| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 1,473,101 | +1,473,101 | 0.00 | 1.23 | +1.23 | buy |
| Boxer Capital Management, LLC | 416,150 | 766,318 | +350,168 | 2.06 | 2.93 | +0.87 | buy |
| Vestal Point Capital, LP | 0 | 338,611 | +338,611 | 0.00 | 0.28 | +0.28 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 229,393 | +229,393 | 0.00 | 0.13 | +0.13 | buy |
| Ikarian Capital, LLC | 65,788 | 173,107 | +107,319 | 0.19 | 0.72 | +0.53 | buy |
| AMERIPRISE FINANCIAL INC | 65,688 | 159,711 | +94,023 | 0.00 | 0.00 | +0.00 | buy |
| Column Group LLC | 1,851,350 | 1,916,950 | +65,600 | 50.54 | 55.45 | +4.91 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 41,666 | +41,666 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 39,482 | +39,482 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 18,307 | 47,299 | +28,992 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 22,626 | 49,126 | +26,500 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 21,247 | +21,247 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 14,740 | 35,469 | +20,729 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 14,516 | +14,516 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 190,489 | 203,888 | +13,399 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,155 | +12,155 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 721,266 | 731,138 | +9,872 | 0.01 | 0.02 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 8,653 | +8,653 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 10,939 | 18,930 | +7,991 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,520 | 7,325 | +4,805 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 24,326 | 27,726 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 4,359 | 7,143 | +2,784 | 0.05 | 0.08 | +0.03 | buy |
| BARCLAYS PLC | 0 | 1,888 | +1,888 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 26,118 | 27,851 | +1,733 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 1,977 | 3,085 | +1,108 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,500 | 2,500 | +1,000 | 0.00 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 10,558 | 11,071 | +513 | 0.00 | 0.00 | 0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 25,823 | 25,851 | +28 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | 88,653 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 442,052 | 442,052 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.03 | 0.04 | +0.02 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 23,557 | 23,557 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EcoR1 Capital, LLC | 4,444 | 4,444 | 0 | 0.00 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 632,931 | 632,931 | 0 | 0.71 | 0.69 | -0.02 | hold |
| Vivo Capital, LLC | 260,000 | 260,000 | 0 | 0.38 | 0.63 | +0.25 | hold |
| 5AM Venture Management, LLC | 387,500 | 387,500 | 0 | 2.75 | 3.13 | +0.38 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.54 | 0.65 | +0.11 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.11 | 0.13 | +0.02 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 83,333 | 83,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,508 | 1,508 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 1,062 | 0 | -1,062 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 66,995 | 65,849 | -1,146 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 13,530 | 12,265 | -1,265 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 230,572 | 227,848 | -2,724 | 0.02 | 0.03 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 178,415 | 172,847 | -5,568 | 2.74 | 3.58 | +0.84 | sell |
| 683 Capital Management, LLC | 41,999 | 33,000 | -8,999 | 0.08 | 0.09 | +0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 157,323 | 144,255 | -13,068 | 0.51 | 0.50 | -0.02 | sell |
| IEQ CAPITAL, LLC | 13,471 | 0 | -13,471 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 13,700 | 0 | -13,700 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 14,802 | 0 | -14,802 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 18,921 | 0 | -18,921 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 27,622 | 0 | -27,622 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 99,560 | 71,697 | -27,863 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 29,608 | 0 | -29,608 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 95,286 | 58,624 | -36,662 | 0.12 | 0.11 | -0.01 | sell |
| Walleye Capital LLC | 41,041 | 0 | -41,041 | 0.01 | 0.00 | -0.01 | sell |
| BRAIDWELL LP | 470,000 | 396,100 | -73,900 | 0.34 | 0.38 | +0.05 | sell |
| Schonfeld Strategic Advisors LLC | 74,645 | 0 | -74,645 | 0.01 | 0.00 | -0.01 | sell |
| Stonepine Capital Management, LLC | 113,631 | 33,005 | -80,626 | 2.03 | 0.85 | -1.19 | sell |
| STEMPOINT CAPITAL LP | 619,766 | 525,639 | -94,127 | 2.17 | 2.59 | +0.41 | sell |
| Nantahala Capital Management, LLC | 229,527 | 0 | -229,527 | 0.31 | 0.00 | -0.31 | sell |