| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,751,284 | 19,751,284 | 0 | 5.74 | 8.76 | +3.02 | hold |
| Deep Track Capital, LP | 0 | 4,610,071 | +4,610,071 | 0.00 | 1.39 | +1.39 | buy |
| Cormorant Asset Management, LP | 1,994,173 | 4,355,433 | +2,361,260 | 0.99 | 3.25 | +2.27 | buy |
| D. E. Shaw & Co., Inc. | 0 | 2,480,767 | +2,480,767 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 11,100 | 2,095,988 | +2,084,888 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 1,750,000 | +1,750,000 | 0.00 | 1.54 | +1.54 | buy |
| JANE STREET GROUP, LLC | 0 | 1,682,148 | +1,682,148 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,699,235 | 1,571,071 | -128,164 | 0.02 | 0.04 | +0.01 | sell |
| MORGAN STANLEY | 256,655 | 1,044,581 | +787,926 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.85 | +0.85 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 822,957 | 959,553 | +136,596 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 174,161 | 837,739 | +663,578 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 89,172 | 802,722 | +713,550 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 454,268 | 784,811 | +330,543 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 9,800 | 772,500 | +762,700 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 635,699 | 637,434 | +1,735 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 143,275 | 635,901 | +492,626 | 0.00 | 0.03 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194,741 | 549,236 | +354,495 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 25,000 | 500,000 | +475,000 | 0.00 | 0.05 | +0.05 | buy |
| Voleon Capital Management LP | 40,273 | 499,099 | +458,826 | 0.01 | 0.14 | +0.13 | buy |
| Jump Financial, LLC | 0 | 425,559 | +425,559 | 0.00 | 0.07 | +0.07 | buy |
| Soleus Capital Management, L.P. | 0 | 400,000 | +400,000 | 0.00 | 0.22 | +0.22 | buy |
| CITADEL ADVISORS LLC | 49,334 | 380,890 | +331,556 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 207,000 | 364,000 | +157,000 | 0.16 | 0.45 | +0.28 | buy |
| STEMPOINT CAPITAL LP | 0 | 348,401 | +348,401 | 0.00 | 0.79 | +0.79 | buy |
| Weiss Asset Management LP | 0 | 332,961 | +332,961 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 965,405 | 322,261 | -643,144 | 0.05 | 0.02 | -0.03 | sell |
| BlackRock, Inc. | 125,381 | 286,593 | +161,212 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 250,000 | 275,000 | +25,000 | 0.57 | 0.79 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 362,871 | 270,665 | -92,206 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 120,243 | 266,150 | +145,907 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 262,643 | 262,643 | 0 | 0.28 | 0.40 | +0.11 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 253,974 | +253,974 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 84,347 | 239,020 | +154,673 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 221,616 | +221,616 | 0.00 | 0.05 | +0.05 | buy |
| ExodusPoint Capital Management, LP | 0 | 212,996 | +212,996 | 0.00 | 0.03 | +0.03 | buy |
| Granahan Investment Management, LLC | 0 | 198,307 | +198,307 | 0.00 | 0.11 | +0.11 | buy |
| Eagle Health Investments LP | 0 | 187,600 | +187,600 | 0.00 | 0.54 | +0.54 | buy |
| Trexquant Investment LP | 0 | 184,319 | +184,319 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,002 | 183,552 | +172,550 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 726,932 | 156,276 | -570,656 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 134,472 | +134,472 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 133,642 | 134,329 | +687 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 39,324 | 131,700 | +92,376 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,842 | 130,964 | +129,122 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 134,835 | 127,465 | -7,370 | 0.05 | 0.09 | +0.04 | sell |
| TD ASSET MANAGEMENT INC | 106,610 | 126,744 | +20,134 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 30,690 | 121,640 | +90,950 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 103,516 | +103,516 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 101,467 | +101,467 | 0.00 | 0.05 | +0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 95,972 | +95,972 | 0.00 | 0.03 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 89,236 | +89,236 | 0.00 | 0.10 | +0.10 | buy |
| Walleye Trading LLC | 53,700 | 87,390 | +33,690 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,256 | 85,570 | +20,314 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 78,638 | +78,638 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 0 | 75,752 | +75,752 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 62,385 | 72,606 | +10,221 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 11,400 | 71,962 | +60,562 | 0.01 | 0.15 | +0.13 | buy |
| CONGRESS ASSET MANAGEMENT CO | 73,365 | 71,096 | -2,269 | 0.00 | 0.01 | +0.00 | sell |
| Jain Global LLC | 0 | 70,611 | +70,611 | 0.00 | 0.01 | +0.01 | buy |
| Lion Point Capital, LP | 67,500 | 67,500 | 0 | 2.75 | 4.60 | +1.85 | hold |
| BNP Paribas Asset Management Holding S.A. | 272 | 61,948 | +61,676 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 28,200 | 61,700 | +33,500 | 0.01 | 0.04 | +0.03 | buy |
| Swiss National Bank | 43,000 | 61,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 59,280 | +59,280 | 0.00 | 0.53 | +0.53 | buy |
| ALPS ADVISORS INC | 30,756 | 58,169 | +27,413 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 52,886 | 50,973 | -1,913 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 16 | 50,251 | +50,235 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 50,217 | +50,217 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 60,854 | 49,168 | -11,686 | 0.00 | 0.00 | +0.00 | sell |
| Cinctive Capital Management LP | 0 | 37,194 | +37,194 | 0.00 | 0.03 | +0.03 | buy |
| IMC-Chicago, LLC | 0 | 36,468 | +36,468 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 32,886 | +32,886 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 15,469 | 30,476 | +15,007 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 30,300 | +30,300 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,972 | 29,296 | +10,324 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 58,229 | 28,972 | -29,257 | 0.01 | 0.01 | +0.00 | sell |
| AXIOM INVESTORS LLC /DE | 25,180 | 25,998 | +818 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 24,292 | +24,292 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 32,245 | 22,973 | -9,272 | 0.01 | 0.01 | -0.00 | sell |
| SG Americas Securities, LLC | 17,526 | 21,888 | +4,362 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 20,159 | +20,159 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 45,015 | 18,479 | -26,536 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 2,585 | 17,987 | +15,402 | 0.01 | 0.06 | +0.06 | buy |
| Legal & General Group Plc | 20,905 | 16,078 | -4,827 | 0.00 | 0.00 | +0.00 | sell |
| Vident Advisory, LLC | 0 | 15,444 | +15,444 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 14,920 | +14,920 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,919 | 13,592 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 13,448 | +13,448 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 12,582 | +12,582 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,712 | 12,438 | -274 | 0.00 | 0.00 | +0.00 | sell |
| Centiva Capital, LP | 4,500 | 12,291 | +7,791 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,296 | 11,310 | +4,014 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 11,095 | +11,095 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 8,985 | +8,985 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 8,523 | +8,523 | 0.00 | 0.05 | +0.05 | buy |
| Caitong International Asset Management Co., Ltd | 84,553 | 6,950 | -77,603 | 0.42 | 0.02 | -0.40 | sell |
| KLP KAPITALFORVALTNING AS | 4,500 | 6,800 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 6,266 | +6,266 | 0.00 | 0.00 | +0.00 | buy |