| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AMERIPRISE FINANCIAL INC | 0 | 607,670 | +607,670 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,255,514 | 3,649,211 | +393,697 | 0.24 | 0.25 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 182,276 | +182,276 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 118,236 | 297,736 | +179,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 36,612 | 141,580 | +104,968 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,259,948 | 2,349,870 | +89,922 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 184,063 | 269,186 | +85,123 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 66,389 | 132,501 | +66,112 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 53,257 | +53,257 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 34,308 | 81,348 | +47,040 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 72,447 | 118,701 | +46,254 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 2,462,488 | 2,505,821 | +43,333 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 11,441 | 47,108 | +35,667 | 0.04 | 0.12 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 178,791 | 208,565 | +29,774 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,899,457 | 1,928,992 | +29,535 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 28,893 | +28,893 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 24,129 | +24,129 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 65,337 | 89,295 | +23,958 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 17,219 | +17,219 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 16,600 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,662 | +15,662 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,474 | 38,755 | +14,281 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 13,928 | +13,928 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 12,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 3,169 | 14,269 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 10,785 | +10,785 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 10,486 | +10,486 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 10,400 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 7,726 | +7,726 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 58,486 | 63,190 | +4,704 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 3,900 | 8,600 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,560 | 27,421 | +1,861 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,103 | 8,273 | +1,170 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,185 | 2,748 | +563 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,378 | 15,862 | +484 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,542 | 5,938 | +396 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 374 | +374 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 681 | 1,046 | +365 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,832 | 2,048 | +216 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 255 | 364 | +109 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 755 | 847 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,343 | 3,343 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 5,302,000 | 5,302,000 | 0 | 1.05 | 0.96 | -0.09 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,600 | 74,600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 26,660 | 26,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCS Capital Management LLC | 106,980 | 106,980 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DAFNA Capital Management LLC | 126,859 | 126,859 | 0 | 0.15 | 0.16 | +0.01 | hold |
| Flagship Pioneering Inc. | 12,674,120 | 12,674,120 | 0 | 21.18 | 21.12 | -0.06 | hold |
| Sio Capital Management, LLC | 122,889 | 122,889 | 0 | 0.15 | 0.11 | -0.04 | hold |
| Birchview Capital, LP | 281,730 | 281,730 | 0 | 1.04 | 0.89 | -0.15 | hold |
| EverSource Wealth Advisors, LLC | 75 | 75 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Euclidean Capital LLC | 1,573,761 | 1,573,761 | 0 | 3.23 | 2.30 | -0.93 | hold |
| TFC Financial Management, Inc. | 123 | 123 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 310 | 310 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 50,133 | 50,133 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 720,720 | 720,720 | 0 | 0.14 | 0.12 | -0.02 | hold |
| Police & Firemen's Retirement System of New Jersey | 11,326 | 11,326 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Evelyn Partners Asset Management Ltd | 7,100 | 7,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FIDUCIARY TRUST CO | 10,879 | 10,879 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 3,378 | 3,378 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,408 | 16,408 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | 1,871 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 5,238 | 5,238 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sunbelt Securities, Inc. | 1,001 | 1,000 | -1 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 11 | 5 | -6 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,352 | 2,330 | -22 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,192 | 1,111 | -81 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 1,678 | 1,349 | -329 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,504 | 2,073 | -431 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 451 | 0 | -451 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 519 | 0 | -519 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,909 | 9,215 | -694 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 1,549 | 0 | -1,549 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 80,477 | 78,898 | -1,579 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 16,197 | 14,576 | -1,621 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 21,282 | 19,143 | -2,139 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 43,723 | 40,117 | -3,606 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 17,778 | 13,550 | -4,228 | 0.00 | 0.00 | -0.00 | sell |
| Alta Wealth Advisors LLC | 10,032 | 0 | -10,032 | 0.02 | 0.00 | -0.02 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 11,873 | 0 | -11,873 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 808,488 | 795,040 | -13,448 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 15,228 | 0 | -15,228 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 98,184 | 82,363 | -15,821 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 637,148 | 618,666 | -18,482 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 71,644 | 53,144 | -18,500 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 50,000 | 30,630 | -19,370 | 0.17 | 0.10 | -0.07 | sell |
| NORTHERN TRUST CORP | 284,301 | 262,430 | -21,871 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 22,025 | 0 | -22,025 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 5,474,491 | 5,396,814 | -77,677 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 108,596 | 21,523 | -87,073 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 161,140 | 0 | -161,140 | 0.04 | 0.00 | -0.04 | sell |
| Point72 Asset Management, L.P. | 371,033 | 61,968 | -309,065 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 500,901 | 0 | -500,901 | 0.10 | 0.00 | -0.10 | sell |