| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STEMPOINT CAPITAL LP | 240,826 | 686,539 | +445,713 | 0.90 | 1.98 | +1.08 | buy |
| VANGUARD GROUP INC | 68,026 | 218,950 | +150,924 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 140,000 | +140,000 | 0.00 | 0.04 | +0.04 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 30,129 | +30,129 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 285,782 | 306,029 | +20,247 | 3.24 | 2.70 | -0.55 | buy |
| BlackRock, Inc. | 8,320 | 15,483 | +7,163 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 25,261 | 30,963 | +5,702 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,226 | 14,626 | +400 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANTOR FITZGERALD, L. P. | 70,824 | 70,824 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | 88,653 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Hudson Bay Capital Management LP | 20,718 | 20,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 47,930 | 47,930 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 229,527 | 229,527 | 0 | 0.22 | 0.15 | -0.08 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 170,000 | 170,000 | 0 | 2.30 | 2.12 | -0.18 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.05 | 0.04 | -0.01 | hold |
| VR Adviser, LLC | 632,931 | 632,931 | 0 | 0.63 | 0.42 | -0.20 | hold |
| Vivo Capital, LLC | 260,000 | 260,000 | 0 | 0.40 | 0.24 | -0.16 | hold |
| CLEAR STREET LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 241,400 | 241,400 | 0 | 0.50 | 0.44 | -0.06 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 310,000 | 310,000 | 0 | 1.37 | 1.07 | -0.30 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.38 | 0.26 | -0.13 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Column Group LLC | 1,499,773 | 1,499,773 | 0 | 39.54 | 20.40 | -19.14 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.33 | 0.10 | -0.23 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 83,333 | 83,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 41,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 402 | 216 | -186 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGER MANAGEMENT, LLC | 466,666 | 442,052 | -24,614 | 0.01 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,614 | 0 | -24,614 | 0.00 | 0.00 | -0.00 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 44,978 | 0 | -44,978 | 0.25 | 0.00 | -0.25 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 679,130 | 602,626 | -76,504 | 0.13 | 0.09 | -0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 204,934 | 67,566 | -137,368 | 0.02 | 0.00 | -0.02 | sell |