| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 931,480 | 1,772,211 | +840,731 | 1.64 | 3.34 | +1.70 | buy |
| Polar Capital Holdings Plc | 500,000 | 1,100,000 | +600,000 | 0.12 | 0.33 | +0.21 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,980,249 | 3,343,643 | +363,394 | 0.02 | 0.02 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 360,200 | 206,568 | +153,632 | 0.05 | 0.03 | 0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,167,358 | 1,311,619 | +144,261 | 0.27 | 0.31 | +0.04 | buy |
| Woodline Partners LP | 232,430 | 293,535 | +61,105 | 0.10 | 0.11 | +0.01 | buy |
| Finepoint Capital LP | 388,835 | 447,935 | +59,100 | 1.42 | 1.48 | +0.06 | buy |
| Saturn V Capital Management LP | 298,974 | 346,111 | +47,137 | 5.39 | 7.34 | +1.95 | buy |
| TD ASSET MANAGEMENT INC | 215,834 | 261,634 | +45,800 | 0.01 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 75,469 | 111,133 | +35,664 | 0.21 | 0.33 | +0.12 | buy |
| Y-Intercept (Hong Kong) Ltd | 20,325 | 9,229 | +11,096 | 0.06 | 0.03 | 0.00 | sell |
| WEXFORD CAPITAL LP | 14,000 | 24,000 | +10,000 | 0.17 | 0.21 | +0.04 | buy |
| Clearbridge Investments, LLC | 34,274 | 43,380 | +9,106 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 666,574 | 673,773 | +7,199 | 0.16 | 0.17 | +0.01 | buy |
| ALPS ADVISORS INC | 43,828 | 50,995 | +7,167 | 0.01 | 0.02 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 66,641 | 72,993 | +6,352 | 0.02 | 0.03 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 16,000 | 20,740 | +4,740 | 0.06 | 0.09 | 0.00 | buy |
| Hood River Capital Management LLC | 646,662 | 649,590 | +2,928 | 0.53 | 0.52 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 77,468 | 79,648 | +2,180 | 0.17 | 0.19 | 0.00 | buy |
| DnB Asset Management AS | 7,509 | 8,356 | +847 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,162 | 1,322 | -840 | 0.05 | 0.03 | -0.02 | sell |
| SECTORAL ASSET MANAGEMENT INC | 27,258 | 23,687 | -3,571 | 0.81 | 0.86 | +0.04 | sell |
| ADAR1 Capital Management, LLC | 23,457 | 17,424 | -6,033 | 0.20 | 0.19 | -0.00 | sell |
| Candriam S.C.A. | 239,000 | 227,476 | -11,524 | 0.06 | 0.07 | +0.01 | sell |
| Integral Health Asset Management, LLC | 220,000 | 200,000 | -20,000 | 1.25 | 0.92 | -0.33 | sell |
| MPM BioImpact LLC | 349,063 | 315,230 | -33,833 | 2.64 | 2.42 | -0.22 | sell |
| Granahan Investment Management, LLC | 172,634 | 136,438 | -36,196 | 0.34 | 0.31 | -0.03 | sell |
| Parkman Healthcare Partners LLC | 102,813 | 54,294 | -48,519 | 0.66 | 0.39 | -0.27 | sell |
| CITADEL ADVISORS LLC | 2,322,971 | 2,186,866 | -136,105 | 0.18 | 0.16 | -0.02 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 229,029 | 85 | -228,944 | 1.60 | 0.00 | -1.60 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 505,000 | 155,000 | -350,000 | 0.04 | 0.01 | -0.03 | sell |
| BVF INC/IL | 21,751,284 | 19,751,284 | -2,000,000 | 32.08 | 36.25 | +4.16 | sell |