| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 1,059,485 | 1,731,979 | +672,494 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,518,500 | 3,027,886 | +509,386 | 0.24 | 0.42 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 531,110 | 677,386 | +146,276 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 60,604 | +60,604 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 190,951 | 250,798 | +59,847 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 25,738 | 69,696 | +43,958 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 39,591 | +39,591 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 21,954 | 58,334 | +36,380 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 15,194 | 45,557 | +30,363 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 24,207 | 53,106 | +28,899 | 0.07 | 0.24 | +0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 43,789 | 72,216 | +28,427 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 17,145 | 44,927 | +27,782 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,692 | 39,920 | +26,228 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 482,315 | 505,945 | +23,630 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 20,549 | +20,549 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 16,944 | +16,944 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 64,850 | 81,204 | +16,354 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 10,700 | 25,236 | +14,536 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 12,776 | +12,776 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 5,601 | 18,345 | +12,744 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,966 | +10,966 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,900 | +10,900 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 10,652 | +10,652 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,940 | 15,898 | +8,958 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,495 | 75,495 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 7,840 | 12,310 | +4,470 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,762 | 13,864 | +4,102 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 14,590 | 17,380 | +2,790 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,272 | 11,883 | +2,611 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,477 | +1,477 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 57,500 | 58,500 | +1,000 | 0.01 | 0.01 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,869 | 16,667 | +798 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,015 | 5,087 | +72 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,534 | 1,534 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 5,302,000 | 5,302,000 | 0 | 0.85 | 1.44 | +0.59 | hold |
| WASHINGTON TRUST Co | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,830 | 1,830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 45,027 | 45,027 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Flagship Pioneering Inc. | 12,674,120 | 12,674,120 | 0 | 8.64 | 19.94 | +11.29 | hold |
| Sio Capital Management, LLC | 121,672 | 121,672 | 0 | 0.26 | 0.51 | +0.24 | hold |
| Birchview Capital, LP | 320,930 | 320,930 | 0 | 1.71 | 2.59 | +0.88 | hold |
| Sunbelt Securities, Inc. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 500,901 | 500,901 | 0 | 0.15 | 0.25 | +0.11 | hold |
| Euclidean Capital LLC | 1,573,761 | 1,573,761 | 0 | 1.14 | 1.62 | +0.48 | hold |
| TFC Financial Management, Inc. | 123 | 123 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockwood Wealth Management, LLC | 107,329 | 107,329 | 0 | 0.08 | 0.11 | +0.03 | hold |
| FIDUCIARY TRUST CO | 10,879 | 10,879 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | 1,871 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 42,367 | 42,367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 681 | 681 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 17 | 0 | -17 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 13,587 | 13,505 | -82 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 2,824 | 2,706 | -118 | 0.00 | 0.00 | +0.00 | sell |
| Balefire, LLC | 210 | 0 | -210 | 0.00 | 0.00 | -0.00 | sell |
| Capital Analysts, LLC | 547 | 0 | -547 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,200 | 10,560 | -640 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 35,910 | 33,335 | -2,575 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 41,850 | 37,664 | -4,186 | 0.06 | 0.08 | +0.03 | sell |
| Point72 Asset Management, L.P. | 406,641 | 399,702 | -6,939 | 0.01 | 0.01 | +0.01 | sell |
| Tower Research Capital LLC (TRC) | 10,160 | 1,421 | -8,739 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 25,567 | 13,147 | -12,420 | 0.02 | 0.04 | +0.01 | sell |
| Alta Wealth Advisors LLC | 30,032 | 15,032 | -15,000 | 0.09 | 0.06 | -0.02 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 35,921 | 18,085 | -17,836 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 79,433 | 56,347 | -23,086 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 6,383,291 | 6,333,984 | -49,307 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 184,304 | 129,331 | -54,973 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 98,527 | 39,241 | -59,286 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 215,690 | 0 | -215,690 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 544,000 | 0 | -544,000 | 0.08 | 0.00 | -0.08 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 568,470 | 0 | -568,470 | 0.03 | 0.00 | -0.03 | sell |
| Artal Group S.A. | 720,720 | 0 | -720,720 | 0.11 | 0.00 | -0.11 | sell |