| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,764,471 | 5,660,132 | +2,895,661 | 0.65 | 1.07 | +0.42 | buy |
| Parkwood LLC | 323,000 | 708,000 | +385,000 | 0.28 | 0.32 | +0.05 | buy |
| Avoro Capital Advisors LLC | 4,345,000 | 4,645,548 | +300,548 | 0.43 | 0.34 | -0.09 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 287,000 | +287,000 | 0.00 | 0.07 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 46,370 | 330,467 | +284,097 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 229,536 | +229,536 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 159,874 | 356,112 | +196,238 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 144,811 | 262,990 | +118,179 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 96,345 | +96,345 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 51,725 | +51,725 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 37,574 | +37,574 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 32,586 | +32,586 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 59,399 | 91,514 | +32,115 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 27,394 | +27,394 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 26,188 | +26,188 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 24,100 | +24,100 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 76,850 | 100,406 | +23,556 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 12,847 | 35,346 | +22,499 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 21,073 | +21,073 | 0.00 | 0.03 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 16,385 | +16,385 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,162 | +15,162 | 0.00 | 0.01 | +0.01 | buy |
| TOWNSQUARE CAPITAL LLC | 0 | 11,391 | +11,391 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 7,595 | +7,595 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,756 | +6,756 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 5,398 | +5,398 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,382 | 37,635 | +5,253 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 116 | 3,706 | +3,590 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 1,853 | +1,853 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 11,122 | 11,988 | +866 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 61,791 | 62,239 | +448 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 995 | 1,425 | +430 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 409 | +409 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 355 | +355 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,290 | 1,572 | +282 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 4 | 200 | +196 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 17,236 | 17,341 | +105 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,838 | 2,875 | +37 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 652 | 682 | +30 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,047 | 2,056 | +9 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,184 | 4,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,049 | 3,049 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,140 | 35,140 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.36 | 0.25 | -0.11 | hold |
| Daiwa Securities Group Inc. | 203 | 203 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 3.01 | 2.75 | -0.26 | hold |
| Casdin Capital, LLC | 86,014 | 86,014 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Versant Venture Management, LLC | 5,652,922 | 5,652,922 | 0 | 45.22 | 43.56 | -1.66 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,563,798 | 1,563,798 | 0 | 0.40 | 0.29 | -0.11 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.59 | 0.43 | -0.16 | hold |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 3.63 | 2.37 | -1.26 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,489 | 9,489 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 3,597 | 3,597 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 26 | 0 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 37 | 0 | -37 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 120 | 50 | -70 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,701 | 24,619 | -82 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 117,412 | 117,307 | -105 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 24,094 | 23,959 | -135 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 1,109 | 841 | -268 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,533 | 20,233 | -300 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 24,855 | 24,356 | -499 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,165 | 11,613 | -552 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 27,510 | 26,949 | -561 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,324 | 713 | -611 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,027 | 12,323 | -704 | 0.01 | 0.01 | -0.00 | sell |
| TORONTO DOMINION BANK | 800 | 0 | -800 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 23,230 | 22,062 | -1,168 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,443 | 2,843 | -2,600 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 14,541 | 11,712 | -2,829 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 32,366 | 29,348 | -3,018 | 0.13 | 0.45 | +0.32 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,231 | 2,934 | -3,297 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 376,964 | 373,207 | -3,757 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 29,064 | 24,850 | -4,214 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 5,921 | 1,228 | -4,693 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 170,312 | 164,145 | -6,167 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 370,472 | 361,535 | -8,937 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,126 | 0 | -9,126 | 0.03 | 0.00 | -0.03 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 29,798 | 18,928 | -10,870 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 13,315 | 0 | -13,315 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 44,883 | 31,114 | -13,769 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 14,476 | 0 | -14,476 | 0.03 | 0.00 | -0.03 | sell |
| SG Americas Securities, LLC | 16,742 | 0 | -16,742 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 70,741 | 46,210 | -24,531 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 26,000 | 0 | -26,000 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 27,698 | 0 | -27,698 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 31,654 | 0 | -31,654 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,036,665 | 1,004,062 | -32,603 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 221,741 | 187,731 | -34,010 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 86,545 | 48,698 | -37,847 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 39,647 | 0 | -39,647 | 0.00 | 0.00 | -0.00 | sell |
| Long Corridor Asset Management Ltd | 40,000 | 0 | -40,000 | 0.21 | 0.00 | -0.21 | sell |