| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,950,224 | 6,341,391 | +1,391,167 | 0.02 | 0.02 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 931,480 | 1,772,211 | +840,731 | 1.64 | 3.34 | +1.70 | buy |
| Polar Capital Holdings Plc | 500,000 | 1,100,000 | +600,000 | 0.12 | 0.33 | +0.21 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,980,249 | 3,343,643 | +363,394 | 0.02 | 0.02 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 332,522 | +332,522 | 0.00 | 0.72 | +0.72 | buy |
| Walleye Capital LLC | 0 | 208,896 | +208,896 | 0.00 | 0.11 | +0.11 | buy |
| GOLDMAN SACHS GROUP INC | 1,495,831 | 1,674,664 | +178,833 | 0.01 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,130,328 | 1,280,052 | +149,724 | 0.13 | 0.15 | +0.03 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,167,358 | 1,311,619 | +144,261 | 0.27 | 0.31 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 98,719 | +98,719 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 1,154,385 | 1,245,299 | +90,914 | 0.08 | 0.08 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 64,384 | +64,384 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 232,430 | 293,535 | +61,105 | 0.10 | 0.11 | +0.01 | buy |
| Finepoint Capital LP | 388,835 | 447,935 | +59,100 | 2.38 | 2.80 | +0.41 | buy |
| Saturn V Capital Management LP | 298,974 | 346,111 | +47,137 | 5.39 | 7.34 | +1.95 | buy |
| TD ASSET MANAGEMENT INC | 215,834 | 261,634 | +45,800 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 159,260 | 204,373 | +45,113 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 409,203 | 448,860 | +39,657 | 0.02 | 0.03 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 75,469 | 111,133 | +35,664 | 0.21 | 0.33 | +0.12 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 118,126 | 142,702 | +24,576 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 998,140 | 1,022,604 | +24,464 | 0.02 | 0.02 | +0.00 | buy |
| UBS Group AG | 6,340 | 27,918 | +21,578 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 20,748 | +20,748 | 0.00 | 0.10 | +0.10 | buy |
| Caption Management, LLC | 0 | 12,371 | +12,371 | 0.00 | 0.03 | +0.03 | buy |
| Cinctive Capital Management LP | 0 | 10,576 | +10,576 | 0.00 | 0.03 | +0.03 | buy |
| WEXFORD CAPITAL LP | 14,000 | 24,000 | +10,000 | 0.17 | 0.33 | +0.16 | buy |
| Clearbridge Investments, LLC | 34,274 | 43,380 | +9,106 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 5,450 | 14,261 | +8,811 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 7,633 | +7,633 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 7,500 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 666,574 | 673,773 | +7,199 | 0.16 | 0.17 | +0.01 | buy |
| ALPS ADVISORS INC | 43,828 | 50,995 | +7,167 | 0.01 | 0.02 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,814 | 42,236 | +6,422 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 66,641 | 72,993 | +6,352 | 0.02 | 0.03 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 6,250 | +6,250 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 5,028 | +5,028 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 16,000 | 20,740 | +4,740 | 0.02 | 0.03 | +0.01 | buy |
| Allianz Asset Management GmbH | 5,200 | 9,900 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 4,000 | +4,000 | 0.00 | 0.18 | +0.18 | buy |
| STATE STREET CORP | 87,637 | 91,545 | +3,908 | 0.00 | 0.00 | +0.00 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 3,208 | +3,208 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 646,662 | 649,590 | +2,928 | 0.53 | 0.52 | -0.01 | buy |
| Advisors Asset Management, Inc. | 0 | 2,206 | +2,206 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,468 | 79,648 | +2,180 | 0.17 | 0.19 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,590 | 15,456 | +1,866 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 18,051 | 19,480 | +1,429 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 14,552 | 15,895 | +1,343 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,814 | 8,146 | +1,332 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 1,250 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,212 | +1,212 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 20,823 | 22,025 | +1,202 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5,519 | 6,532 | +1,013 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 7,509 | 8,356 | +847 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,410 | 58,950 | +540 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 565 | 903 | +338 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,180 | 8,500 | +320 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 869 | 1,030 | +161 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 6,336 | 6,371 | +35 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 159 | 193 | +34 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 11 | 25 | +14 | 0.00 | 0.00 | -0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| JANUS HENDERSON GROUP PLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 43,541 | 43,541 | 0 | 0.76 | 0.88 | +0.12 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,753 | 2,753 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Camber Capital Management LP | 441,000 | 441,000 | 0 | 0.86 | 0.93 | +0.07 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| J.Safra Asset Management Corp | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 43,000 | 43,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 8,494,151 | 8,494,151 | 0 | 22.71 | 25.26 | +2.55 | hold |
| Avoro Capital Advisors LLC | 2,770,100 | 2,770,100 | 0 | 2.04 | 2.12 | +0.09 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bellevue Group AG | 4,400 | 4,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Holocene Advisors, LP | 1,585,167 | 1,585,167 | 0 | 0.32 | 0.28 | -0.04 | hold |
| 5AM Venture Management, LLC | 282,313 | 282,313 | 0 | 2.94 | 3.65 | +0.71 | hold |
| Erste Asset Management GmbH | 15,000 | 15,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SUMMIT SECURITIES GROUP LLC | 90 | 0 | -90 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,029 | 12,865 | -164 | 0.00 | 0.00 | +0.00 | sell |
| AXA S.A. | 104,342 | 104,178 | -164 | 0.02 | 0.02 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 9,164 | 8,971 | -193 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,213 | 18,972 | -241 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,162 | 1,322 | -840 | 0.05 | 0.03 | -0.02 | sell |
| BARCLAYS PLC | 5,641 | 4,646 | -995 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,672 | 0 | -1,672 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 13,000 | 11,100 | -1,900 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 117,736 | 115,416 | -2,320 | 0.00 | 0.00 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 27,258 | 23,687 | -3,571 | 0.81 | 0.86 | +0.04 | sell |
| ADAR1 Capital Management, LLC | 23,457 | 17,424 | -6,033 | 0.20 | 0.19 | -0.00 | sell |
| Russell Investments Group, Ltd. | 62,030 | 55,890 | -6,140 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 6,402 | 0 | -6,402 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 7,928 | 0 | -7,928 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 356,836 | 346,617 | -10,219 | 0.02 | 0.02 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 20,325 | 9,229 | -11,096 | 0.06 | 0.03 | -0.03 | sell |
| Candriam S.C.A. | 239,000 | 227,476 | -11,524 | 0.07 | 0.07 | +0.00 | sell |
| HRT FINANCIAL LP | 13,592 | 0 | -13,592 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 16,162 | 0 | -16,162 | 0.04 | 0.00 | -0.04 | sell |
| ExodusPoint Capital Management, LP | 16,855 | 0 | -16,855 | 0.01 | 0.00 | -0.01 | sell |