| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 664,272 | +664,272 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 27,851 | 394,864 | +367,013 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 766,318 | 1,105,683 | +339,365 | 2.93 | 2.03 | -0.90 | buy |
| PERCEPTIVE ADVISORS LLC | 229,393 | 503,985 | +274,592 | 0.13 | 0.20 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 65,849 | 201,652 | +135,803 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 27,726 | 133,084 | +105,358 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 25,851 | 113,531 | +87,680 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 525,639 | 602,798 | +77,159 | 2.59 | 2.39 | -0.20 | buy |
| NORTHERN TRUST CORP | 12,265 | 63,609 | +51,344 | 0.00 | 0.00 | +0.00 | buy |
| Ellsworth Advisors, LLC | 0 | 39,283 | +39,283 | 0.00 | 0.14 | +0.14 | buy |
| Walleye Capital LLC | 0 | 38,832 | +38,832 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 39,482 | 71,119 | +31,637 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 31,295 | +31,295 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 16,828 | +16,828 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 16,297 | +16,297 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 16,297 | +16,297 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 15,379 | +15,379 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 9,840 | +9,840 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 9,780 | +9,780 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 8,130 | +8,130 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 21,247 | 29,229 | +7,982 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 7,302 | +7,302 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 6,698 | +6,698 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 27,741 | +6,026 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 4,699 | +4,699 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 3,455 | +3,455 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,381 | +3,381 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 2,166 | +2,166 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,500 | 3,650 | +1,150 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 203,888 | 205,032 | +1,144 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 0 | 715 | +715 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,325 | 8,029 | +704 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 666 | +666 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 172,847 | 173,395 | +548 | 3.58 | 3.14 | -0.45 | buy |
| Tower Research Capital LLC (TRC) | 0 | 428 | +428 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 348 | +348 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | 88,653 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 442,052 | 442,052 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 3,085 | 3,085 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.04 | 0.06 | +0.02 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 4,444 | 4,444 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 632,931 | 632,931 | 0 | 0.69 | 0.50 | -0.19 | hold |
| Vivo Capital, LLC | 260,000 | 260,000 | 0 | 0.63 | 0.62 | -0.01 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.65 | 0.52 | -0.13 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Column Group LLC | 1,916,950 | 1,916,950 | 0 | 55.45 | 56.46 | +1.02 | hold |
| TCG Crossover Management, LLC | 1,473,101 | 1,473,101 | 0 | 1.23 | 0.92 | -0.31 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 83,333 | 83,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.13 | 0.08 | -0.05 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 41,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,508 | 1,508 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 29 | 0 | -29 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1,888 | 1,767 | -121 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 396,100 | 390,753 | -5,347 | 0.38 | 0.38 | -0.01 | sell |
| Persistent Asset Partners Ltd | 7,143 | 0 | -7,143 | 0.08 | 0.00 | -0.08 | sell |
| Hudson Bay Capital Management LP | 8,653 | 0 | -8,653 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 23,557 | 13,557 | -10,000 | 0.01 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 58,624 | 47,777 | -10,847 | 0.11 | 0.07 | -0.04 | sell |
| Virtu Financial LLC | 11,071 | 0 | -11,071 | 0.00 | 0.00 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 12,000 | 0 | -12,000 | 0.02 | 0.00 | -0.02 | sell |
| HRT FINANCIAL LP | 12,155 | 0 | -12,155 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 14,516 | 0 | -14,516 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 18,930 | 0 | -18,930 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 33,000 | 0 | -33,000 | 0.09 | 0.00 | -0.09 | sell |
| Stonepine Capital Management, LLC | 33,005 | 0 | -33,005 | 0.85 | 0.00 | -0.85 | sell |
| Vestal Point Capital, LP | 338,611 | 304,669 | -33,942 | 0.28 | 0.18 | -0.09 | sell |
| CITADEL ADVISORS LLC | 35,469 | 0 | -35,469 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 49,126 | 12,374 | -36,752 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 47,299 | 0 | -47,299 | 0.03 | 0.00 | -0.03 | sell |
| FRED ALGER MANAGEMENT, LLC | 71,697 | 24,004 | -47,693 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 731,138 | 683,079 | -48,059 | 0.02 | 0.01 | -0.00 | sell |
| 5AM Venture Management, LLC | 387,500 | 271,250 | -116,250 | 3.13 | 2.44 | -0.69 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 144,255 | 0 | -144,255 | 0.50 | 0.00 | -0.50 | sell |
| AMERIPRISE FINANCIAL INC | 159,711 | 0 | -159,711 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 173,107 | 0 | -173,107 | 0.72 | 0.00 | -0.72 | sell |
| Woodline Partners LP | 227,848 | 0 | -227,848 | 0.03 | 0.00 | -0.03 | sell |