| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 109,769 | +109,769 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 76,997 | +76,997 | 0.00 | 0.08 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 70,732 | +70,732 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 69,024 | +69,024 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 48,193 | +48,193 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 218,950 | 266,418 | +47,468 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 686,539 | 713,463 | +26,924 | 1.98 | 1.85 | -0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 30,963 | 54,527 | +23,564 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 13,326 | +13,326 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 170,000 | 178,415 | +8,415 | 2.12 | 2.38 | +0.25 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,626 | 14,726 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | 88,653 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 442,052 | 442,052 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.05 | 0.08 | +0.03 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 602,626 | 602,626 | 0 | 0.09 | 0.10 | +0.00 | hold |
| Hudson Bay Capital Management LP | 20,718 | 20,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 47,930 | 47,930 | 0 | 0.06 | 0.09 | +0.03 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 229,527 | 229,527 | 0 | 0.15 | 0.18 | +0.04 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.04 | 0.04 | +0.01 | hold |
| VR Adviser, LLC | 632,931 | 632,931 | 0 | 0.42 | 0.46 | +0.03 | hold |
| Vivo Capital, LLC | 260,000 | 260,000 | 0 | 0.24 | 0.27 | +0.03 | hold |
| Samsara BioCapital, LLC | 241,400 | 241,400 | 0 | 0.44 | 0.41 | -0.04 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 310,000 | 310,000 | 0 | 1.07 | 1.46 | +0.40 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.26 | 0.47 | +0.22 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Column Group LLC | 1,499,773 | 1,499,773 | 0 | 20.40 | 23.88 | +3.48 | hold |
| BRAIDWELL LP | 140,000 | 140,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 83,333 | 83,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.10 | 0.09 | -0.01 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 41,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 216 | 0 | -216 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 15,483 | 13,743 | -1,740 | 0.00 | 0.00 | +0.00 | sell |
| Monashee Investment Management LLC | 30,129 | 0 | -30,129 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 306,029 | 250,146 | -55,883 | 2.70 | 2.62 | -0.07 | sell |
| ARMISTICE CAPITAL, LLC | 60,000 | 0 | -60,000 | 0.02 | 0.00 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 67,566 | 0 | -67,566 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 70,824 | 0 | -70,824 | 0.00 | 0.00 | -0.00 | sell |