| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LMR Partners LLP | 0 | 648,285 | +648,285 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 182,918 | 350,573 | +167,655 | 0.66 | 1.26 | +0.60 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 0 | 133,207 | +133,207 | 0.00 | 0.59 | +0.59 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 64,653 | +64,653 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 35,200 | 70,824 | +35,624 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 110,000 | 137,200 | +27,200 | 0.83 | 1.59 | +0.76 | buy |
| HRT FINANCIAL LP | 0 | 11,493 | +11,493 | 0.00 | 0.00 | 0.00 | buy |
| Nantahala Capital Management, LLC | 187,206 | 196,023 | +8,817 | 0.19 | 0.20 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 17,761 | 22,391 | +4,630 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 8,211 | 8,247 | +36 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VANGUARD GROUP INC | 65,135 | 65,135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 466,666 | 466,666 | 0 | 0.00 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 281 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 52,130 | 0 | 0.05 | 0.06 | +0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 282,580 | 282,580 | 0 | 0.04 | 0.05 | +0.01 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,614 | 24,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 20,718 | 20,718 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trustees of Columbia University in the City of New York | 47,930 | 47,930 | 0 | 0.95 | 0.11 | -0.84 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EcoR1 Capital, LLC | 66,665 | 66,665 | 0 | 0.03 | 0.04 | +0.01 | hold |
| CLEAR STREET LLC | 346 | 346 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 99,999 | 99,999 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.12 | 0.17 | +0.05 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Column Group LLC | 810,088 | 810,088 | 0 | 13.95 | 20.85 | +6.91 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 41,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 455 | 283 | -172 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,826 | 13,526 | -300 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 20,376 | 10,188 | -10,188 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 10,930 | 0 | -10,930 | 0.00 | 0.00 | -0.00 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 29,999 | 0 | -29,999 | 0.26 | 0.00 | -0.26 | sell |
| ARMISTICE CAPITAL, LLC | 139,000 | 75,694 | -63,306 | 0.04 | 0.03 | -0.02 | sell |
| Altium Capital Management LLC | 82,233 | 0 | -82,233 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 82,986 | 0 | -82,986 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 108,333 | 0 | -108,333 | 0.00 | 0.00 | -0.00 | sell |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 216,540 | 0 | -216,540 | 1.00 | 0.00 | -1.00 | sell |