08 | buy |
| Parkman Healthcare Partners LLC | 53,293 | 82,009 | +28,716 | 0.56 | 0.70 | +0.14 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 70,988 | +20,988 | 0.93 | 0.85 | -0.08 | buy |
| Woodline Partners LP | 101,749 | 121,754 | +20,005 | 0.07 | 0.08 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 45,181 | 28,417 | +16,764 | 0.03 | 0.02 | 0.00 | sell |
| CenterBook Partners LP | 11,421 | 22,781 | +11,360 | 0.08 | 0.17 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 200,390 | 209,142 | +8,752 | 0.01 | 0.01 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,214,723 | 1,220,602 | +5,879 | 0.05 | 0.05 | -0.00 | buy |
| FORA Capital, LLC | 9,302 | 14,425 | +5,123 | 0.05 | 0.07 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,400 | 11,000 | +4,600 | 0.03 | 0.06 | +0.02 | buy |
| MPM BioImpact LLC | 294,190 | 294,576 | +386 | 4.48 | 4.16 | -0.31 | buy |
| WEDBUSH SECURITIES INC | 4,126 | 4,455 | +329 | 0.01 | 0.01 | 0.00 | buy |
| Polar Capital Holdings Plc | 939,012 | 937,115 | -1,897 | 0.40 | 0.35 | -0.05 | sell |
| VIRTUS ADVISERS, LLC | 3,687 | 1,605 | -2,082 | 0.13 | 0.06 | -0.07 | sell |
| Tri Locum Partners LP | 53,300 | 47,604 | -5,696 | 0.97 | 1.41 | +0.44 | sell |
| 5AM Venture Management, LLC | 313,210 | 302,630 | -10,580 | 5.14 | 4.85 | -0.29 | sell |
| LORD, ABBETT & CO. LLC | 176,037 | 159,319 | -16,718 | 0.04 | 0.03 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 832,951 | 810,586 | -22,365 | 0.27 | 0.26 | -0.01 | sell |
| CITADEL ADVISORS LLC | 2,034,396 | 2,008,660 | -25,736 | 0.17 | 0.17 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 183,105 | 143,479 | -39,626 | 12.25 | 5.16 | -7.09 | sell |
| SECTORAL ASSET MANAGEMENT INC | 97,965 | 30,005 | -67,960 | 1.09 | 0.78 | -0.31 | sell |
| Sofinnova Investments, Inc. | 292,805 | 113,757 | -179,048 | 1.05 | 0.38 | -0.67 | sell |
| Integral Health Asset Management, LLC | 500,000 | 220,000 | -280,000 | 4.04 | 1.92 | -2.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,952,703 | 1,525,717 | -426,986 | 0.25 | 0.19 | -0.06 | sell |