| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 109,769 | 721,266 | +611,497 | 0.00 | 0.01 | +0.01 | buy |
| Boxer Capital Management, LLC | 0 | 416,150 | +416,150 | 0.00 | 2.06 | +2.06 | buy |
| Column Group LLC | 1,499,773 | 1,851,350 | +351,577 | 23.88 | 50.54 | +26.66 | buy |
| BRAIDWELL LP | 140,000 | 470,000 | +330,000 | 0.05 | 0.34 | +0.29 | buy |
| Woodline Partners LP | 48,193 | 230,572 | +182,379 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 157,323 | +157,323 | 0.00 | 0.51 | +0.51 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 70,732 | 190,489 | +119,757 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 99,560 | +99,560 | 0.00 | 0.01 | +0.01 | buy |
| 5AM Venture Management, LLC | 310,000 | 387,500 | +77,500 | 1.46 | 2.75 | +1.29 | buy |
| Ikarian Capital, LLC | 0 | 65,788 | +65,788 | 0.00 | 0.19 | +0.19 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 65,688 | +65,688 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 266,418 | 319,236 | +52,818 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 41,999 | +41,999 | 0.00 | 0.08 | +0.08 | buy |
| Walleye Capital LLC | 0 | 41,041 | +41,041 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 29,608 | +29,608 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 27,622 | +27,622 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 25,823 | +25,823 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 23,557 | +23,557 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 18,921 | +18,921 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 18,307 | +18,307 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 76,997 | 95,286 | +18,289 | 0.08 | 0.12 | +0.04 | buy |
| Quadrature Capital Ltd | 0 | 14,802 | +14,802 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 14,740 | +14,740 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 13,700 | +13,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 13,530 | +13,530 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 13,471 | +13,471 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 54,527 | 66,995 | +12,468 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 13,743 | 26,118 | +12,375 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,326 | 24,326 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 10,939 | +10,939 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,558 | +10,558 | 0.00 | 0.00 | 0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,726 | 22,626 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 69,024 | 74,645 | +5,621 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 4,359 | +4,359 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,520 | +2,520 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 1,977 | +1,977 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,508 | +1,508 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,062 | +1,062 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,000 | 1,500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | 88,653 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 442,052 | 442,052 | 0 | 0.00 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 833,333 | 833,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 33,333 | 33,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 10,188 | 10,188 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 229,527 | 229,527 | 0 | 0.18 | 0.31 | +0.13 | hold |
| ArrowMark Colorado Holdings LLC | 108,333 | 108,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 55,123 | 55,123 | 0 | 0.01 | 0.03 | +0.01 | hold |
| LMR Partners LLP | 648,285 | 648,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 178,415 | 178,415 | 0 | 2.38 | 2.74 | +0.36 | hold |
| VR Adviser, LLC | 632,931 | 632,931 | 0 | 0.46 | 0.71 | +0.25 | hold |
| Vivo Capital, LLC | 260,000 | 260,000 | 0 | 0.27 | 0.38 | +0.11 | hold |
| Euclidean Capital LLC | 87,696 | 87,696 | 0 | 0.47 | 0.54 | +0.06 | hold |
| Euclidean Capital LLC | 170,833 | 170,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Boxer Capital Management, LLC | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | 133,207 | 0 | 0.09 | 0.11 | +0.01 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 83,333 | 83,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | 21,715 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 281 | 0 | -281 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 20,718 | 0 | -20,718 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,666 | 0 | -41,666 | 0.00 | 0.00 | -0.00 | sell |
| Trustees of Columbia University in the City of New York | 47,930 | 0 | -47,930 | 0.09 | 0.00 | -0.09 | sell |
| Board of Trustees of The Leland Stanford Junior University | 52,130 | 0 | -52,130 | 0.08 | 0.00 | -0.08 | sell |
| EcoR1 Capital, LLC | 66,665 | 4,444 | -62,221 | 0.04 | 0.00 | -0.04 | sell |
| STEMPOINT CAPITAL LP | 713,463 | 619,766 | -93,697 | 1.85 | 2.17 | +0.32 | sell |
| Samsara BioCapital, LLC | 99,999 | 0 | -99,999 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 250,146 | 113,631 | -136,515 | 2.62 | 2.03 | -0.59 | sell |
| Samsara BioCapital, LLC | 241,400 | 0 | -241,400 | 0.41 | 0.00 | -0.41 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 602,626 | 0 | -602,626 | 0.10 | 0.00 | -0.10 | sell |