| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 5,302,000 | +5,302,000 | 0.00 | 0.85 | +0.85 | buy |
| FMR LLC | 2,691,136 | 6,383,291 | +3,692,155 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 2,518,500 | +2,518,500 | 0.00 | 0.24 | +0.24 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 544,000 | +544,000 | 0.00 | 0.08 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 280,382 | 568,470 | +288,088 | 0.02 | 0.03 | +0.01 | buy |
| Focus Partners Wealth | 107,770 | 215,690 | +107,920 | 0.01 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 448,411 | 531,110 | +82,699 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 57,500 | +57,500 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 437,664 | 482,315 | +44,651 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 43,789 | +43,789 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 41,850 | +41,850 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 23,973 | 64,850 | +40,877 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 25,738 | +25,738 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 24,207 | +24,207 | 0.00 | 0.07 | +0.07 | buy |
| Bank of New York Mellon Corp | 60,769 | 79,433 | +18,664 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 17,145 | +17,145 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 55,442 | 68,495 | +13,053 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 11,200 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 10,700 | +10,700 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 10,160 | +10,160 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,739 | 35,910 | +9,171 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 6,940 | +6,940 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,050 | 14,590 | +4,540 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 11,421 | 15,194 | +3,773 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,079 | 9,272 | +3,193 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,385 | 5,601 | +2,216 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,009 | 2,824 | +815 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,791 | 15,869 | +78 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1 | 17 | +16 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,004 | 5,015 | +11 | 0.00 | 0.00 | -0.00 | buy |
| Artal Group S.A. | 720,720 | 720,720 | 0 | 0.12 | 0.11 | -0.02 | hold |
| Ameritas Investment Partners, Inc. | 1,534 | 1,534 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WASHINGTON TRUST Co | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 45,027 | 45,027 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Flagship Pioneering Inc. | 12,674,120 | 12,674,120 | 0 | 5.58 | 8.64 | +3.06 | hold |
| Sio Capital Management, LLC | 121,672 | 121,672 | 0 | 0.28 | 0.26 | -0.02 | hold |
| Birchview Capital, LP | 320,930 | 320,930 | 0 | 1.76 | 1.71 | -0.05 | hold |
| Capital Analysts, LLC | 547 | 547 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 500,901 | 500,901 | 0 | 0.13 | 0.15 | +0.01 | hold |
| Balefire, LLC | 210 | 210 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 1,573,761 | 1,573,761 | 0 | 1.35 | 1.14 | -0.22 | hold |
| TFC Financial Management, Inc. | 123 | 123 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alta Wealth Advisors LLC | 30,032 | 30,032 | 0 | 0.10 | 0.09 | -0.02 | hold |
| Rockwood Wealth Management, LLC | 107,329 | 107,329 | 0 | 0.09 | 0.08 | -0.02 | hold |
| FIDUCIARY TRUST CO | 10,879 | 10,879 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 42,367 | 42,367 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 681 | 681 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 7 | 0 | -7 | 0.00 | 0.00 | 0.00 | sell |
| GROUP ONE TRADING LLC | 151 | 0 | -151 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,044 | 1,830 | -214 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 25,819 | 25,567 | -252 | 0.03 | 0.02 | -0.00 | sell |
| Sunbelt Securities, Inc. | 1,500 | 1,000 | -500 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 548 | 0 | -548 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,422 | 1,871 | -551 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 9,594 | 7,840 | -1,754 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 100,305 | 98,527 | -1,778 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,119 | 0 | -2,119 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 195,242 | 190,951 | -4,291 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,242 | 13,692 | -5,550 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 10,018 | 0 | -10,018 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 47,097 | 35,921 | -11,176 | 0.01 | 0.01 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,474 | 0 | -12,474 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 13,448 | 0 | -13,448 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,080 | 0 | -16,080 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 20,374 | 0 | -20,374 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 21,855 | 0 | -21,855 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 437,369 | 406,641 | -30,728 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 216,270 | 184,304 | -31,966 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 36,526 | 0 | -36,526 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 62,047 | 21,954 | -40,093 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,102,493 | 1,059,485 | -43,008 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 56,042 | 0 | -56,042 | 0.00 | 0.00 | -0.00 | sell |