| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 0 | 216,540 | +216,540 | 0.00 | 1.00 | +1.00 | buy |
| Monashee Investment Management LLC | 0 | 82,986 | +82,986 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 66,084 | 110,000 | +43,916 | 0.66 | 0.83 | +0.17 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 41,666 | +41,666 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 143,510 | 182,918 | +39,408 | 0.46 | 0.66 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 21,715 | +21,715 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 10,930 | +10,930 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 60,835 | 65,135 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 12,426 | 13,826 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 455 | +455 | 0.00 | 0.00 | +0.00 | buy |
| CLEAR STREET LLC | 266 | 346 | +80 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANTOR FITZGERALD, L. P. | 35,200 | 35,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 466,666 | 466,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.04 | 0.05 | +0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 282,580 | 282,580 | 0 | 0.04 | 0.04 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,614 | 24,614 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 20,376 | 20,376 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 187,206 | 187,206 | 0 | 0.21 | 0.19 | -0.02 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Altium Capital Management LLC | 82,233 | 82,233 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.12 | 0.12 | -0.00 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Column Group LLC | 810,088 | 810,088 | 0 | 12.44 | 13.95 | +1.50 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 18,708 | 17,761 | -947 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 12,027 | 0 | -12,027 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 17,220 | 0 | -17,220 | 0.00 | 0.00 | 0.00 | sell |
| ARMISTICE CAPITAL, LLC | 190,000 | 139,000 | -51,000 | 0.05 | 0.04 | -0.01 | sell |
| Hudson Bay Capital Management LP | 98,705 | 20,718 | -77,987 | 0.00 | 0.00 | -0.00 | sell |
| HHLR ADVISORS, LTD. | 384,273 | 0 | -384,273 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 648,285 | 0 | -648,285 | 0.00 | 0.00 | -0.00 | sell |