| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 399,702 | 634,761 | +235,059 | 0.01 | 0.01 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,027,886 | 3,255,514 | +227,628 | 0.42 | 0.29 | -0.13 | buy |
| BlackRock, Inc. | 1,811,302 | 2,029,208 | +217,906 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 37,664 | 186,717 | +149,053 | 0.08 | 0.22 | +0.14 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129,331 | 223,780 | +94,449 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 505,945 | 567,367 | +61,422 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 10,966 | 56,531 | +45,565 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 58,334 | 92,640 | +34,306 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 69,696 | 100,367 | +30,671 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 45,557 | 74,656 | +29,099 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 20,549 | 49,643 | +29,094 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 16,944 | 41,144 | +24,200 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 25,236 | 47,736 | +22,500 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,731,979 | 1,749,660 | +17,681 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 39,241 | 55,154 | +15,913 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 15,851 | +15,851 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 72,216 | 87,069 | +14,853 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 12,946 | +12,946 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 11,788 | +11,788 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 39,920 | 51,609 | +11,689 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 10,895 | +10,895 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 10,582 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 677,386 | 682,863 | +5,477 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,883 | 15,841 | +3,958 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 33,335 | 36,384 | +3,049 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 250,798 | 253,671 | +2,873 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 12,776 | 15,617 | +2,841 | 0.03 | 0.02 | -0.00 | buy |
| HSBC HOLDINGS PLC | 16,667 | 18,728 | +2,061 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 56,347 | 58,312 | +1,965 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,853 | +1,853 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 18,345 | 20,032 | +1,687 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 60,604 | 61,598 | +994 | 0.01 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 10,652 | 11,398 | +746 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,421 | 2,104 | +683 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 680 | +680 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,864 | 14,472 | +608 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 509 | +509 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 48 | 354 | +306 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 18 | +18 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,534 | 1,534 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,302,000 | 5,302,000 | 0 | 1.44 | 0.85 | -0.60 | hold |
| WASHINGTON TRUST Co | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,830 | 1,830 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,380 | 17,380 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 45,027 | 45,027 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Flagship Pioneering Inc. | 12,674,120 | 12,674,120 | 0 | 19.94 | 17.90 | -2.04 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 18,085 | 18,085 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 121,672 | 121,672 | 0 | 0.51 | 0.16 | -0.35 | hold |
| Sunbelt Securities, Inc. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 500,901 | 500,901 | 0 | 0.25 | 0.14 | -0.12 | hold |
| Russell Investments Group, Ltd. | 1,477 | 1,477 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 1,573,761 | 1,573,761 | 0 | 1.62 | 1.01 | -0.61 | hold |
| TFC Financial Management, Inc. | 123 | 123 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alta Wealth Advisors LLC | 15,032 | 15,032 | 0 | 0.06 | 0.03 | -0.03 | hold |
| Rockwood Wealth Management, LLC | 107,329 | 107,329 | 0 | 0.11 | 0.05 | -0.06 | hold |
| Siren, L.L.C. | 720,720 | 720,720 | 0 | 0.34 | 0.15 | -0.19 | hold |
| FIDUCIARY TRUST CO | 10,879 | 10,879 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,706 | 2,706 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | 1,871 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 75,495 | 75,495 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 681 | 681 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 5,087 | 5,087 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 12,310 | 12,310 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,560 | 10,295 | -265 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 13,505 | 12,557 | -948 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 42,367 | 35,784 | -6,583 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 320,930 | 310,930 | -10,000 | 2.59 | 1.19 | -1.39 | sell |
| ZACKS INVESTMENT MANAGEMENT | 10,300 | 0 | -10,300 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 44,927 | 34,048 | -10,879 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 10,900 | 0 | -10,900 | 0.01 | 0.00 | -0.01 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 13,147 | 0 | -13,147 | 0.04 | 0.00 | -0.04 | sell |
| MetLife Investment Management, LLC | 15,898 | 0 | -15,898 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 53,106 | 34,576 | -18,530 | 0.24 | 0.09 | -0.15 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 58,500 | 33,500 | -25,000 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,591 | 0 | -39,591 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 81,204 | 0 | -81,204 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 6,333,984 | 5,689,719 | -644,265 | 0.00 | 0.00 | -0.00 | sell |