| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Column Group LLC | 810,088 | 1,499,773 | +689,685 | 20.85 | 39.54 | +18.69 | buy |
| VR Adviser, LLC | 0 | 632,931 | +632,931 | 0.00 | 0.63 | +0.63 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 282,580 | 679,130 | +396,550 | 0.05 | 0.13 | +0.08 | buy |
| 5AM Venture Management, LLC | 0 | 310,000 | +310,000 | 0.00 | 1.37 | +1.37 | buy |
| Vivo Capital, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.40 | +0.40 | buy |
| Samsara BioCapital, LLC | 0 | 241,400 | +241,400 | 0.00 | 0.50 | +0.50 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 204,934 | +204,934 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 170,000 | +170,000 | 0.00 | 2.30 | +2.30 | buy |
| Stonepine Capital Management, LLC | 137,200 | 285,782 | +148,582 | 1.59 | 3.24 | +1.65 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 108,333 | +108,333 | 0.00 | 0.00 | +0.00 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 0 | 83,333 | +83,333 | 0.00 | 0.00 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 44,978 | +44,978 | 0.00 | 0.25 | +0.25 | buy |
| Nantahala Capital Management, LLC | 196,023 | 229,527 | +33,504 | 0.20 | 0.22 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 64,653 | 88,653 | +24,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 65,135 | 68,026 | +2,891 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 22,391 | 25,261 | +2,870 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,526 | 14,226 | +700 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 283 | 402 | +119 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,247 | 8,320 | +73 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANTOR FITZGERALD, L. P. | 70,824 | 70,824 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 466,666 | 466,666 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.06 | 0.05 | -0.01 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,614 | 24,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 20,718 | 20,718 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trustees of Columbia University in the City of New York | 47,930 | 47,930 | 0 | 0.11 | 0.09 | -0.02 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.17 | 0.38 | +0.21 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.59 | 0.33 | -0.26 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 41,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CLEAR STREET LLC | 346 | 100 | -246 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 11,493 | 0 | -11,493 | 0.00 | 0.00 | 0.00 | sell |
| ARMISTICE CAPITAL, LLC | 75,694 | 0 | -75,694 | 0.03 | 0.00 | -0.03 | sell |
| STEMPOINT CAPITAL LP | 350,573 | 240,826 | -109,747 | 1.26 | 0.90 | -0.36 | sell |