| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| HHLR ADVISORS, LTD. | 0 | 384,273 | +384,273 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 282,580 | +282,580 | 0.00 | 0.04 | +0.04 | buy |
| Column Group LLC | 616,540 | 810,088 | +193,548 | 6.03 | 12.44 | +6.41 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 190,000 | +190,000 | 0.00 | 0.05 | +0.05 | buy |
| Nantahala Capital Management, LLC | 0 | 187,206 | +187,206 | 0.00 | 0.21 | +0.21 | buy |
| STEMPOINT CAPITAL LP | 0 | 143,510 | +143,510 | 0.00 | 0.46 | +0.46 | buy |
| Hudson Bay Capital Management LP | 0 | 98,705 | +98,705 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 66,084 | +66,084 | 0.00 | 0.66 | +0.66 | buy |
| UBS Group AG | 0 | 12,027 | +12,027 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,473 | 18,708 | +7,235 | 0.00 | 0.00 | +0.00 | buy |
| CLEAR STREET LLC | 166 | 266 | +100 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANTOR FITZGERALD, L. P. | 35,200 | 35,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 466,666 | 466,666 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.07 | 0.04 | -0.03 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,614 | 24,614 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 20,376 | 20,376 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 17,220 | 17,220 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Altium Capital Management LLC | 82,233 | 82,233 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.18 | 0.12 | -0.06 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 184 | 0 | -184 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 450 | 0 | -450 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 61,511 | 60,835 | -676 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,726 | 12,426 | -1,300 | 0.00 | 0.00 | -0.00 | sell |