| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 6.15 | 7.19 | +1.04 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,118,904 | 6,720,188 | +1,601,284 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,181,161 | 5,637,684 | +1,456,523 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 4,622,151 | 4,622,151 | 0 | 2.40 | 2.18 | -0.22 | hold |
| BVF INC/IL | 3,835,886 | 4,460,886 | +625,000 | 2.02 | 2.34 | +0.31 | buy |
| BAKER BROS. ADVISORS LP | 4,345,736 | 4,345,736 | 0 | 0.40 | 0.41 | +0.01 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,360,000 | 4,226,809 | +866,809 | 1.31 | 1.89 | +0.57 | buy |
| Vestal Point Capital, LP | 775,000 | 3,603,465 | +2,828,465 | 0.45 | 1.66 | +1.21 | buy |
| STATE STREET CORP | 2,107,480 | 3,353,980 | +1,246,500 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 948,316 | 3,206,574 | +2,258,258 | 0.48 | 1.76 | +1.28 | buy |
| Versant Venture Management, LLC | 4,382,687 | 3,180,780 | -1,201,907 | 45.49 | 37.00 | -8.49 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,329,619 | 2,809,647 | +1,480,028 | 0.01 | 0.02 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,029,066 | 2,002,040 | +972,974 | 2.33 | 3.88 | +1.55 | buy |
| Aisling Capital Management LP | 1,472,331 | 1,555,664 | +83,333 | 4.82 | 5.37 | +0.55 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,204,844 | 1,540,812 | +335,968 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 398,890 | 1,433,152 | +1,034,262 | 0.01 | 0.03 | +0.02 | buy |
| Bellevue Group AG | 0 | 1,250,000 | +1,250,000 | 0.00 | 0.49 | +0.49 | buy |
| MPM BioImpact LLC | 1,173,376 | 1,176,928 | +3,552 | 2.11 | 1.50 | -0.61 | buy |
| DIMENSIONAL FUND ADVISORS LP | 568,367 | 1,041,372 | +473,005 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,300,096 | 1,024,304 | -275,792 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 295,878 | 1,001,527 | +705,649 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.42 | +0.42 | buy |
| NORTHERN TRUST CORP | 697,034 | 826,624 | +129,590 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 685,926 | +685,926 | 0.00 | 0.01 | +0.01 | buy |
| Alphabet Inc. | 744,948 | 684,275 | -60,673 | 0.45 | 0.28 | -0.17 | sell |
| MORGAN STANLEY | 805,530 | 684,063 | -121,467 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 785,057 | 658,483 | -126,574 | 0.01 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 57,991 | 651,993 | +594,002 | 0.05 | 0.67 | +0.62 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 307,651 | 647,739 | +340,088 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 448,714 | 546,689 | +97,975 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 523,377 | 528,698 | +5,321 | 0.17 | 0.17 | +0.00 | buy |
| Parkwood LLC | 708,000 | 505,000 | -203,000 | 0.94 | 0.74 | -0.21 | sell |
| Cormorant Asset Management, LP | 0 | 400,000 | +400,000 | 0.00 | 0.33 | +0.33 | buy |
| Allspring Global Investments Holdings, LLC | 26,955 | 392,227 | +365,272 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 223,571 | 387,542 | +163,971 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 379,100 | +379,100 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 314,862 | +314,862 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 278,077 | 305,398 | +27,321 | 0.03 | 0.03 | -0.00 | buy |
| Nextech Invest, Ltd. | 279,237 | 304,237 | +25,000 | 0.42 | 0.35 | -0.07 | buy |
| TD ASSET MANAGEMENT INC | 213,464 | 286,978 | +73,514 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 256,731 | +256,731 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 46,263 | 254,518 | +208,255 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 250,000 | +250,000 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 215,752 | 215,752 | 0 | 0.25 | 0.21 | -0.04 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,674 | 209,801 | +75,127 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 173,304 | 204,687 | +31,383 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 85,231 | 199,722 | +114,491 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 137,261 | 194,476 | +57,215 | 0.17 | 0.23 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 103,972 | 191,382 | +87,410 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 62,281 | 187,307 | +125,026 | 0.58 | 1.27 | +0.69 | buy |
| Casdin Capital, LLC | 86,014 | 186,014 | +100,000 | 0.08 | 0.23 | +0.15 | buy |
| Jump Financial, LLC | 0 | 184,522 | +184,522 | 0.00 | 0.04 | +0.04 | buy |
| Exome Asset Management LLC | 0 | 179,484 | +179,484 | 0.00 | 1.74 | +1.74 | buy |
| J. Goldman & Co LP | 32,291 | 171,771 | +139,480 | 0.02 | 0.13 | +0.11 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 154,658 | +154,658 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 123,000 | 152,620 | +29,620 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 70,037 | 130,246 | +60,209 | 0.12 | 0.25 | +0.13 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 148,057 | 128,792 | -19,265 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 285,859 | 120,872 | -164,987 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 67,438 | 104,621 | +37,183 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 362,213 | 102,197 | -260,016 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 26,382 | 82,339 | +55,957 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 247,855 | 78,513 | -169,342 | 0.01 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 59,668 | 77,681 | +18,013 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 61,859 | 76,408 | +14,549 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 74,496 | +74,496 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,628 | 74,197 | +54,569 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,120 | 67,536 | +43,416 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 85,488 | 66,327 | -19,161 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 63,000 | +63,000 | 0.00 | 0.22 | +0.22 | buy |
| IEQ CAPITAL, LLC | 89,268 | 62,703 | -26,565 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 0 | 61,100 | +61,100 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 31,125 | 57,759 | +26,634 | 0.01 | 0.02 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 49,630 | 56,491 | +6,861 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 56,280 | +56,280 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,480 | 55,700 | -7,780 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 33,580 | 54,003 | +20,423 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 149,712 | 49,179 | -100,533 | 0.02 | 0.01 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 33,108 | 47,862 | +14,754 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 22,211 | 47,500 | +25,289 | 0.17 | 0.30 | +0.14 | buy |
| PROFUND ADVISORS LLC | 25,219 | 46,684 | +21,465 | 0.01 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,694 | 45,063 | +39,369 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.05 | +0.05 | buy |
| Aquatic Capital Management LLC | 30,940 | 44,875 | +13,935 | 0.01 | 0.02 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 43,473 | +43,473 | 0.00 | 0.05 | +0.05 | buy |
| STRS OHIO | 36,100 | 42,700 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 42,391 | +42,391 | 0.00 | 0.00 | +0.00 | buy |
| Round Rock Advisors, LLC | 0 | 37,229 | +37,229 | 0.00 | 0.09 | +0.09 | buy |
| Squarepoint Ops LLC | 10,029 | 37,107 | +27,078 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 122,164 | 35,997 | -86,167 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,552 | 35,795 | +10,243 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 26,187 | 33,409 | +7,222 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 31,977 | +31,977 | 0.00 | 0.01 | +0.01 | buy |
| ADVISORY RESEARCH INC | 63,220 | 31,236 | -31,984 | 0.12 | 0.06 | -0.06 | sell |
| CWM, LLC | 29,444 | 29,687 | +243 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 27,956 | +27,956 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 27,506 | +27,506 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 27,100 | +27,100 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,289 | 27,077 | +4,788 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 67,500 | 27,016 | -40,484 | 0.91 | 0.48 | -0.43 | sell |