| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Flagship Pioneering Inc. | 12,674,120 | 12,674,120 | 0 | 21.12 | 5.22 | -15.91 | hold |
| FMR LLC | 5,396,814 | 6,047,198 | +650,384 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,302,000 | 5,842,000 | +540,000 | 0.96 | 0.89 | -0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,649,211 | 4,394,367 | +745,156 | 0.25 | 0.25 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 2,505,821 | 2,602,382 | +96,561 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 2,349,870 | 2,364,866 | +14,996 | 0.00 | 0.00 | -0.00 | buy |
| Euclidean Capital LLC | 1,573,761 | 1,573,761 | 0 | 2.30 | 1.92 | -0.38 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 795,040 | 848,172 | +53,132 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 720,720 | 720,720 | 0 | 0.12 | 0.10 | -0.02 | hold |
| STATE STREET CORP | 618,666 | 679,787 | +61,121 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 607,670 | 448,976 | -158,694 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 297,736 | 406,425 | +108,689 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 313,765 | +313,765 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 269,186 | 303,757 | +34,571 | 0.01 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 281,730 | 281,730 | 0 | 0.89 | 0.77 | -0.12 | hold |
| NORTHERN TRUST CORP | 262,430 | 275,875 | +13,445 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 182,276 | 200,013 | +17,737 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 21,523 | 180,333 | +158,810 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 118,701 | 136,108 | +17,407 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 122,889 | 122,889 | 0 | 0.11 | 0.08 | -0.03 | hold |
| PANAGORA ASSET MANAGEMENT INC | 89,295 | 115,063 | +25,768 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 126,859 | 111,859 | -15,000 | 0.16 | 0.12 | -0.04 | sell |
| SCS Capital Management LLC | 106,980 | 106,980 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Squarepoint Ops LLC | 141,580 | 103,743 | -37,837 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,363 | 103,525 | +21,162 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 0 | 102,000 | +102,000 | 0.00 | 0.36 | +0.36 | buy |
| Qube Research & Technologies Ltd | 53,257 | 81,278 | +28,021 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 30,630 | 79,944 | +49,314 | 0.10 | 0.16 | +0.06 | buy |
| Bank of New York Mellon Corp | 78,898 | 79,559 | +661 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,600 | 74,600 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 53,144 | 65,645 | +12,501 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 50,133 | 50,378 | +245 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 47,108 | 46,644 | -464 | 0.12 | 0.09 | -0.04 | sell |
| RHUMBLINE ADVISERS | 40,117 | 39,505 | -612 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 7,726 | 37,631 | +29,905 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 81,348 | 34,445 | -46,903 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 13,550 | 32,560 | +19,010 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 30,111 | +30,111 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 208,565 | 29,552 | -179,013 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 61,968 | 27,646 | -34,322 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 27,421 | 27,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 26,660 | 26,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,800 | 25,100 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,408 | 24,478 | +8,070 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 63,190 | 19,433 | -43,757 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 10,785 | 17,736 | +6,951 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,862 | 16,236 | +374 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,755 | 14,741 | -24,014 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 14,269 | 14,269 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 13,928 | 13,928 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 24,129 | 13,740 | -10,389 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,273 | 12,849 | +4,576 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 12,224 | +12,224 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,205 | +12,205 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,326 | 11,326 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 10,879 | 10,879 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Diversified Trust Co | 0 | 10,852 | +10,852 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,215 | 10,396 | +1,181 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 19,143 | 9,710 | -9,433 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 8,600 | 8,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Evelyn Partners Asset Management Ltd | 7,100 | 7,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 5,295 | +5,295 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,238 | 5,238 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 2,330 | 3,415 | +1,085 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,349 | 3,345 | +1,996 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,343 | 3,343 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,073 | 3,295 | +1,222 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,748 | 3,056 | +308 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,378 | 2,985 | -393 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 5,938 | 2,898 | -3,040 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 374 | 2,876 | +2,502 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | 1,871 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,048 | 1,801 | -247 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,111 | 1,263 | +152 | 0.00 | 0.00 | -0.00 | buy |
| Sunbelt Securities, Inc. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 364 | 864 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 847 | 488 | -359 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 310 | 294 | -16 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TFC Financial Management, Inc. | 123 | 123 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 0 | 97 | +97 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 75 | 82 | +7 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Root Financial Partners, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Wealth Preservation Advisors, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,576 | 0 | -14,576 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 16,600 | 0 | -16,600 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 28,893 | 0 | -28,893 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 10,400 | 0 | -10,400 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 10,486 | 0 | -10,486 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 132,501 | 0 | -132,501 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,662 | 0 | -15,662 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 17,219 | 0 | -17,219 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,046 | 0 | -1,046 | 0.00 | 0.00 | -0.00 | sell |