| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 2,659,000 | +2,659,000 | 0.00 | 0.41 | +0.41 | buy |
| VANGUARD GROUP INC | 1,635,829 | 2,547,075 | +911,246 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 890,000 | +890,000 | 0.00 | 0.25 | +0.25 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,096,787 | 5,977,587 | +880,800 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 375,000 | +375,000 | 0.00 | 0.23 | +0.23 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 122,100 | 254,714 | +132,614 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 735,533 | 847,442 | +111,909 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 72,675 | 153,758 | +81,083 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 15,764 | 92,349 | +76,585 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,582 | 311,800 | +61,218 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 15,893 | 64,339 | +48,446 | 0.10 | 0.11 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 120,647 | 166,671 | +46,024 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 55,548 | 98,557 | +43,009 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 265,278 | 307,319 | +42,041 | 0.02 | 0.01 | -0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,346 | +25,346 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 23,422 | +23,422 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 22,665 | +22,665 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 615,251 | 636,084 | +20,833 | 0.00 | 0.00 | -0.00 | buy |
| Castleview Partners, LLC | 0 | 18,950 | +18,950 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 16,566 | +16,566 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 94,019 | 109,864 | +15,845 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 980,239 | 995,943 | +15,704 | 0.01 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 15,600 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,848 | 49,410 | +15,562 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 522 | 13,452 | +12,930 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 10,050 | +10,050 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 23,570 | 32,780 | +9,210 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 62,109 | 68,503 | +6,394 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 290,454 | 294,196 | +3,742 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 5,898 | 9,538 | +3,640 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,219 | 16,308 | +3,089 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 13 | 2,719 | +2,706 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 2,631 | +2,631 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 46,553 | 47,925 | +1,372 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,558 | 11,153 | +595 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 193,168 | 193,696 | +528 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,810 | 14,950 | +140 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,137 | 12,174 | +37 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 2 | 21 | +19 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,241 | 2,241 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.43 | 0.23 | -0.20 | hold |
| Sarasin & Partners LLP | 65,081 | 65,081 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 3.37 | 2.16 | -1.20 | hold |
| Avoro Capital Advisors LLC | 4,535,000 | 4,535,000 | 0 | 0.37 | 0.23 | -0.15 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.41 | 0.28 | -0.13 | hold |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 3.51 | 2.38 | -1.13 | hold |
| Long Corridor Asset Management Ltd | 40,000 | 40,000 | 0 | 0.25 | 0.14 | -0.11 | hold |
| GAMMA Investing LLC | 52 | 52 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 15,803 | 15,803 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 841 | 841 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 995 | 995 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 103,087 | 102,709 | -378 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 42,393 | 41,917 | -476 | 0.05 | 0.03 | -0.02 | sell |
| Jump Financial, LLC | 16,898 | 16,338 | -560 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,111 | 2,208 | -903 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,820 | 0 | -1,820 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 13,388 | 10,860 | -2,528 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 52,800 | 45,500 | -7,300 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 21,748 | 11,009 | -10,739 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 46,787 | 35,686 | -11,101 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 11,419 | 0 | -11,419 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 11,946 | 0 | -11,946 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 13,955 | 0 | -13,955 | 0.01 | 0.00 | -0.01 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,246 | 0 | -15,246 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 41,173 | 0 | -41,173 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 150,025 | 20,928 | -129,097 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 5,340,802 | 5,094,974 | -245,828 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 510,882 | 261,014 | -249,868 | 0.27 | 0.07 | -0.19 | sell |