| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,720,188 | 8,861,171 | +2,140,983 | 0.01 | 0.02 | +0.01 | buy |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 7.19 | 11.72 | +4.53 | hold |
| BlackRock, Inc. | 5,637,684 | 6,843,087 | +1,205,403 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 4,622,151 | 4,622,151 | 0 | 2.18 | 2.69 | +0.51 | hold |
| Vestal Point Capital, LP | 3,603,465 | 4,600,000 | +996,535 | 1.66 | 2.60 | +0.94 | buy |
| BVF INC/IL | 4,460,886 | 4,460,886 | 0 | 2.34 | 2.76 | +0.42 | hold |
| BAKER BROS. ADVISORS LP | 4,345,736 | 4,345,736 | 0 | 0.41 | 0.53 | +0.12 | hold |
| STATE STREET CORP | 3,353,980 | 3,731,416 | +377,436 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,226,809 | 3,549,539 | -677,270 | 1.89 | 1.81 | -0.08 | sell |
| Versant Venture Management, LLC | 3,180,780 | 3,180,780 | 0 | 37.00 | 47.34 | +10.33 | hold |
| BRAIDWELL LP | 3,206,574 | 2,451,562 | -755,012 | 1.76 | 2.19 | +0.43 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,540,812 | 1,864,113 | +323,301 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 2,809,647 | 1,622,846 | -1,186,801 | 0.02 | 0.02 | -0.01 | sell |
| MARSHALL WACE, LLP | 1,433,152 | 1,593,600 | +160,448 | 0.03 | 0.03 | +0.01 | buy |
| Aisling Capital Management LP | 1,555,664 | 1,555,664 | 0 | 5.37 | 7.98 | +2.61 | hold |
| Bellevue Group AG | 1,250,000 | 1,190,000 | -60,000 | 0.49 | 0.61 | +0.12 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,041,372 | 1,177,488 | +136,116 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 1,176,928 | 1,161,081 | -15,847 | 1.50 | 1.71 | +0.22 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,002,040 | 1,108,295 | -893,745 | 3.88 | 2.98 | -0.90 | sell |
| Frazier Life Sciences Management, L.P. | 1,000,000 | 1,000,000 | 0 | 0.42 | 0.53 | +0.10 | hold |
| GOLDMAN SACHS GROUP INC | 1,001,527 | 998,253 | -3,274 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 74,496 | 962,884 | +888,388 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 1,024,304 | 934,414 | -89,890 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 684,063 | 789,545 | +105,482 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 304,237 | 761,153 | +456,916 | 0.35 | 0.87 | +0.52 | buy |
| Opaleye Management Inc. | 0 | 745,000 | +745,000 | 0.00 | 1.63 | +1.63 | buy |
| NORTHERN TRUST CORP | 826,624 | 652,087 | -174,537 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 651,993 | 651,993 | 0 | 0.67 | 0.95 | +0.28 | hold |
| FIRST TRUST ADVISORS LP | 0 | 647,796 | +647,796 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 616,310 | +616,310 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 546,689 | 616,310 | +69,621 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 615,287 | +615,287 | 0.00 | 3.48 | +3.48 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 528,698 | 552,566 | +23,868 | 0.17 | 0.24 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 658,483 | 520,648 | -137,835 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 505,000 | 505,000 | 0 | 0.74 | 0.88 | +0.14 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 450,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 31,977 | 405,529 | +373,552 | 0.01 | 0.17 | +0.16 | buy |
| AMERIPRISE FINANCIAL INC | 35,997 | 383,335 | +347,338 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 684,275 | 372,474 | -311,801 | 0.28 | 0.01 | -0.27 | sell |
| Fisher Asset Management, LLC | 314,862 | 363,520 | +48,658 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 392,227 | 352,857 | -39,370 | 0.01 | 0.01 | +0.00 | sell |
| Empowered Funds, LLC | 305,398 | 329,266 | +23,868 | 0.03 | 0.04 | +0.01 | buy |
| Duquesne Family Office LLC | 0 | 297,600 | +297,600 | 0.00 | 0.17 | +0.17 | buy |
| TD ASSET MANAGEMENT INC | 286,978 | 285,936 | -1,042 | 0.00 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 387,542 | 254,561 | -132,981 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 204,687 | 222,521 | +17,834 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 216,792 | +216,792 | 0.00 | 0.15 | +0.15 | buy |
| ADAR1 Capital Management, LLC | 215,752 | 216,752 | +1,000 | 0.21 | 0.25 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 128,792 | 207,427 | +78,635 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 152,620 | 200,833 | +48,213 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 256,731 | 198,895 | -57,836 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,801 | 191,877 | -17,924 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 199,722 | 188,833 | -10,889 | 0.00 | 0.00 | +0.00 | sell |
| Casdin Capital, LLC | 186,014 | 186,014 | 0 | 0.23 | 0.23 | -0.01 | hold |
| D. E. Shaw & Co., Inc. | 66,327 | 172,053 | +105,726 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 154,658 | 168,512 | +13,854 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 120,872 | 166,758 | +45,886 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 254,518 | 163,571 | -90,947 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 82,339 | 156,633 | +74,294 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 153,544 | +153,544 | 0.00 | 0.64 | +0.64 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,300 | 140,923 | +121,623 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 179,484 | 137,115 | -42,369 | 1.74 | 2.05 | +0.31 | sell |
| CITIGROUP INC | 14,575 | 129,467 | +114,892 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 121,121 | +121,121 | 0.00 | 0.03 | +0.03 | buy |
| Trexquant Investment LP | 49,179 | 115,363 | +66,184 | 0.01 | 0.02 | +0.01 | buy |
| Caption Management, LLC | 0 | 112,322 | +112,322 | 0.00 | 0.10 | +0.10 | buy |
| Atom Investors LP | 194,476 | 111,012 | -83,464 | 0.23 | 0.24 | +0.01 | sell |
| Jain Global LLC | 0 | 110,647 | +110,647 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 379,100 | 102,500 | -276,600 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 102,197 | 97,013 | -5,184 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 61,100 | 96,300 | +35,200 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 76,408 | 94,593 | +18,185 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 55,700 | 87,420 | +31,720 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 37,107 | 82,953 | +45,846 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,254 | 79,122 | +63,868 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 187,307 | 78,391 | -108,916 | 1.27 | 0.67 | -0.60 | sell |
| JPMORGAN CHASE & CO | 67,536 | 76,820 | +9,284 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 47,862 | 75,061 | +27,199 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,211 | 68,650 | +45,439 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,197 | 66,706 | -7,491 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 19,279 | 65,451 | +46,172 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 104,621 | 58,755 | -45,866 | 0.01 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 0 | 56,052 | +56,052 | 0.00 | 0.22 | +0.22 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,491 | 54,328 | -2,163 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 54,003 | 54,199 | +196 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,289 | 54,196 | +50,907 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 77,681 | 50,028 | -27,653 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 42,391 | 49,001 | +6,610 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 45,000 | 45,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| MetLife Investment Management, LLC | 33,409 | 43,529 | +10,120 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,795 | 40,923 | +5,128 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 24,319 | 40,376 | +16,057 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 57,759 | 39,875 | -17,884 | 0.02 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 7,388 | 38,279 | +30,891 | 0.00 | 0.00 | +0.00 | buy |
| Round Rock Advisors, LLC | 37,229 | 37,229 | 0 | 0.09 | 0.12 | +0.02 | hold |
| Jump Financial, LLC | 184,522 | 34,900 | -149,622 | 0.04 | 0.01 | -0.04 | sell |
| BARCLAYS PLC | 11,353 | 34,467 | +23,114 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,751 | 34,281 | +9,530 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 47,500 | 34,083 | -13,417 | 0.30 | 0.26 | -0.04 | sell |
| Arax Advisory Partners | 323 | 31,955 | +31,632 | 0.00 | 0.01 | +0.00 | buy |